Journal ArticleDOI
Switching from repression to activation: microRNAs can up-regulate translation.
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TLDR
It is proposed that translation regulation by microRNPs oscillates between repression and activation during the cell cycle, and two well-studied microRNAs—Let-7 and the synthetic microRNA miRcxcr4—likewise induce translation up-regulation of target mRNAs on cell cycle arrest.Abstract:
AU-rich elements (AREs) and microRNA target sites are conserved sequences in messenger RNA (mRNA) 3' untranslated regions (3'UTRs) that control gene expression posttranscriptionally. Upon cell cycle arrest, the ARE in tumor necrosis factor-alpha (TNFalpha) mRNA is transformed into a translation activation signal, recruiting Argonaute (AGO) and fragile X mental retardation-related protein 1 (FXR1), factors associated with micro-ribonucleoproteins (microRNPs). We show that human microRNA miR369-3 directs association of these proteins with the AREs to activate translation. Furthermore, we document that two well-studied microRNAs-Let-7 and the synthetic microRNA miRcxcr4-likewise induce translation up-regulation of target mRNAs on cell cycle arrest, yet they repress translation in proliferating cells. Thus, activation is a common function of microRNPs on cell cycle arrest. We propose that translation regulation by microRNPs oscillates between repression and activation during the cell cycle.read more
Citations
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Journal ArticleDOI
Antisense transcripts are targets for activating small RNAs
Jacob C. Schwartz,Scott T. Younger,Ngoc Bich Nguyen,Daniel B. Hardy,Brett P. Monia,David R. Corey,Bethany A. Janowski +6 more
TL;DR: It is found that antisense transcripts are the target for agRNAs that activate or repress expression of progesterone receptor (PR) by both activating and inhibitory ag RNAs.
Journal ArticleDOI
Integrative approaches for predicting microRNA function and prioritizing disease-related microRNA using biological interaction networks
TL;DR: The existing computational approaches for predicting potential disease-related miRNA based on networks are summarized and the confronted difficulties that help understand the research status are presented.
Journal ArticleDOI
Analysis of miR-195 and miR-497 expression, regulation and role in breast cancer
Dan Li,Yulan Zhao,Changxing Liu,Xiaona Chen,Yanting Qi,Yue Jiang,Chao Zou,Xiaolong Zhang,Shunying Liu,Xuejing Wang,Dan Zhao,Qiang Sun,Zhenbing Zeng,Andreas Dress,Marie C.M. Lin,Hsiang-Fu Kung,Hallgeir Rui,Ling-Zhi Liu,Feng Mao,Bing-Hua Jiang,Lihui Lai +20 more
TL;DR: The data imply that both miR-195 and miR,497 play important inhibitory roles in breast cancer malignancy and may be the potential therapeutic and diagnostic targets.
Journal ArticleDOI
Causes and consequences of microRNA dysregulation.
Marilena V. Iorio,Carlo M. Croce +1 more
TL;DR: The main mechanisms regulating microRNAs and the consequences of their aberrant expression in cancer are reviewed, with a glance at the possible implications at a clinical point of view.
Journal ArticleDOI
MicroRNA and drug resistance.
TL;DR: The molecular targets and mechanisms of chemosensitivity and chemoresistance are elucidated and several research groups have shown that the expressions of miRNAs in chemoresistant cancer cells and their parental chemosensitive ones are different.
References
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TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Control of translation and mRNA degradation by miRNAs and siRNAs
TL;DR: Possible mechanisms by which miRNAs control translation and mRNA degradation are discussed, an emerging theme is that mi RNAs, and siRNAs to some extent, target m RNAs to the general eukaryotic machinery for mRNA degradation and translation control.
Journal ArticleDOI
AU-rich elements: characterization and importance in mRNA degradation.
Chyi-Ying A. Chen,Ann-Bin Shyu +1 more
TL;DR: Observations suggest that Adenylate/uridylate-rich elements play a critical role in the regulation of gene expression during cell growth and differentiation and in the immune response.
Journal ArticleDOI
Specificity of microRNA target selection in translational repression
John G. Doench,Phillip A. Sharp +1 more
TL;DR: The ability of an miRNA to translationally repress a target mRNA is largely dictated by the free energy of binding of the first eight nucleotides in the 5' region of the miRNA, however, G:U wobble base-pairing in this region interferes with activity beyond that predicted on the basis of thermodynamic stability.
Journal ArticleDOI
From the U. S. A.
TL;DR: In this article, the existence of a monotone interpolating function with the same index set was shown to be necessary and sufficient for continuous interpolating functional if the index set I is finite, but not sufficient if I is infinite.
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