Journal ArticleDOI
Switching from repression to activation: microRNAs can up-regulate translation.
Reads0
Chats0
TLDR
It is proposed that translation regulation by microRNPs oscillates between repression and activation during the cell cycle, and two well-studied microRNAs—Let-7 and the synthetic microRNA miRcxcr4—likewise induce translation up-regulation of target mRNAs on cell cycle arrest.Abstract:
AU-rich elements (AREs) and microRNA target sites are conserved sequences in messenger RNA (mRNA) 3' untranslated regions (3'UTRs) that control gene expression posttranscriptionally. Upon cell cycle arrest, the ARE in tumor necrosis factor-alpha (TNFalpha) mRNA is transformed into a translation activation signal, recruiting Argonaute (AGO) and fragile X mental retardation-related protein 1 (FXR1), factors associated with micro-ribonucleoproteins (microRNPs). We show that human microRNA miR369-3 directs association of these proteins with the AREs to activate translation. Furthermore, we document that two well-studied microRNAs-Let-7 and the synthetic microRNA miRcxcr4-likewise induce translation up-regulation of target mRNAs on cell cycle arrest, yet they repress translation in proliferating cells. Thus, activation is a common function of microRNPs on cell cycle arrest. We propose that translation regulation by microRNPs oscillates between repression and activation during the cell cycle.read more
Citations
More filters
Journal ArticleDOI
MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation
Xiaorong Zhang,Xinxin Zuo,Bo Yang,Zongran Li,Yuanchao Xue,Yu Zhou,Jie Huang,Xiaolu Zhao,Jie Zhou,Yun Yan,Huiqiong Zhang,Peipei Guo,Hui Sun,Lin Guo,Yi Zhang,Xiang-Dong Fu,Xiang-Dong Fu +16 more
TL;DR: It is reported that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts.
Journal ArticleDOI
MicroRNA history: discovery, recent applications, and next frontiers.
TL;DR: This review focuses on the main progress in this field and discusses the most important findings under a historical perspective, and examines microRNAs as markers of disease diagnosis and prognosis, and as new therapeutic targets.
Journal ArticleDOI
Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells.
Nalinie S. Wickramasinghe,Tissa T. Manavalan,Susan M. Dougherty,Krista A. Riggs,Yong Li,Carolyn M. Klinge +5 more
TL;DR: These results are the first to demonstrate that E2 represses the expression of an oncogenic miRNA, miR-21, by activating estrogen receptor in MCF-7 cells.
Journal ArticleDOI
Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility.
Milena S. Nicoloso,Hao Sun,Hao Sun,Riccardo Spizzo,Hyunsoo Kim,Priyankara Wickramasinghe,Masayoshi Shimizu,Sylwia E. Wojcik,Jana Ferdin,Jana Ferdin,Tanja Kunej,Lianchun Xiao,Siranoush Manoukian,Giorgio Secreto,Fernando Ravagnani,Xuemei Wang,Paolo Radice,Carlo M. Croce,Ramana V. Davuluri,George A. Calin +19 more
TL;DR: It is proposed that transcribed target SNPs alter miRNA gene regulation and, consequently, protein expression, contributing to the likelihood of cancer susceptibility, by a novel mechanism of subtle gene regulation.
Journal ArticleDOI
MicroRNAs: novel regulators in cardiac development and disease
TL;DR: The development and use of miRNA antagonists (antagomirs) to target miRNAs in vivo are focused on, which may translate into novel therapeutic strategies for heart disease in the future.
References
More filters
疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Control of translation and mRNA degradation by miRNAs and siRNAs
TL;DR: Possible mechanisms by which miRNAs control translation and mRNA degradation are discussed, an emerging theme is that mi RNAs, and siRNAs to some extent, target m RNAs to the general eukaryotic machinery for mRNA degradation and translation control.
Journal ArticleDOI
AU-rich elements: characterization and importance in mRNA degradation.
Chyi-Ying A. Chen,Ann-Bin Shyu +1 more
TL;DR: Observations suggest that Adenylate/uridylate-rich elements play a critical role in the regulation of gene expression during cell growth and differentiation and in the immune response.
Journal ArticleDOI
Specificity of microRNA target selection in translational repression
John G. Doench,Phillip A. Sharp +1 more
TL;DR: The ability of an miRNA to translationally repress a target mRNA is largely dictated by the free energy of binding of the first eight nucleotides in the 5' region of the miRNA, however, G:U wobble base-pairing in this region interferes with activity beyond that predicted on the basis of thermodynamic stability.
Journal ArticleDOI
From the U. S. A.
TL;DR: In this article, the existence of a monotone interpolating function with the same index set was shown to be necessary and sufficient for continuous interpolating functional if the index set I is finite, but not sufficient if I is infinite.
Related Papers (5)
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more