Journal ArticleDOI
Switching from repression to activation: microRNAs can up-regulate translation.
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TLDR
It is proposed that translation regulation by microRNPs oscillates between repression and activation during the cell cycle, and two well-studied microRNAs—Let-7 and the synthetic microRNA miRcxcr4—likewise induce translation up-regulation of target mRNAs on cell cycle arrest.Abstract:
AU-rich elements (AREs) and microRNA target sites are conserved sequences in messenger RNA (mRNA) 3' untranslated regions (3'UTRs) that control gene expression posttranscriptionally. Upon cell cycle arrest, the ARE in tumor necrosis factor-alpha (TNFalpha) mRNA is transformed into a translation activation signal, recruiting Argonaute (AGO) and fragile X mental retardation-related protein 1 (FXR1), factors associated with micro-ribonucleoproteins (microRNPs). We show that human microRNA miR369-3 directs association of these proteins with the AREs to activate translation. Furthermore, we document that two well-studied microRNAs-Let-7 and the synthetic microRNA miRcxcr4-likewise induce translation up-regulation of target mRNAs on cell cycle arrest, yet they repress translation in proliferating cells. Thus, activation is a common function of microRNPs on cell cycle arrest. We propose that translation regulation by microRNPs oscillates between repression and activation during the cell cycle.read more
Citations
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Journal ArticleDOI
Overexpression of miRNA-21 promotes radiation-resistance of non-small cell lung cancer
TL;DR: Investigation of the potential role of miRNA-21 in non-small cell lung cancer found it to be positively associated with lymph node metastasis, clinical stage and poor prognosis, and Multivariate Cox regression analysis showed that mi RNA-21 was an independent prognostic factor for patients.
Journal ArticleDOI
MetastamiRs: non-coding MicroRNAs driving cancer invasion and metastasis.
César López-Camarillo,Laurence A. Marchat,Elena Aréchaga-Ocampo,Carlos Pérez-Plasencia,Oscar Del Moral-Hernández,Elizabeth J. Castaneda-Ortiz,Sergio Rodríguez-Cuevas +6 more
TL;DR: A review of the current knowledge of miRNAs in cancer with a special focus on metastamiRs and their potential use as novel specific markers for cancer progression is presented.
Journal ArticleDOI
Smoke-induced microRNA and related proteome alterations. Modulation by chemopreventive agents
Silvio De Flora,Roumen Balansky,Francesco D'Agostini,Cristina Cartiglia,Mariagrazia Longobardi,Vernon E. Steele,Alberto Izzotti +6 more
TL;DR: Exposure to cigarette smoke results in an intense dysregulation of miRNA expression in the respiratory tract, which is mainly oriented in the sense of downregulation, and a variety of cancer chemopreventive agents tested in the laboratory modulated both baseline and CS‐related miRNA and proteome alterations, thus contributing to evaluate both safety and efficacy of dietary and pharmacological agents.
Journal ArticleDOI
MicroRNA-17-92a upregulation by estrogen leads to Bim targeting and inhibition of osteoblast apoptosis.
Lei Guo,Jiping Xu,Jin Qi,Lianfang Zhang,Jinsheng Wang,Jing Liang,Niandong Qian,Hanbing Zhou,Li Wei,Lianfu Deng +9 more
TL;DR: Results showed that miR-17-92a, plays a significant role in the process of estrogen protection of osteoblasts against apoptosis, by regulating Bim expression.
Journal ArticleDOI
Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes.
Jette Bork-Jensen,Camilla Scheele,Daniel V. Christophersen,Daniel V. Christophersen,Emma Nilsson,Martin Friedrichsen,Martin Friedrichsen,Martin Friedrichsen,Denise S. Fernandez-Twinn,Louise G. Grunnet,Thomas Litman,Kim Holmstrøm,Birgitte F. Vind,Kurt Højlund,Henning Beck-Nielsen,Jørgen F. P. Wojtaszewski,Susan E. Ozanne,Bente Klarlund Pedersen,Pernille Poulsen,Pernille Poulsen,Allan Vaag,Allan Vaag +21 more
TL;DR: Type 2 diabetes is associated with non-genetic downregulation of several miRNAs in skeletal muscle including miR-15b and miR -16, potentially targeting insulin signalling.
References
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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Control of translation and mRNA degradation by miRNAs and siRNAs
TL;DR: Possible mechanisms by which miRNAs control translation and mRNA degradation are discussed, an emerging theme is that mi RNAs, and siRNAs to some extent, target m RNAs to the general eukaryotic machinery for mRNA degradation and translation control.
Journal ArticleDOI
AU-rich elements: characterization and importance in mRNA degradation.
Chyi-Ying A. Chen,Ann-Bin Shyu +1 more
TL;DR: Observations suggest that Adenylate/uridylate-rich elements play a critical role in the regulation of gene expression during cell growth and differentiation and in the immune response.
Journal ArticleDOI
Specificity of microRNA target selection in translational repression
John G. Doench,Phillip A. Sharp +1 more
TL;DR: The ability of an miRNA to translationally repress a target mRNA is largely dictated by the free energy of binding of the first eight nucleotides in the 5' region of the miRNA, however, G:U wobble base-pairing in this region interferes with activity beyond that predicted on the basis of thermodynamic stability.
Journal ArticleDOI
From the U. S. A.
TL;DR: In this article, the existence of a monotone interpolating function with the same index set was shown to be necessary and sufficient for continuous interpolating functional if the index set I is finite, but not sufficient if I is infinite.
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