Synergistic and antibiofilm activity of the antimicrobial peptide P5 against carbapenem-resistant Pseudomonas aeruginosa.
Melina María Belén Martínez,Sónia Gonçalves,Mário R. Felício,Patricia del Valle Maturana,Nuno C. Santos,Liliana Semorile,Axel Hollmann,Paulo Cesar Maffia,Paulo Cesar Maffia +8 more
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TLDR
The feasibility of using P5 against a carbapenem-resistant clinical isolate of Pseudomonas aeruginosa, one of the most common and risky pathogens in clinical practice, is analyzed, confirming the promising application of P5 in multi-resistant infections therapeutics.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2019-07-01 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Antimicrobial peptides & Antimicrobial.read more
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Fundamentals on the molecular mechanism of action of antimicrobial peptides
Jessica Audrey Feijó Corrêa,Alberto Gonçalves Evangelista,Tiago de Melo Nazareth,Tiago de Melo Nazareth,Fernando Bittencourt Luciano +4 more
TL;DR: The main mechanisms of peptides are related to changes in the physiological function of membranes, but there are also alterations in cytoplasmic components, which contribute to the process of choosing the best peptide to obtain an expected action against a given microorganism.
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Zeta potential beyond materials science: Applications to bacterial systems and to the development of novel antimicrobials.
Anike Paula Virginia Ferreyra Maillard,Juan Carlos Espeche,Patricia del Valle Maturana,Andrea Carmen Cutró,Axel Hollmann,Axel Hollmann +5 more
TL;DR: The theory of zeta potential (ZP) and the most relevant data about how it has been used for studying bacteria have been summarized in this paper and the feasibility of using the ZP technique to assess antimicrobial-induced changes in the bacterial surface.
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Synergistic antibacterial activity and mechanism of action of nisin/carvacrol combination against Staphylococcus aureus and their application in the infecting pasteurized milk.
TL;DR: In this paper , the synergistic interactions of nisin and carvacrol were detected and the MIC of Nisin and CARVACCL against S. aureus were 60 and 125 μg/mL, respectively.
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Activity of Antimicrobial Peptides and Ciprofloxacin against Pseudomonas aeruginosa Biofilms.
TL;DR: AMPs do not easily induce resistance in P. aeruginosa and can be used in combination with ciprofloxacin to treat biofilm and depolarized the cell membranes of biofilm cells at 1× MIC.
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Boosting Synergistic Effects of Short Antimicrobial Peptides With Conventional Antibiotics Against Resistant Bacteria.
TL;DR: In this paper, a checkerboard method was used to evaluate synergistic effects of the parent peptide and the Nal-tagged peptides, and the synergistic mechanism of action between the peptides and vancomycin was analyzed.
References
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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TL;DR: In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.
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Antibiotic resistance—the need for global solutions
Ramanan Laxminarayan,Ramanan Laxminarayan,Ramanan Laxminarayan,Adriano Duse,Chand Wattal,Anita K. M. Zaidi,Heiman F. L. Wertheim,Nithima Sumpradit,Erika Vlieghe,Gabriel Levy Hara,Ian M. Gould,Herman Goossens,Christina Greko,Anthony D. So,Maryam Bigdeli,Goeran Tomson,Will Woodhouse,Eva Ombaka,Arturo Quizhpe Peralta,Farah Naz Qamar,Fatima Mir,Sam Kariuki,Zulfigar A. Bhutta,Anthony R.M. Coates,Richard Bergstrom,Gerard D. Wright,Eric D. Brown,Otto Cars +27 more
TL;DR: The global situation of antibiotic resistance, its major causes and consequences, and key areas in which action is urgently needed are described and identified.
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Antibiotic resistance of bacterial biofilms
TL;DR: Biofilms can be prevented by early aggressive antibiotic prophylaxis or therapy and they can be treated by chronic suppressive therapy and a promising strategy may be the use of enzymes that can dissolve the biofilm matrix as well as quorum-sensing inhibitors that increase biofilm susceptibility to antibiotics.
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Synergy, antagonism, and what the chequerboard puts between them
TL;DR: This document is intended to be used for educational purposes only and should not be relied on as a guide for making decisions about major decisions about copyrighted material.