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The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM

Stephen B. Edge, +2 more
- 24 Feb 2010 - 
- Vol. 17, Iss: 6, pp 1471-1474
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TLDR
A marked increase in the use of international datasets for more highly evidenced-based changes in staging, and the enhanced use of nonanatomic prognostic factors in defining the stage grouping are notable.
Abstract: 
The American Joint Committee on Cancer and the International Union for Cancer Control update the tumor-node-metastasis (TNM) cancer staging system periodically. The most recent revision is the 7th edition, effective for cancers diagnosed on or after January 1, 2010. This editorial summarizes the background of the current revision and outlines the major issues revised. Most notable are the marked increase in the use of international datasets for more highly evidenced-based changes in staging, and the enhanced use of nonanatomic prognostic factors in defining the stage grouping. The future of cancer staging lies in the use of enhanced registry data standards to support personalization of cancer care through cancer outcome prediction models and nomograms.

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Journal ArticleDOI

Perineural Spread in Noncutaneous Head and Neck Cancer: New Insights into an Old Problem.

Moran Amit, +6 more
- 26 Feb 2016 - 
TL;DR: While clinical symptoms and physical examination may suggest the presence of neural invasion, specific imaging modalities such as fat-suppressed T1-weighted magnetic resonance images, should be utilized to identify perineural tumor spread in its early phases.
Journal ArticleDOI

Elevated platelet count is a strong predictor of poor prognosis in stage I non-small cell lung cancer patients.

Yongling Ji, +4 more
- 11 Feb 2015 - 
TL;DR: It is demonstrated that preoperative platelet count is a useful predictor of high risk progression and poor prognosis in stage I NSCLC patients.
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Is Robot-assisted Surgery Contraindicated in the Case of Partial Nephrectomy for Complex Tumours or Relevant Comorbidities? A Comparative Analysis of Morbidity, Renal Function, and Oncologic Outcomes

Alessandro Larcher, +11 more
- 01 May 2018 - 
TL;DR: RAPN is associated with overall better perioperative morbidity and lower rates of complications, regardless of characteristics such as tumour complexity and patient comorbidity status, and functional and oncologic outcomes are equal after RARP and OPN.
Journal ArticleDOI

Adjuvant pelvic radiation is associated with improved survival and decreased disease recurrence in pelvic node-positive penile cancer after lymph node dissection: A multi-institutional study.

Dominic H. Tang, +12 more
- 01 Oct 2017 - 
TL;DR: Adjuvant pelvic radiation is associated with improved survival and decreased recurrence in this population of patients with penile cancer with positive pelvic lymph nodes after lymph node dissection.
Journal ArticleDOI

Tumor suppressive microRNA-124a inhibits stemness and enhances gefitinib sensitivity of non-small cell lung cancer cells by targeting ubiquitin-specific protease 14

Fei Yu, +21 more
- 28 Jul 2018 - 
TL;DR: It is found that hsa-miR-124a was downregulated during spheroid formation of the NSCLC cell lines SPC-A1 and NCI-H1650 andNSCLC tissues compared with normal lung cells and tissues, and ubiquitin-specific protease 14 (USP14) was confirmed to be a direct target of hsa.R- 124a.
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