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The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM

Stephen B. Edge, +2 more
- 24 Feb 2010 - 
- Vol. 17, Iss: 6, pp 1471-1474
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TLDR
A marked increase in the use of international datasets for more highly evidenced-based changes in staging, and the enhanced use of nonanatomic prognostic factors in defining the stage grouping are notable.
Abstract: 
The American Joint Committee on Cancer and the International Union for Cancer Control update the tumor-node-metastasis (TNM) cancer staging system periodically. The most recent revision is the 7th edition, effective for cancers diagnosed on or after January 1, 2010. This editorial summarizes the background of the current revision and outlines the major issues revised. Most notable are the marked increase in the use of international datasets for more highly evidenced-based changes in staging, and the enhanced use of nonanatomic prognostic factors in defining the stage grouping. The future of cancer staging lies in the use of enhanced registry data standards to support personalization of cancer care through cancer outcome prediction models and nomograms.

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High blood sugar levels significantly impact the prognosis of colorectal cancer patients through down-regulation of microRNA-16 by targeting Myb and VEGFR2

I-Ping Yang, +7 more
- 25 Feb 2016 - 
TL;DR: Hyperglycemia can impact the clinical outcomes of CRC patients, likely by inhibiting miR-16 expression and the expression of its downstream genes Myb and VEGFR2.
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Is trans-anal total mesorectal excision really safe and better than laparoscopic total mesorectal excision with a perineal approach first in patients with low rectal cancer? A learning curve with case-matched study in 68 patients.

D. Mege, +5 more
- 14 May 2018 - 
TL;DR: To compare the learning curve for trans‐anal total mesorectal excision (TATME) with laparoscopic TME started by a perineal approach (LTME) is compared.
Journal ArticleDOI

Disrupting VEGF-A paracrine and autocrine loops by targeting SHP-1 suppresses triple negative breast cancer metastasis.

Jung Chen Su, +16 more
- 01 Jul 2016 - 
TL;DR: It is implied that SHP-1/p-STAT3/VEGF-A axis is a potential therapeutic target for metastatic TNBC, and the more potent SC-78 may be a promising lead for suppressing metastasis of TNBC.
Journal ArticleDOI

Dynamics of EGFR Mutation Load in Plasma for Prediction of Treatment Response and Disease Progression in Patients With EGFR-Mutant Lung Adenocarcinoma.

Álvaro Taus, +13 more
- 01 Sep 2018 - 
TL;DR: The liquid biopsy for ctDNA‐based assessment of EGFR mutations is a reliable technique for diagnosis and follow‐up in patients with EGFR‐mutant lung adenocarcinoma in routine clinical practice.
Journal ArticleDOI

Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer.

Anne-Catherine Lhoumeau, +16 more
- 11 May 2015 - 
TL;DR: PTK7 expression represents a potential prognostic biomarker and a novel therapeutic target in colorectal cancer and was significantly associated with a reduced metastasis-free survival in non-metastatic patients.
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