The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM
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TLDR
A marked increase in the use of international datasets for more highly evidenced-based changes in staging, and the enhanced use of nonanatomic prognostic factors in defining the stage grouping are notable.Abstract:
The American Joint Committee on Cancer and the International Union for Cancer Control update the tumor-node-metastasis (TNM) cancer staging system periodically. The most recent revision is the 7th edition, effective for cancers diagnosed on or after January 1, 2010. This editorial summarizes the background of the current revision and outlines the major issues revised. Most notable are the marked increase in the use of international datasets for more highly evidenced-based changes in staging, and the enhanced use of nonanatomic prognostic factors in defining the stage grouping. The future of cancer staging lies in the use of enhanced registry data standards to support personalization of cancer care through cancer outcome prediction models and nomograms.read more
Citations
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Journal ArticleDOI
Postoperative Nomogram for Predicting Cancer-Specific Mortality in Medullary Thyroid Cancer.
Allen S. Ho,Lu Wang,Frank L. Palmer,Changhong Yu,Arnbjorn Toset,Snehal G. Patel,Michael W. Kattan,R. Michael Tuttle,Ian Ganly +8 more
TL;DR: The first nomogram that estimates cause-specific mortality in individual patients with MTC is described, which will facilitate patient counseling in terms of prognosis and subsequent clinical follow up.
Journal ArticleDOI
Identification of high-risk cutaneous melanoma tumors is improved when combining the online American Joint Committee on Cancer Individualized Melanoma Patient Outcome Prediction Tool with a 31-gene expression profile-based classification.
Laura K. Ferris,Aaron S. Farberg,Brooke Middlebrook,Clare Johnson,Natalie Lassen,Kristen M. Oelschlager,Derek Maetzold,Robert W. Cook,Darrell S. Rigel,Pedram Gerami +9 more
TL;DR: The GEP provides valuable prognostic information and improves identification of high‐risk melanomas when used together with the AJCC online prediction tool.
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Elevated CEA and CA19-9 serum levels independently predict advanced pancreatic cancer at diagnosis
Labrinus van Manen,Jesse V. Groen,Hein Putter,Alexander L. Vahrmeijer,Rutger-Jan Swijnenburg,Bert A. Bonsing,J. Sven D. Mieog +6 more
TL;DR: Implementing CEA and CA19-9 serum levels during MDT meetings as an additional tool for establishing tumour resectability is worthwhile for tailored diagnostics.
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Prognostic impact of the tumor immune microenvironment in synovial sarcoma.
Naoki Oike,Hiroyuki Kawashima,Akira Ogose,Tetsuo Hotta,Hiroshi Hatano,Takashi Ariizumi,Taro Sasaki,Tetsuro Yamagishi,Hajime Umezu,Naoto Endo +9 more
TL;DR: This represents the first report investigating the tumor immune microenvironment as a prognostic factor in synovial sarcoma, indicating that CD163+ macrophages are associated with tumor progression.
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miR-204 regulates the EMT by targeting snai1 to suppress the invasion and migration of gastric cancer.
TL;DR: Evidence is provided that miR-204 may suppress the metastasis and invasion of GC cells through the regulation of the EMT process by targeting snai1.
References
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Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
Related Papers (5)
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more