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The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM

Stephen B. Edge, +2 more
- 24 Feb 2010 - 
- Vol. 17, Iss: 6, pp 1471-1474
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TLDR
A marked increase in the use of international datasets for more highly evidenced-based changes in staging, and the enhanced use of nonanatomic prognostic factors in defining the stage grouping are notable.
Abstract: 
The American Joint Committee on Cancer and the International Union for Cancer Control update the tumor-node-metastasis (TNM) cancer staging system periodically. The most recent revision is the 7th edition, effective for cancers diagnosed on or after January 1, 2010. This editorial summarizes the background of the current revision and outlines the major issues revised. Most notable are the marked increase in the use of international datasets for more highly evidenced-based changes in staging, and the enhanced use of nonanatomic prognostic factors in defining the stage grouping. The future of cancer staging lies in the use of enhanced registry data standards to support personalization of cancer care through cancer outcome prediction models and nomograms.

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Journal ArticleDOI

Radiomic Features Are Associated With EGFR Mutation Status in Lung Adenocarcinomas.

Ying Liu, +7 more
- 01 Sep 2016 - 
TL;DR: Computed tomography-based radiomic features of peripheral lung adenocarcinomas can capture useful information regarding tumor phenotype, and the model built can be useful to predict the presence of EGFR mutations in peripheral lung carcinomas in Asian patients when mutational profiling is not available or possible.
Journal ArticleDOI

Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set.

Eric A. Klein, +14 more
- 01 Sep 2021 - 
TL;DR: In this article, a multi-cancer early detection (MCED) test was proposed to detect cancer signals across multiple cancer types and predict cancer signal origin (CSO) with high accuracy.
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HOTAIR long non-coding RNA is a negative prognostic factor not only in primary tumors, but also in the blood of colorectal cancer patients.

Miroslav Svoboda, +14 more
- 01 Jul 2014 - 
TL;DR: Analysis of HOTAIR expression levels in tumor and blood of incident sporadic CRC patients in relation to their overall survival and mortality suggests that HOTA IR blood levels may serve as potential surrogate prognostic marker in sporadic CRC.
Journal ArticleDOI

From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world

Dimitrios Dimitroulis, +14 more
- 07 Aug 2017 - 
TL;DR: The current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma is described, which remains a challenge to early diagnose, and treat effectively.
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Prognostic and Prediction Tools in Bladder Cancer: A Comprehensive Review of the Literature.

Luis A. Kluth, +9 more
- 01 Aug 2015 - 
TL;DR: A large number of prediction models that hold the promise of facilitating treatment decisions for patients with bladder cancer (BCa) are found, however, many models are missing confirmation in a different patient cohort, and only a few studies have tested the clinical utility of any given model as measured by its ability to improve clinical decision making.
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