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The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM

Stephen B. Edge, +2 more
- 24 Feb 2010 - 
- Vol. 17, Iss: 6, pp 1471-1474
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TLDR
A marked increase in the use of international datasets for more highly evidenced-based changes in staging, and the enhanced use of nonanatomic prognostic factors in defining the stage grouping are notable.
Abstract: 
The American Joint Committee on Cancer and the International Union for Cancer Control update the tumor-node-metastasis (TNM) cancer staging system periodically. The most recent revision is the 7th edition, effective for cancers diagnosed on or after January 1, 2010. This editorial summarizes the background of the current revision and outlines the major issues revised. Most notable are the marked increase in the use of international datasets for more highly evidenced-based changes in staging, and the enhanced use of nonanatomic prognostic factors in defining the stage grouping. The future of cancer staging lies in the use of enhanced registry data standards to support personalization of cancer care through cancer outcome prediction models and nomograms.

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Journal ArticleDOI

A nomogram to predict pathologic complete response (pCR) and the value of tumor-infiltrating lymphocytes (TILs) for prediction of response to neoadjuvant chemotherapy (NAC) in breast cancer patients

Hye Won Hwang, +13 more
- 01 Jan 2019 - 
TL;DR: High pre-NAC TIL levels were significantly predictive of pCR in BC, and can act as a surrogate marker for predicting therapeutic effects of a TCHP regimen for HER2-positive BC.
Journal ArticleDOI

Keratin 17 in premalignant and malignant squamous lesions of the cervix: proteomic discovery and immunohistochemical validation as a diagnostic and prognostic biomarker

Luisa F. Escobar-Hoyos, +8 more
- 01 Apr 2014 - 
TL;DR: Both KRT4 and K RT17 expressions are related to the histopathology of the cervical squamous mucosa; KRT17 is highly overexpressed in immature squamous metaplasia, in HSIL, and in squamous cell carcinoma and the level of KRT 17 in squ Famouscell carcinoma may help to identify patients who are at greatest risk for cervical cancer mortality.
Journal ArticleDOI

Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia.

Susanne K. Pedersen, +14 more
- 06 Oct 2015 - 
TL;DR: The sensitivity for cancer of this two-marker blood test justifies prospective evaluation in a true screening population relative to a proven screening test.
Journal ArticleDOI

Meta‐analysis of the influence of surgical margin and adjuvant radiotherapy on local recurrence after resection of sporadic desmoid‐type fibromatosis

Matthijs L. Janssen, +9 more
- 01 Mar 2017 - 
TL;DR: The objective of this study was to estimate the effect of surgical resection margins and adjuvant radiotherapy on rates of recurrence of DF.
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Cholangiocarcinoma: classification, diagnosis, staging, imaging features, and management

Irai S. Oliveira, +5 more
- 07 Mar 2017 - 
TL;DR: The role imaging plays in the diagnosis, classification, staging, and post-treatment assessment of cholangiocarcinoma is focused on.
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