Journal ArticleDOI
The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats
TLDR
Mrp1 might play important roles in lead detoxification by Nrf2 in rats' testes, and significant increases were observed in the expressions of Mrp1 and NRF2 in two lead groups.About:
This article is published in Environmental Toxicology and Pharmacology.The article was published on 2013-01-01. It has received 19 citations till now. The article focuses on the topics: Lead acetate.read more
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Protective effect of curcumin against heavy metals-induced liver damage.
TL;DR: Curcumin reduces the hepatotoxicity induced by arsenic, cadmium, chromium, copper, lead and mercury, prevents histological injury, lipid peroxidation and glutathione (GSH) depletion, maintains the liver antioxidant enzyme status and protects against mitochondrial dysfunction.
Journal ArticleDOI
Indigofera oblongifolia Prevents Lead Acetate-Induced Hepatotoxicity, Oxidative Stress, Fibrosis and Apoptosis in Rats
TL;DR: The findings of the current study revealed that I. oblongifolia had protective, anti-fibrotic, antioxidant, and anti-apoptotic activities on PbAc-induced hepatotoxicity in adult male Wistar rats.
Journal ArticleDOI
Proanthocyanidins Attenuation of Chronic Lead-Induced Liver Oxidative Damage in Kunming Mice via the Nrf2/ARE Pathway
TL;DR: PCs were demonstrated to have protective, antioxidant, andAnti-ER stress and anti-apoptotic activities in liver damage caused by chronic lead exposure in the Kunming mouse, resulting in decreasing ER stress and apoptosis of liver tissue.
Journal ArticleDOI
Lead (Pb) exposure induces dopaminergic neurotoxicity in Caenorhabditis elegans: Involvement of the dopamine transporter
Ayodele J. Akinyemi,Mahfuzur R. Miah,Omamuyovwi M. Ijomone,Omamuyovwi M. Ijomone,Aristidis Tsatsakis,Félix Alexandre Antunes Soares,Félix Alexandre Antunes Soares,Alexey A. Tinkov,Anatoly V. Skalny,Anatoly V. Skalny,Vivek Venkataramani,Michael Aschner +11 more
TL;DR: It is concluded that PKC activation is directly involved in the neurotoxicity of Pb, and induced dopaminergic dysfunction in C. elegans by altering dat-1 gene levels, but pkc mutants showed significant resistance to Pb2+ toxicity.
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The role of Nrf2 in protection against Pb-induced oxidative stress and apoptosis in SH-SY5Y cells
TL;DR: The results indicated that the Nrf2-ARE system exhibited a protective role in Pb-induced neurotoxicity, providing potential therapeutic strategies for the prevention and treatment of P b-related diseases.
References
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Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Oxidative stress and male infertility—a clinical perspective
TL;DR: This review will provide an overview of oxidative biochemistry related to sperm health and identify which men are most at risk of oxidative infertility, and outline methods available for diagnosing oxidative stress and the various treatments available.
Journal Article
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
Rajesh K. Thimmulappa,Kim H. Mai,Sorachai Srisuma,Thomas W. Kensler,Masayuki Yamamoto,Shyam Biswal +5 more
TL;DR: This investigation expands the horizon of Nrf2-regulated genes, highlights the cross-talk between various metabolic pathways, and divulges the pivotal role played by NRF2 in regulating cellular defenses against carcinogens and other toxins.
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Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation.
TL;DR: The Nrf2-Keap1 system is present not only in mammals, but in fish, suggesting that its roles in cellular defense are conserved throughout evolution among vertebrates.
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Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1.
Akira Kobayashi,Moon Il Kang,Yoriko Watai,Kit I. Tong,Takahiro Shibata,Koji Uchida,Masayuki Yamamoto +6 more
TL;DR: The contention that Nrf2 protein synthesized de novo after exposure to stress accumulates in the nucleus by bypassing the Keap1 gate supports the contention that the sensory mechanism of oxidative and electrophilic stresses is closely linked to the degradation mechanism of NRF2.