The complexity of the serine glycine one-carbon pathway in cancer.
TLDR
The role of one-carbon metabolism in tumorigenesis is reviewed and it is shown that perturbations in cellular metabolism are ubiquitous in cancer.Abstract:
The serine glycine and one-carbon pathway (SGOCP) is a crucially important metabolic network for tumorigenesis, of unanticipated complexity, and with implications in the clinic. Solving how this network is regulated is key to understanding the underlying mechanisms of tumor heterogeneity and therapy resistance. Here, we review its role in cancer by focusing on key enzymes with tumor-promoting functions and important products of the SGOCP that are of physiological relevance for tumorigenesis. We discuss the regulatory mechanisms that coordinate the metabolic flux through the SGOCP and their deregulation, as well as how the actions of this metabolic network affect other cells in the tumor microenvironment, including endothelial and immune cells.read more
Citations
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Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells
TL;DR: It is shown that human ESCs/iPSCs require high amounts of methionine (Met) and express high levels of enzymes involved in Met metabolism, and SAM is a key regulator for maintaining undifferentiated pluripotent stem cells and regulating their differentiation.
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway
Xin Gu,Jose M. Orozco,Robert A. Saxton,Kendall J. Condon,Grace Y. Liu,Patrycja A. Krawczyk,Sonia M. Scaria,J. Wade Harper,Steven P. Gygi,David M. Sabatini +9 more
TL;DR: A potential molecular link between the effects of methionine restriction and the growth controller mTOR complex 1 (mTORC1), a well-validated regulator of life span and health span in many organisms is described and a protein named SAMTOR is identified as a component of the nutrient-sensing pathway upstream of m TORC1.
Journal ArticleDOI
Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation.
TL;DR: In this paper, a shift from oxidative phosphorylation to aerobic glycolysis to support the increased need for ATP, increased glutaminolysis for NADPH regeneration, altered flux through the pentose phosphate pathway and the tricarboxylic acid cycle for macromolecule generation, increased lipid uptake, lipogenesis, and cholesterol synthesis, upregulation of one-carbon metabolism for the production of ATP, NADH/NADPH, nucleotides, and glutathione, altered amino acid metabolism, metabolism-based regulation of apoptosis, and
Journal ArticleDOI
Characterization of Metabolic Patterns in Mouse Oocytes during Meiotic Maturation.
Ling Li,Shuai Zhu,Wenjie Shu,Yueshuai Guo,Yusheng Guan,Juan Zeng,Haichao Wang,Longsen Han,Jiaqi Zhang,Xiaohui Liu,Chunling Li,Xiaojing Hou,Min Gao,Juan Ge,Chao Ren,Hao Zhang,Tim Schedl,Xuejiang Guo,Minjian Chen,Qiang Wang +19 more
TL;DR: The temporal metabolome profiles of mouse oocytes during in-vivo maturation are obtained by isolating large number of cells at key stages by identifying the key targets mediating the action of PUFA arachidonic acid on meiotic maturation and the control of epigenetic marks in maturing oocytes by SGOC network.
Journal ArticleDOI
Serine, glycine and one‑carbon metabolism in cancer (Review).
TL;DR: The role of key enzymes with tumor-promoting functions and important intermediates that are physiologically relevant to tumorigenesis in serine/glycine/one-carbon metabolism pathways are reviewed.
References
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Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
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The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
Peter Walter,David Ron +1 more
TL;DR: The vast majority of proteins that a cell secretes or displays on its surface first enter the endoplasmic reticulum, where they fold and assemble, and only properly assembled proteins advance from the ER to the cell surface.
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Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
TL;DR: The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours.
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Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Heather P. Harding,Isabel Novoa,Yuhong Zhang,Huiqing Zeng,Ronald C. Wek,Matthieu Schapira,David Ron +6 more
TL;DR: Protein kinases that phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) are activated in stressed cells and negatively regulate protein synthesis, resulting in the induction of the downstream gene CHOP (GADD153).
Journal ArticleDOI
Understanding the Intersections between Metabolism and Cancer Biology
TL;DR: In this paper, the authors define pathways that are limiting for cancer progression and understand the context specificity of metabolic preferences and liabilities in malignant cells, which can guide the more effective targeting of metabolism to help patients.
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