The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis
Vajiheh Rangboo,Mostafa Noroozi,Roza Zavoshy,Seyed Amirmansoor Rezadoost,Asghar Mohammadpoorasl +4 more
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TLDR
Light is shed on the potential hepatoprotective activity and hypolipidemic effect of Cynara scolymus in management of NASH and changes in study markers following interventions showed improvement in liver enzymes.Abstract:
Background. Based on recent basic and clinical investigations, the extract of artichoke (Cynara scolymus) leaf has been revealed to be used for hepatoprotective and cholesterol reducing purposes. We aimed to assess the therapeutic effects of artichoke on biochemical and liver biomarkers in patients with nonalcoholic steatohepatitis (NASH). Methods. In a randomized double blind clinical trial, 60 consecutive patients suffering NASH were randomly assigned to receive Cynara scolymus extract (as 6 tablets per day consisting of 2700 mg extract of the herb) as the intervention group or placebo as the control group for two months. Results. Comparing changes in study markers following interventions showed improvement in liver enzymes. The levels of triglycerides and cholesterol were significantly reduced in the group treated with Cynara scolymus when compared to placebo group. To compare the role of Cynara scolymus use with placebo in changes in study parameters, multivariate linear regression models were employed indicating higher improvement in liver enzymes and also lipid profile particularly triglycerides and total cholesterol following administration of Cynara scolymus in comparison with placebo use. Conclusion. This study sheds light on the potential hepatoprotective activity and hypolipidemic effect of Cynara scolymus in management of NASH. This clinical trial is registered in the IRCT, Iranian Registry of Clinical Trials, by number IRCT2014070218321N1.read more
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Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel.
Arrigo F G Cicero,Alessandro Colletti,Gani Bajraktari,Olivier Descamps,Dragan M. Djuric,Marat V. Ezhov,Zlatko Fras,Niki Katsiki,Michel Langlois,Gustavs Latkovskis,Demosthenes B. Panagiotakos,György Paragh,Dimitri P. Mikhailidis,Olena Mitchenko,Bernhard Paulweber,Daniel Pella,Christos Pitsavos,Željko Reiner,Kausik K. Ray,Manfredi Rizzo,Amirhossein Sahebkar,Maria-Corina Serban,Laurence S. Sperling,Peter P. Toth,Dragos Vinereanu,Michal Vrablík,Nathan D. Wong,Maciej Banach +27 more
TL;DR: The purpose of this position paper is to provide consensus-based recommendations for the optimal use of lipid-lowering nutraceuticals to manage dyslipidemia in patients who are still not on statin therapy, patients who have not achieved lipid goals, and patients with statin intolerance.
Journal ArticleDOI
The Role of Nutraceuticals in Statin Intolerant Patients
Maciej Banach,Angelo Maria Patti,Rosaria Vincenza Giglio,Arrigo F G Cicero,Atanas G. Atanasov,Atanas G. Atanasov,Gani Bajraktari,Eric Bruckert,Olivier S. Descamps,Dragan M. Djuric,Marat V. Ezhov,Zlatko Fras,Stephan von Haehling,Niki Katsiki,Michel Langlois,Gustavs Latkovskis,G.B. John Mancini,Dimitri P. Mikhailidis,Olena Mitchenko,Patrick M. Moriarty,Paul Muntner,Dragana Nikolic,Demosthenes B. Panagiotakos,György Paragh,Bernhard Paulweber,Daniel Pella,Christos Pitsavos,Željko Reiner,Giuseppe M.C. Rosano,Robert S. Rosenson,Jacek Rysz,Amirhossein Sahebkar,Maria-Corina Serban,Dragos Vinereanu,Michal Vrablík,Gerald F. Watts,Nathan D. Wong,Manfredi Rizzo +37 more
TL;DR: The aim of this expert opinion paper is to provide the first attempt at recommendation on the management of statin intolerance through the use of nutraceuticals with particular attention on those with effective low-density lipoprotein cholesterol reduction.
Journal ArticleDOI
Lipid lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel.
Arrigo F G Cicero,Alessandro Colletti,Gani Bajraktari,Olivier Descamps,Dragan M. Djuric,Marat V. Ezhov,Zlatko Fras,Niki Katsiki,Michel Langlois,Gustavs Latkovskis,Demosthenes B. Panagiotakos,György Paragh,Dimitri P. Mikhailidis,Olena Mitchenko,Bernhard Paulweber,Daniel Pella,Christos Pitsavos,Željko Reiner,Kausik K. Ray,Manfredi Rizzo,Amirhossein Sahebkar,Maria-Corina Serban,Laurence S. Sperling,Peter P. Toth,Dragos Vinereanu,Michal Vrablík,Nathan D. Wong,Maciej Banach +27 more
TL;DR: This research presents a novel and scalable approach called “SmartCardiology,” which aims to provide real-time information about the activity of the autonomic nervous system and its role in cardiac arrest.
Journal ArticleDOI
Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis
Amirhossein Sahebkar,Matteo Pirro,Maciej Banach,Dimitri P. Mikhailidis,Stephen L. Atkin,Arrigo F G Cicero +5 more
TL;DR: Benefit of supplementation with artichoke extract was associated with a significant reduction in both total and LDL-C, and triglycerides, suggesting that supplementation may be synergistic with lipid-lowering therapy in patients with hyperlipidemia.
Journal ArticleDOI
The effect of artichoke on lipid profile: A review of possible mechanisms of action.
TL;DR: The main potential of ALE administration observed on lipid profile relates to decreased serum LDL, total cholesterol and triglyceride concentrations, although no strong evidence for increasing HDL appears to exist.
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