Journal ArticleDOI
The evolving classification of soft tissue tumours – an update based on the new 2013 WHO classification
TLDR
A brief overview summarizes changes in the classification in each of the broad categories of soft tissue tumour (adipocytic, fibroblastic, etc.) and also provides a short summary of newer genetic data which have been incorporated in the WHO classification.Abstract:
The new World Health Organization (WHO) classification of soft tissue tumours was published in early 2013, almost 11 years after the previous edition. While the number of newly recognized entities included for the first time is fewer than that in 2002, there have instead been substantial steps forward in molecular genetic and cytogenetic characterization of this family of tumours, leading to more reproducible diagnosis, a more meaningful classification scheme and providing new insights regarding pathogenesis, which previously has been obscure in most of these lesions. This brief overview summarizes changes in the classification in each of the broad categories of soft tissue tumour (adipocytic, fibroblastic, etc.) and also provides a short summary of newer genetic data which have been incorporated in the WHO classification.read more
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Journal ArticleDOI
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
TL;DR: The history of investigations into pericytes, the mural cells of blood microvessels, are reviewed, emerging concepts are indicated, and problems and promise are pointed out.
Journal ArticleDOI
Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort
Sigbjørn Smeland,Stefan S. Bielack,Jeremy Whelan,Mark L. Bernstein,Pancras C.W. Hogendoorn,Mark Krailo,Richard Gorlick,Katherine A. Janeway,Fiona C. Ingleby,Jakob K. Anninga,Imre Antal,Carola A.S. Arndt,Kenneth L.B. Brown,Trude Butterfass-Bahloul,Gabriele Calaminus,Michael Capra,Catharina Dhooge,Mikael Eriksson,Adrienne M. Flanagan,Godehard Friedel,Mark C. Gebhardt,Hans Gelderblom,Robert E. Goldsby,Holcombe E. Grier,R Grimer,Douglas S. Hawkins,Stefanie Hecker-Nolting,Kirsten Sundby Hall,Michael S. Isakoff,Gordana Jovic,Thomas Kühne,Leo Kager,Thekla von Kalle,Edita Kabickova,Susanna Lang,Ching C. Lau,Patrick J. Leavey,Stephen L. Lessnick,Leo Mascarenhas,Regine Mayer-Steinacker,Paul A. Meyers,Raj Nagarajan,R. Lor Randall,Peter Reichardt,Marleen Renard,Catherine Rechnitzer,Cindy L. Schwartz,Sandra J. Strauss,Lisa A. Teot,Beate Timmermann,Matthew R. Sydes,Neyssa Marina +51 more
TL;DR: Survival rates from >2000 patients registered to EURAMOS-1 demonstrated survival rates in concordance with institution- or group-level osteosarcoma trials, and known prognostic factors were reaffirmed.
Journal ArticleDOI
Soft tissue sarcoma across the age spectrum: A population-based study from the surveillance epidemiology and end results database†
Andrea Ferrari,Iyad Sultan,Tseng Tien Huang,Carlos Rodriguez-Galindo,Ahmad Shehadeh,Cristina Meazza,Kirsten K. Ness,Michela Casanova,Sheri L. Spunt +8 more
TL;DR: Soft tissue sarcomas are a heterogeneous group of mesenchymal malignancies that occur throughout the lifespan and the impact of age on disease features and outcome is unclear.
Journal ArticleDOI
Side population cells isolated from mesenchymal neoplasms have tumor initiating potential.
Colleen Wu,Qingxia Wei,Velani Utomo,Puviindran Nadesan,Heather Whetstone,Rita A. Kandel,Jay S. Wunder,Benjamin A. Alman +7 more
TL;DR: A subpopulation of cells within a broad range of benign and malignant mesenchymal tumors with tumor-initiating capacity is identified and it is suggested that therapeutically targeting this sub population of cells could be used to improve patient outcome.
Journal ArticleDOI
Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor
Min S. Park,Shreyaskumar Patel,Joseph A. Ludwig,Jonathan C. Trent,Charles A. Conrad,Alexander J. Lazar,Wei Lien Wang,Piyaporn Boonsirikamchai,Haesun Choi,Xuemei Wang,Robert S. Benjamin,Dejka M. Araujo +11 more
TL;DR: Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy.
References
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Pathology and genetics of tumors of soft tissue and bone
TL;DR: This list includes tumours of undefined neoplastic nature, which are of uncertain differentiation Bone Tumours, Ewing sarcoma/Primitive neuroedtodermal tumour, Myogenic, lipogenic, neural and epithelial tumours, and others.
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NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors
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Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing
Dan R. Robinson,Yi-Mi Wu,Shanker Kalyana-Sundaram,Shanker Kalyana-Sundaram,Xuhong Cao,Robert J. Lonigro,Yun Shao Sung,Chun-Liang Chen,Lei Zhang,Rui Wang,Fengyun Su,Matthew K. Iyer,Sameek Roychowdhury,Javed Siddiqui,Kenneth J. Pienta,Lakshmi P. Kunju,Moshe Talpaz,Juan Miguel Mosquera,Samuel Singer,Scott M. Schuetze,Cristina R. Antonescu,Arul M. Chinnaiyan +21 more
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Journal ArticleDOI
Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics
TL;DR: STAT6 is a highly sensitive and almost perfectly specific immunohistochemical marker for SFT and can be helpful to distinguish this tumor type from histologic mimics.
Journal ArticleDOI
Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature.
Andrew L. Folpe,Julie C. Fanburg-Smith,Steven D. Billings,Michele Bisceglia,Franco Bertoni,Justin Cho,Michael J. Econs,Carrie Y. Inwards,Suzanne M. Jan de Beur,Thomas Mentzel,Elizabeth A. Montgomery,Michal Michal,Markku Miettinen,Stacey E. Mills,John D. Reith,John X. O'Connell,Andrew E. Rosenberg,Brian P. Rubin,Donald E. Sweet,Tuyethoa N. Vinh,Lester E. Wold,B. Wehrli,Kenneth E. White,Richard J. Zaino,Sharon W. Weiss +24 more
TL;DR: Most cases of mesenchymal tumor-associated OO, both in the present series and in the reported literature, are due to PMTMCT, and improved recognition of their histologic spectrum, including the presence of bone or osteoid-like matrix in otherwise typical cases and the existence of malignant forms, should allow distinction from other meschymal tumors.
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