The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease
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TLDR
Together, these studies set the scene for applying the knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.Abstract:
Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.read more
Citations
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Journal ArticleDOI
Functional analysis of Casein Kinase 1 in a minimal circadian system
Gerben van Ooijen,Matthew Hindle,Sarah F. Martin,Martin E. Barrios-Llerena,Frédéric Sanchez,François-Yves Bouget,John S. O’Neill,Thierry Le Bihan,Andrew J. Millar +8 more
TL;DR: Modulation of CK1 function lengthens circadian rhythms in Ostreococcus tauri, a unicellular marine algal species at the base of the green lineage, separated from humans by ~1.5 billion years of evolution.
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Common genetic variants in ARNTL and NPAS2 and at chromosome 12p13 are associated with objectively measured sleep traits in the elderly.
Daniel S. Evans,Neeta Parimi,Caroline M. Nievergelt,Terri Blackwell,Susan Redline,Sonia Ancoli-Israel,Eric S. Orwoll,Steven R. Cummings,Katie L. Stone,Gregory J. Tranah +9 more
TL;DR: Findings support a role for common genetic variation in clock genes in the regulation of inter-related sleep traits in the elderly.
Journal ArticleDOI
Alterations of circadian clockworks during differentiation and apoptosis of rat ovarian cells
Guiyan Chu,Kaoru Yoshida,Sayoko Narahara,Miho Uchikawa,Madoka Kawamura,Nobuhiko Yamauchi,Yongmei Xi,Yasufumi Shigeyoshi,Seiichi Hashimoto,Masa-aki Hattori +9 more
TL;DR: The results strongly suggest the circadian clockwork alters in ovarian cells during follicular development, luteinization, and apoptosis, and expression of Bmal1 may be related to the switch-on and switch-off of the circadian oscillation.
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Circadian oscillator proteins across the kingdoms of life: structural aspects
TL;DR: This review covers the structural aspects of circadian oscillators, and serves as a primer for this exciting realm of structural biology.
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PER2 Variation is Associated with Diurnal Preference in a Korean Young Population
Heon Jeong Lee,Leen Kim,Seung Gul Kang,Ho Kyoung Yoon,Jung Eun Choi,Young-Min Park,Seog Ju Kim,Daniel F. Kripke +7 more
TL;DR: Genotype and allele carrier status of a PER2 G3853A polymorphism (rs934945) were associated with CSM scores, indicating that rs9 34945 of PER2 may be associated with diurnal preference in a Korean healthy population.
References
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