The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease
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TLDR
Together, these studies set the scene for applying the knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.Abstract:
Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.read more
Citations
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Central and Peripheral Circadian Clocks in Mammals
TL;DR: An emerging view for the adaptive significance of circadian clocks is their fundamental role in orchestrating metabolism.
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Circadian Integration of Metabolism and Energetics
Joseph Bass,Joseph S. Takahashi +1 more
TL;DR: Advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes are reviewed and implications for rational therapeutics for these conditions are reviewed.
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Transcriptional architecture of the mammalian circadian clock
TL;DR: Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling.
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Control of Sleep and Wakefulness
TL;DR: Genetic studies suggest that brain mechanisms controlling waking and NREM sleep are strongly conserved throughout evolution, underscoring their enormous importance for brain function.
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Suprachiasmatic Nucleus: Cell Autonomy and Network Properties
TL;DR: The SCN network synchronizes its component cellular oscillators, reinforces their oscillations, responds to light input by altering their phase distribution, increases their robustness to genetic perturbations, and enhances their precision.
References
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TL;DR: A comparative analysis of circadian gene expression in vivo in mouse liver and heart using oligonucleotide arrays representing 12,488 genes finds that peripheral circadian gene regulation is extensive, that the distributions of circadian phases in the two tissues are markedly different, and that very few genes show circadian regulation in both tissues.
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TL;DR: In this article, the intrinsic period of the human circadian pacemaker averages 24.18 hours in both age groups, with a tight distribution consistent with other species, with important implications for understanding the pathophysiology of disrupted sleep in older people.
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Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals
Maureen K. Bunger,Lisa D. Wilsbacher,Susan M. Moran,Cynthia Clendenin,Laurel A. Radcliffe,John B. Hogenesch,M. Celeste Simon,Joseph S. Takahashi,Christopher A. Bradfield +8 more
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