The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease
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TLDR
Together, these studies set the scene for applying the knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.Abstract:
Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.read more
Citations
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Journal ArticleDOI
Dysregulation of CLOCK gene expression in hyperoxia-induced lung injury
Venu Lagishetty,Prasanna Tamarapu Parthasarathy,Oluwakemi Phillips,Jutaro Fukumoto,Young Ae Cho,Itsuko Fukumoto,Huynh Bao,Ruan Cox,Lakshmi Galam,Richard F. Lockey,Narasaiah Kolliputi +10 more
TL;DR: It is demonstrated that hyperoxia-mediated lung inflammation is associated with alterations in CLock gene expression, and data suggest a dose-dependent increase in CLOCK gene expression with increased oxygen concentrations.
Journal ArticleDOI
Early chronotype and tissue-specific alterations of circadian clock function in spontaneously hypertensive rats.
TL;DR: The results revealed that SHR exhibited an early chronotype, because the central SCN clock was phase advanced relative to light/dark cycle and the SCN driven output rhythm ran faster compared to Wistar rats, and the output rhythm was dampened.
Journal ArticleDOI
O-GlcNAcylation of BMAL1 regulates circadian rhythms in NIH3T3 fibroblasts.
TL;DR: BMAL1 was modified with an O-linked β-N-acetylglucosamine (O-GlcNAc), which stabilized BMAL1 and enhanced its transcriptional activity, and inhibition of O- GlcNAcylation resulted in inhibition of circadian rhythms of clock gene expression.
Journal ArticleDOI
Association of Tef polymorphism with depression in Parkinson disease
Ping Hua,Weiguo Liu,Sheng-Han Kuo,Yanyan Zhao,Ling Chen,Ning Zhang,Chun Wang,Suwan Guo,Li Wang,Hong Xiao,Justin Y. Kwan,Tianxia Wu +11 more
TL;DR: Three polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression and the relationship between these genes and depression symptoms in Parkinson's disease has not been established.
Journal ArticleDOI
Circadian neurogenetics of mood disorders
Jorge Mendoza,Guillaume Vanotti +1 more
TL;DR: The present review describes the current evidence that implicates the clock gene alterations as an important factor in the development of mood-related disorders and describes the possible role of other brain clocks, beyond the SCN, in the circadian control of mood.
References
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Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
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TL;DR: Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components, and major processes regulated by the SCN and liver were found to be under circadian regulation.
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