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Open AccessJournal ArticleDOI

The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease

Joseph S. Takahashi, +3 more
- 01 Oct 2008 - 
- Vol. 9, Iss: 10, pp 764-775
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TLDR
Together, these studies set the scene for applying the knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.
Abstract: 
Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.

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Citations
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Journal ArticleDOI

Unconjugated Bile Acids Influence Expression of Circadian Genes: A Potential Mechanism for Microbe-Host Crosstalk.

Kalaimathi Govindarajan, +5 more
- 01 Dec 2016 - 
TL;DR: Oral administration of mice with unconjugated bile acids significantly altered expression levels of circadian clock genes in the ileum and colon as well as the liver with significant changes to expression of hepatic regulators of circadian rhythm (including Dbp, Per2, Per3 and Cry2).
Journal ArticleDOI

Diverse types of ganglion cell photoreceptors in the mammalian retina

Andrea Sand, +2 more
- 01 Jul 2012 - 
TL;DR: Over the past decade or so, it has become apparent that these photoreceptors are distinguishable as individual subtypes on the basis of their morphology, molecular markers, functional properties, and efferent projections.
Journal ArticleDOI

CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.

Louise K. Sjöholm, +5 more
- 21 Jan 2010 - 
TL;DR: The findings suggest an association between the CLOCK gene and the comorbid condition of alcohol use and depressive disorders, and indicates that the CLock variations found here may be a vulnerability factor to depression given the exposure to alcohol in individuals having AUD.
Journal ArticleDOI

Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes

Hao A. Duong, +1 more
- 01 Feb 2014 - 
TL;DR: It is found that mouse PER complexes include the histone methyltransferase HP1γ–Suv39h, which proved important for circadian di- and trimethylation of histone H3 Lys9 at the Per1 promoter, feedback repression and clock function.
Journal ArticleDOI

Evidence Suggesting that the Cardiomyocyte Circadian Clock Modulates Responsiveness of the Heart to Hypertrophic Stimuli in Mice

David J. Durgan, +13 more
- 31 Mar 2011 - 
TL;DR: Chronic dyssychrony of the cardiomyocyte circadian clock with its environment would precipitate myocardial maladaptation to a circadian challenge (simulated shiftwork; SSW).
References
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Journal Article

A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms.

James Horne, +1 more
- 01 Jan 1976 - 
TL;DR: Although the questionnaire appears to be valid, further evaluation using a wider subject population is required, as sleep habits are an important déterminant of peak time there are other contibutory factors, and these appear to be partly covered by the questionnaire.
Journal ArticleDOI

The role of actigraphy in the study of sleep and circadian rhythms.

Sonia Ancoli-Israel, +5 more
- 01 May 2003 - 
TL;DR: It is suggested that in the clinical setting, actigraphy is reliable for evaluating sleep patterns in patients with insomnia, for studying the effect of treatments designed to improve sleep, in the diagnosis of circadian rhythm disorders (including shift work), and in evaluating sleep in individuals who are less likely to tolerate PSG, such as infants and demented elderly.
Journal ArticleDOI

Hypothalamic regulation of sleep and circadian rhythms

Clifford B. Saper, +2 more
- 27 Oct 2005 - 
TL;DR: These findings explain how various drugs affect sleep and wakefulness, and provide the basis for a wide range of environmental influences to shape wake–sleep cycles into the optimal pattern for survival.
Journal ArticleDOI

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

Fred W. Turek, +19 more
- 13 May 2005 - 
TL;DR: Estimation of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice, suggesting that the circadian clock gene network plays an important role in mammalian energy balance.
Journal ArticleDOI

Coordinated transcription of key pathways in the mouse by the circadian clock.

Satchidananda Panda, +12 more
- 03 May 2002 - 
TL;DR: Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components, and major processes regulated by the SCN and liver were found to be under circadian regulation.
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Coordinated transcription of key pathways in the mouse by the circadian clock.

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The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator.

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Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

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