The Genetics of Mammalian Circadian Order and Disorder: Implications for Physiology and Disease
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TLDR
Together, these studies set the scene for applying the knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.Abstract:
Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.read more
Citations
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Circadian rhythms and cancer.
Sigal Gery,H. Phillip Koeffler +1 more
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Circadian and sleep disorder in Huntington's disease.
TL;DR: A better understanding of the relationship between sleep/circadian abnormalities and HD pathology is needed, if treatment of this aspect of HD is to be optimized.
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Interactions of the serotonin and circadian systems: nature and nurture in rhythms and blues.
TL;DR: The neuroanatomical and genetic basis for serotonin-circadian interactions in the brain, their potential relationship with neurobehavioral disorders, and recent work examining the effects on the circadian system of genetic perturbation of the serotonergic system are reviewed.
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Melanopsin and the Intrinsically Photosensitive Retinal Ganglion Cells: Biophysics to Behavior.
TL;DR: The study of ipRGCs has yielded insight into general topics that include photoreceptor evolution, cellular diversity, and the steps from biophysical mechanisms to behavior.
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