Journal ArticleDOI
The human milk microbiome: who, what, when, where, why, and how?
Lisa F Stinson,Azhar S M Sindi,Ali S Cheema,Ching Tat Lai,Beverly S. Muhlhausler,Mary E. Wlodek,Matthew S. Payne,Donna T. Geddes +7 more
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TLDR
By gaining a deeper understanding of the HM microbiome, opportunities to intervene to optimize infant and lifelong health may be identified and avenues for further research are highlighted.Abstract:
Human milk (HM) contains an incredible array of microorganisms. These likely contribute to the seeding of the infant gastrointestinal microbiome, thereby influencing infant immune and metabolic development and later-life health. Given the importance of the HM microbiota in this context, there has been an increase in research efforts to characterize this in different populations and in relation to different maternal and infant characteristics. However, despite a decade of intensive research, there remain several unanswered questions in this field. In this review, the "5 W+H" approach (who, what, when, where, why, and how) is used to comprehensively describe the composition, function, and origin of the HM microbiome. Here, existing evidence will be drawn together and critically appraised to highlight avenues for further research, both basic and applied. Perhaps the most interesting of these is the potential to modulate the HM microbiome using pre/probiotics or dietary interventions. Another exciting possibility is the personalization of donor milk for women with insufficient supply. By gaining a deeper understanding of the HM microbiome, opportunities to intervene to optimize infant and lifelong health may be identified.read more
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Human milk composition promotes optimal infant growth, development and health.
Sharon L. Perrella,Zoya Gridneva,Ching Tat Lai,Lisa F Stinson,Alexandra D George,Sabrina H. Bilston-John,Donna T. Geddes +6 more
TL;DR: A review on the diverse range of nutrients, immune protection factors, hormones, microbes and metabolites in human milk and their impacts on infant nutrition and health is presented in this paper, where the authors consider human milk as a living dynamic fluid that promotes optimal nutrition and development of the infant and impacts health across the lifespan.
Journal ArticleDOI
Can we modulate the breastfed infant gut microbiota through maternal diet
Azhar S M Sindi,Azhar S M Sindi,Donna T. Geddes,Mary E. Wlodek,Beverly S. Muhlhausler,Beverly S. Muhlhausler,Matthew S. Payne,Lisa F Stinson +7 more
TL;DR: The role of maternal dietary patterns during lactation in shaping infant gut microbial composition and function has been investigated in this paper, which suggests that modulation of the maternal gut microbiota, via diet or probiotics, may influence the mammary or milk microbiota.
Journal ArticleDOI
25 Years of Research in Human Lactation: From Discovery to Translation
Donna T. Geddes,Zoya Gridneva,Sharon L. Perrella,Leon R. Mitoulas,Jacqueline C. Kent,Lisa F Stinson,Ching Tat Lai,Vanessa S. Sakalidis,Alecia-Jane Twigger,Peter E. Hartmann +9 more
TL;DR: In this paper, a biological system approach traversing breast anatomy, milk secretion, physiology of milk removal with respect to breastfeeding and expression, milk composition and infant intake, and infant gastric emptying, culminating in the exploration of relationships with infant growth, development of body composition, and health.
Journal ArticleDOI
Emerging Roles of Gut Virome in Pediatric Diseases.
TL;DR: In the last decade, the widespread application of shotgun metagenomics provided extensive characterization of the bacterial "dark matter" of the gut microbiome, propelling the development of dedicated, standardized bioinformatic pipelines and the systematic collection of metagenomic data into comprehensive databases as discussed by the authors.
Journal ArticleDOI
Composition of Human Breast Milk Microbiota and Its Role in Children’s Health
TL;DR: HMM is an important contributor to gastrointestinal colonization in children and therefore, it is fundamental to avoid any form of perturbation in the HMM that can alter the microbial equilibrium, especially in the first 100 days of life.
References
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Journal ArticleDOI
Factors influencing the composition of the intestinal microbiota in early infancy
John Penders,Carel Thijs,Carel Thijs,Cornelis Vink,Foekje Stelma,Bianca E. P. Snijders,Ischa Kummeling,Piet A. van den Brandt,Ellen E. Stobberingh +8 more
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