The lymphatic drainage systems in the brain: a novel target for ischemic stroke?
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TLDR
The basic concepts of these drainage systems, including drainage routes, physiological functions, regulatory mechanisms, and detection technologies, are summarized and information for potential novel strategies for treatment of stroke is provided.About:
This article is published in Neural Regeneration Research.The article was published on 2022-06-02 and is currently open access. It has received 6 citations till now. The article focuses on the topics: Medicine & Glymphatic system.read more
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Mechanism of neocryptotanshinone in protecting against cerebral ischemic injury: By suppressing M1 polarization of microglial cells and promoting cerebral angiogenesis.
TL;DR: Zhang et al. as discussed by the authors explored the protective function and mechanism of neocryptotanshinone (NEO) on cerebral ischemia and found that NEO suppressed M1 polarization of BV2 cells, which exerted its effect through suppressing NF-κB and STAT3 signals, thereby decreasing the levels of iNOS, CD11b and inflammatory factors.
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Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders
TL;DR: In this paper , the authors summarize the pathophysiological role that aquaporin-4 plays in several CNS disorders by affecting the clearance function of the glymphatic system and provide new therapeutic alternatives for incurable debilitating neurodegenerative disorders of CNS in the future.
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DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke
Yue Qin,Xin Li,Yanqiang Qiao,Huili Zou,Yifan Qian,Xiaoshi Li,Yinhu Zhu,W.-j. Huo,Lei Wang,Ming Zhang +9 more
TL;DR: In this article , diffusion tensor image analysis along the perivascular space (DTI-ALPS) was used to explore whether glymphatic activity was related to motor dysfunction in subacute ischemic stroke patients.
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Update April 2023.
TL;DR: Blei et al. as discussed by the authors published a volume 21 issue 2, No. 2 Literature Watch update April 20, 2023 with the title of "Lymphatic Research and Biology".
Journal ArticleDOI
Role of the Meningeal Lymphatics in Stroke
TL;DR: The role of meningeal lymphatic vessels (MLVs) in the immune response after ischemic stroke has been investigated in this paper , showing that MLVs act as a physical conduit for antigens and immune cells from the central nervous system to enter the draining cervical lymph nodes (CLNs).
References
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Journal ArticleDOI
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.
Jeffrey J. Iliff,Minghuan Wang,Minghuan Wang,Yonghong Liao,Benjamin A. Plogg,Weiguo Peng,Georg Andreas Gundersen,Helene Benveniste,G. Edward Vates,Rashid Deane,Steven A. Goldman,Erlend A. Nagelhus +11 more
TL;DR: An anatomically distinct clearing system in the brain that serves a lymphatic-like function is described and may have relevance for understanding or treating neurodegenerative diseases that involve the mis-accumulation of soluble proteins, such as amyloid β in Alzheimer's disease.
Journal ArticleDOI
Sleep Drives Metabolite Clearance From the Adult Brain
Lulu Xie,Hongyi Kang,Qiwu Xu,Michael Chen,Yonghong Liao,Meenakshisundaram Thiyagarajan,John O’Donnell,Daniel J. Christensen,Charles Nicholson,Jeffrey J. Iliff,Takahiro Takano,Rashid Deane +11 more
TL;DR: It is reported that sleep has a critical function in ensuring metabolic homeostasis and convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep, suggesting the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.
Journal ArticleDOI
Structural and functional features of central nervous system lymphatic vessels
Antoine Louveau,Igor Smirnov,Timothy J. Keyes,Jacob D. Eccles,Sherin J. Rouhani,J. David Peske,Noël C. Derecki,David Castle,James Mandell,Kevin S. Lee,Tajie H. Harris,Jonathan Kipnis +11 more
TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.
Journal ArticleDOI
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
Aleksanteri Aspelund,Salli Antila,Steven T. Proulx,Tine V. Karlsen,Sinem Karaman,Michael Detmar,Helge Wiig,Kari Alitalo +7 more
TL;DR: The presence of a lymphatic vessel network in the dura mater of the mouse brain is discovered and it is shown that these dural lymphatic vessels are important for the clearance of macromolecules from the brain.
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Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.
Geoffrey T. Manley,Miki Fujimura,Tonghui Ma,Nobuo Noshita,Ferda Filiz,Andrew W. Bollen,Pak H. Chan,Alan S. Verkman +7 more
TL;DR: It is shown that mice deficient in aquaporin-4 (AQP4), a glial membrane water channel, have much better survival than wild-type mice in a model of brain edema caused by acute water intoxication, and suggested that AQP4 inhibition may provide a new therapeutic option for reducingbrain edema in a wide variety of cerebral disorders.
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