Journal ArticleDOI
The molecular genetics and tumor pathogenesis of meningiomas and the future directions of meningioma treatments
Winward Choy,Won Kim,Daniel T. Nagasawa,Stephanie Stramotas,Andrew Yew,Quinton Gopen,Andrew T. Parsa,Isaac Yang +7 more
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TLDR
Treatment for meningiomas that are recurrent, aggressive, or refractory to conventional treatments will include combinations of targeted molecular agents as a result of continued progress in the understanding of genetic and biological changes associated withMeningioma.Abstract:
Meningiomas are mostly benign, slow-growing tumors of the CNS that originate from arachnoidal cap cells. While monosomy 22 is the most frequent genetic abnormality found in meningiomas, a multitude of other aberrant chromosomal alterations, signaling pathways, and growth factors have been implicated in its pathogenesis. Losses on 22q12.2, a region encoding the tumor suppressor gene merlin, represent the most common genetic alterations in early meningioma formation. Malignant meningioma progression, however, is associated with more complex karyotypes and greater genetic instability. Cytogenetic studies of atypical and anaplastic meningiomas revealed gains and losses on chromosomes 9, 10, 14, and 18, with amplifications on chromosome 17. However, the specific gene targets in a majority of these chromosomal abnormalities remain elusive. Studies have also implicated a myriad of aberrant signaling pathways involved with meningioma tumorigenesis, including those involved with proliferation, angiogenesis, and au...read more
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Journal ArticleDOI
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations
Priscilla K. Brastianos,Peleg M. Horowitz,Sandro Santagata,Sandro Santagata,Robert T. Jones,Aaron McKenna,Gad Getz,Keith L. Ligon,Keith L. Ligon,Emanuele Palescandolo,Paul Van Hummelen,Matthew D. Ducar,Alina Raza,Ashwini Sunkavalli,Laura E. MacConaill,Anat Stemmer-Rachamimov,David N. Louis,William C. Hahn,Ian F. Dunn,Ian F. Dunn,Ian F. Dunn,Rameen Beroukhim +21 more
TL;DR: The spectrum of genetic alterations in meningiomas is defined and potential therapeutic targets are identified to identify and validate somatic genetic alterations.
Journal ArticleDOI
An overview of meningiomas.
Robin A. Buerki,Craig Horbinski,Tim J. Kruser,Peleg M. Horowitz,Charles David James,Rimas V. Lukas +5 more
TL;DR: This review will cover the histo- and molecular pathology of meningiomas, including recent 2016 updates to the WHO classification of CNS tumors, and discuss clinical and radiographic presentation and therapeutic management.
Journal ArticleDOI
The role of radiotherapy following gross-total resection of atypical meningiomas
Ricardo J. Komotar,J. Bryan Iorgulescu,Daniel M.S. Raper,Eric C. Holland,Kathryn Beal,Mark H. Bilsky,Mark H. Bilsky,Cameron Brennan,Cameron Brennan,Viviane Tabar,Viviane Tabar,Jonathan H. Sherman,Yoshiya Yamada,Philip H. Gutin,Philip H. Gutin +14 more
TL;DR: A retrospective series supports the observation that postoperative radiotherapy likely results in lower recurrence rates of gross totally resected atypical meningiomas, and contributes to a growing number of series that support routine post surgical radiotherapy as an adjuvant treatment for these lesions.
Journal ArticleDOI
Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway.
Haitao Wang,Qishan Zhang,Qiang Wen,Yongxin Zheng,Philip Lazarovici,Hao Jiang,Jun Lin,Wenhua Zheng +7 more
TL;DR: This review summarizes the signaling regulating PRAS40 phosphorylation, as well as the dual function ofPRAS40 as substrate and inhibitor of mTORC1 upon growth factor stimulation and under pathophysiological conditions.
Journal ArticleDOI
Double-Blind Phase III Randomized Trial of the Antiprogestin Agent Mifepristone in the Treatment of Unresectable Meningioma: SWOG S9005.
Yongli Ji,Cathryn Rankin,Steven M. Grunberg,Andy Sherrod,Jamshid Ahmadi,Jeannette J. Townsend,Lynn G. Feun,Ruth K. Fredericks,Christy A. Russell,Fairooz F. Kabbinavar,Keith J. Stelzer,Anne F. Schott,Claire F. Verschraegen +12 more
TL;DR: Long-term administration of mifepristone was well tolerated but had no impact on patients with unresectable meningioma.
References
More filters
Journal ArticleDOI
The MAPK signaling cascade.
Rony Seger,Edwin G. Krebs +1 more
TL;DR: This review highlights primarily the first MAPK cascade to be discovered that uses the MEK and ERK isoforms and describes their involvement in different cellular processes, and it is now known that signaling pathways initiated by phorbol esters, iono‐phors, heat shock, and liganda for seven transmembrane receptors use distinct MAPK cascades with little or no cross‐reactivity between them.
Journal ArticleDOI
Defining the Role of mTOR in Cancer
TL;DR: Recent progress in understanding mTOR signaling is discussed, paying particular attention to its relevance in cancer and the use of rapamycin in oncology.
Book ChapterDOI
Signal transduction through MAP kinase cascades.
TL;DR: The chapter explores the cellular substrates of MAP kinases, wherein it discusses about protein kinase substrates for MAPKS, nuclear transcription factors, signaling components, and cytoskeletal proteins.
Journal ArticleDOI
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor
James A. Trofatter,Mia MacCollin,Joni L. Rutter,Jill R. Murrell,Mabel P. Duyao,Dilys M. Parry,Roswell Eldridge,Nikolai Kley,Anil G. Menon,K Pulaski,Volker H. Haase,Christine Ambrose,David J. Munroe,Catherine Bove,Jonathan L. Haines,Robert L. Martuza,Marcy E. MacDonald,Bernd R. Seizinger,M. Priscilla Short,Alan Buckler,James F. Gusella +20 more
TL;DR: A candidate gene for the NF2 tumor suppressor that has suffered nonoverlapping deletions in DNA from two independent NF2 families and alterations in meningiomas from two unrelated NF2 patients is identified.
Journal ArticleDOI
HES and HERP families: multiple effectors of the Notch signaling pathway.
TL;DR: The identification of the HERP family as a Notch effector that cooperates with HES/E(spl) family has opened a new avenue to the authors' understanding of the Notch signaling pathway.
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