Journal ArticleDOI
The neuroendocrinology of obesity
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TLDR
As the nosology of obesity improves, diagnostic efficiency and therapeutic success should increase, leading to a decrease in associated morbidity, mortality, and socioeconomic ramifications.About:
This article is published in Endocrinology and Metabolism Clinics of North America.The article was published on 2001-09-01. It has received 59 citations till now. The article focuses on the topics: Birth weight & Weight loss.read more
Citations
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Journal ArticleDOI
Metabolism disrupting chemicals and metabolic disorders
Jerrold J. Heindel,Bruce Blumberg,Mathew C. Cave,Ronit Machtinger,Alberto Mantovani,Michelle A. Mendez,Angel Nadal,Paola Palanza,Giancarlo Panzica,Robert M. Sargis,Laura N. Vandenberg,Frederick S. vom Saal +11 more
TL;DR: This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders.
Journal ArticleDOI
Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice.
Kristen A. Lantz,Susan G. Emeigh Hart,Sonia Lobo Planey,Mitchell F. Roitman,Inez Ruiz-White,Henry R. Wolfe,Michael Mclane +6 more
TL;DR: The data establish trodusquemine as an effective central and peripheral PTP1B inhibitor with the potential to elicit noncachectic fat‐specific weight loss and improve insulin and leptin levels.
Journal ArticleDOI
Obesity and endocrine disease
TL;DR: The fat cell has been found to be an endocrine organ that produces several peptides that are bioactive and participate in the regulation of adipocyte function that contributes to the development of obesity.
Journal ArticleDOI
The Hypothalamic - Pituitary -Adrenal Axis in the Neuroendocrine Regulation of Food Intake and Obesity: The Role of Corticotropin Releasing Hormone
TL;DR: The role of the hypothalamic-pituitary-adrenal axis in the control of food intake and the pathogenesis of obesity is reviewed and the interactions between other neurosystems and this hormonal axis are discussed.
Journal ArticleDOI
A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion
Robert H. Lustig,Frank L. Greenway,Pedro Velasquez-Mieyer,D Heimburger,D Schumacher,Diane K. Smith,W Smith,N Soler,Ghulam Warsi,William Berg,J Maloney,John Benedetto,W. Zhu,John Hohneker +13 more
TL;DR: It is indicated that Caucasian patients with the greater degree of insulin hypersecretion appeared to derive the most benefit from treatment, and the observed safety profile was consistent with the known effects of octreotide from previous studies.
References
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Chronic Central Leptin Infusion Enhances Insulin-Stimulated Glucose Metabolism and Favors the Expression of Uncoupling Proteins
I Cusin,K E Zakrzewska,Olivier Boss,Patrick Muzzin,J. P. Giacobino,Daniel Ricquier,Bernard Jeanrenaud,Françoise Rohner-Jeanrenaud +7 more
TL;DR: While leptin maintains or favors energy-dissipating mechanisms (UCP1, UCP2, and UCP3), the latter are markedly depressed in pair-fed rats, which may prevent subsequent excessive storage processes, thereby maintaining normal body homeostasis.
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The ciliary neurotrophic factor and its receptor, CNTFRα
Mark W. Sleeman,Keith D. Anderson,Philip D. Lambert,George D. Yancopoulos,Stanley J. Wiegand +4 more
TL;DR: The neuroprotective effects of CNTF have been demonstrated in a number of in vitro cell models as well as in vivo in mutant mouse strains which exhibit motor neuron degeneration.
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The effects of subdiaphragmatic vagotomy in rats with ventromedial hypothalamic obesity.
Shuji Inoue,George A. Bray +1 more
TL;DR: There was a positive correlation between the level of serum insulin and basal gastric acid in VMH lesioned rats which remained significant when the effects of food intake were held constant and supports the possibility that ventromedial hypothalamic injury is followed by enhanced vagal activity and that the vagus may play an important part in the hyperinsulinemia of VMH obesity.
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Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis
Gioacchino Calapai,Francesco Corica,Andrea Corsonello,Lidia Sautebin,Massimo Di Rosa,Giuseppe M. Campo,Michele Buemi,Vittorio Nicita Mauro,Achille P. Caputi +8 more
TL;DR: The results indicate that the L-arginine/NO pathway is involved in mediating leptin effects on feeding behavior, and demonstrate that nNOS activity is required for the effects of leptin on brain 5-HT turnover.
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Hypothalamic obesity : The autonomic hypothesis and the lateral hypothalamus.
G A Bray,S Inoue,Y Nishizawa +2 more
TL;DR: Several lines of evidence support the hypothesis that derangements in the function of the autonomic nervous system play an important role in the development of hypothalamic obesity, and implicate the VMH in the control of the sympathetic nervous system.