Journal ArticleDOI
Obesity and endocrine disease
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TLDR
The fat cell has been found to be an endocrine organ that produces several peptides that are bioactive and participate in the regulation of adipocyte function that contributes to the development of obesity.About:
This article is published in Endocrinology and Metabolism Clinics of North America.The article was published on 2003-12-01. It has received 161 citations till now. The article focuses on the topics: Adrenocorticotropic hormone & Endocrine disease.read more
Citations
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Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Eugenia E. Calle,Rudolf Kaaks +1 more
TL;DR: Gaining a better understanding of the relationship between obesity and cancer can provide new insight into mechanisms of cancer pathogenesis.
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Microbiota and SCFA in Lean and Overweight Healthy Subjects
Andreas Schwiertz,David Taras,Klaus Schäfer,Silvia Beijer,Nicolaas A. Bos,Christiane Donus,Philip D. Hardt +6 more
TL;DR: The results contradict previous reports with regard to the contribution of various bacterial groups to the development of obesity and this issue remains controversial.
Journal Article
Consensus statement : Childhood obesity
Phyllis W. Speiser,Mary C J Rudolf,Henry Anhalt,Cecilia Camacho-Hübner,Francesco Chiarelli,Michael Freemark,Annette Grüters,Eli Hershkovitz,Heiko Krude,Yael Latzer,Robert H. Lustig,Ora H. Pescovitz,Orit Pinhas-Hamiel,Alan D. Rogol,Shlomit Shalitin,Charles Sultan,Pnina Vardi,George A. Werther,Zvi Zadik,Nehama Zuckerman-Levin,Zeev Hochberg,James Whitcomb +21 more
TL;DR: In developing a consensus statement, this international group has presented the evidence, developed recommendations, and provided a platform aimed toward future corrective action and ongoing debate in the international community.
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Obesity and androgens: facts and perspectives
TL;DR: Given the fundamental role of sex hormones in the regulation of body composition, fuel homeostasis, and reproduction in humans, more emphasis should be placed on the potential role of androgen dysregulation in the pathophysiology of different obesity phenotypes and the metabolic syndrome.
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Obesity and infertility
TL;DR: In this paper, the authors summarized major factors affecting fertility in obesity and found that early onset of obesity favours the development of menses irregularities, chronic oligo-anovulation and infertility in the adult age.
References
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Journal ArticleDOI
Positional cloning of the mouse obese gene and its human homologue
Yiying Zhang,Ricardo Proenca,Ricardo Proenca,Margherita Maffei,Marisa Barone,Marisa Barone,Lori Leopold,Lori Leopold,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
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Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Yukio Arita,Shinji Kihara,Noriyuki Ouchi,Masahiko Takahashi,Kazuhisa Maeda,Jun-ichiro Miyagawa,Kikuko Hotta,Iichiro Shimomura,Tadashi Nakamura,Koji Miyaoka,Hiroshi Kuriyama,Makoto Nishida,Shizuya Yamashita,Kosaku Okubo,Kenji Matsubara,Masahiro Muraguchi,Yasuichi Ohmoto,Tohru Funahashi,Yuji Matsuzawa +18 more
TL;DR: Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
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A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
TL;DR: A novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation is described.
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Congenital leptin deficiency is associated with severe early-onset obesity in humans
C. T. Montague,I S Farooqi,Jonathan P. Whitehead,Maria A. Soos,Harald Rau,Nicholas J. Wareham,C. P. Sewter,JE Digby,S N Mohammed,J A Hurst,C H Cheetham,A R Earley,Anthony H. Barnett,Johannes B. Prins,Stephen O'Rahilly +14 more
TL;DR: The severe obesity found in two severely obese children who are members of the same highly consanguineous pedigree provides the first genetic evidence that leptin is an important regulator of energy balance in humans.
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A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Karine Clément,Christian Vaisse,Najiba Lahlou,Sylvie Cabrol,Véronique Pelloux,Dominique Cassuto,Micheline Gourmelen,Christian Dina,Jean Chambaz,Jean-Marc Lacorte,Arnaud Basdevant,Pierre Bougnères,Yves Lebouc,Philippe Froguel,Bernard Guy-Grand +14 more
TL;DR: A homozygous mutation in the human leptin receptor gene results in a truncated leptin receptor lacking both the transmembrane and the intracellular domains, which indicates that leptin is an important physiological regulator of several endocrine functions in humans.