Journal ArticleDOI
The neuroendocrinology of obesity
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TLDR
As the nosology of obesity improves, diagnostic efficiency and therapeutic success should increase, leading to a decrease in associated morbidity, mortality, and socioeconomic ramifications.About:
This article is published in Endocrinology and Metabolism Clinics of North America.The article was published on 2001-09-01. It has received 59 citations till now. The article focuses on the topics: Birth weight & Weight loss.read more
Citations
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Journal ArticleDOI
Metabolism disrupting chemicals and metabolic disorders
Jerrold J. Heindel,Bruce Blumberg,Mathew C. Cave,Ronit Machtinger,Alberto Mantovani,Michelle A. Mendez,Angel Nadal,Paola Palanza,Giancarlo Panzica,Robert M. Sargis,Laura N. Vandenberg,Frederick S. vom Saal +11 more
TL;DR: This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders.
Journal ArticleDOI
Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice.
Kristen A. Lantz,Susan G. Emeigh Hart,Sonia Lobo Planey,Mitchell F. Roitman,Inez Ruiz-White,Henry R. Wolfe,Michael Mclane +6 more
TL;DR: The data establish trodusquemine as an effective central and peripheral PTP1B inhibitor with the potential to elicit noncachectic fat‐specific weight loss and improve insulin and leptin levels.
Journal ArticleDOI
Obesity and endocrine disease
TL;DR: The fat cell has been found to be an endocrine organ that produces several peptides that are bioactive and participate in the regulation of adipocyte function that contributes to the development of obesity.
Journal ArticleDOI
The Hypothalamic - Pituitary -Adrenal Axis in the Neuroendocrine Regulation of Food Intake and Obesity: The Role of Corticotropin Releasing Hormone
TL;DR: The role of the hypothalamic-pituitary-adrenal axis in the control of food intake and the pathogenesis of obesity is reviewed and the interactions between other neurosystems and this hormonal axis are discussed.
Journal ArticleDOI
A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion
Robert H. Lustig,Frank L. Greenway,Pedro Velasquez-Mieyer,D Heimburger,D Schumacher,Diane K. Smith,W Smith,N Soler,Ghulam Warsi,William Berg,J Maloney,John Benedetto,W. Zhu,John Hohneker +13 more
TL;DR: It is indicated that Caucasian patients with the greater degree of insulin hypersecretion appeared to derive the most benefit from treatment, and the observed safety profile was consistent with the known effects of octreotide from previous studies.
References
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Journal ArticleDOI
From lesions to leptin: hypothalamic control of food intake and body weight.
TL;DR: The availability of these molecular tools, coupled with tract tracing, has resulted in striking progress in dissecting an extensive network of hypothalamic circuitry that regulates feeding, and the outline of the hypothalamic system for regulation of feeding is now more clear.
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Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
Jose F. Caro,Jerzy W. Kolaczynski,Mark R. Nyce,Joanna P. Ohannesian,Irina Opentanova,Warren H Goldman,Richard B. Lynn,Peili Zhang,Madhur K. Sinha,Robert V. Considine +9 more
TL;DR: The data suggest that leptin enters the brain by a saturable transport system, lower in obese individuals, and may provide a mechanism for leptin resistance.
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Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons
Stephen C. Woods,Stephen C. Woods,Elizabeth C. Lotter,Elizabeth C. Lotter,L. David McKay,L. David McKay,Daniel Porte,Daniel Porte +7 more
TL;DR: Additional evidence is presented by showing that in baboons the infusion of exogenous insulin into the CSF elicits a reliable and predictable decrease in food intake and body weight.
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Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
Robert S. Jackson,John W.M. Creemers,Shinya Ohagi,Marie-Laure Raffin-Sanson,Louise Sanders,C. T. Montague,John C. Hutton,Stephen O'Rahilly +7 more
TL;DR: It is inferred that molecular defects in prohormone conversion may represent a generic mechanism for obesity, common to humans and rodents.
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Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
TL;DR: SOCS-3 is a leptin-inducible inhibitor of leptin signaling, and a potential mediator of leptin resistance in Obesity, a model of leptin-resistant murine obesity.