Journal ArticleDOI
Genetics of body-weight regulation
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TLDR
The role of genetics in obesity is twofold: Studying rare mutations in humans and model organisms provides fundamental insight into a complex physiological process, and complements population-based studies that seek to reveal primary causes.Abstract:
The role of genetics in obesity is twofold. Studying rare mutations in humans and model organisms provides fundamental insight into a complex physiological process, and complements population-based studies that seek to reveal primary causes. Remarkable progress has been made on both fronts, and the pace of advance is likely to accelerate as functional genomics and the human genome project expand and mature. Approaches based on mendelian and quantitative genetics may well converge, and lead ultimately to more rational and selective therapies.read more
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Expert Committee Recommendations Regarding the Prevention, Assessment, and Treatment of Child and Adolescent Overweight and Obesity: Summary Report
TL;DR: These recommendations recognize the importance of social and environmental change to reduce the obesity epidemic but also identify ways healthcare providers and health care systems can be part of broader efforts.
Journal ArticleDOI
Obesity and the Regulation of Energy Balance
TL;DR: The last 5 years of the millennium have witnessed a dramatic increase in understanding of the biology of regulated energy balance and body weight, and insights from the sequencing of the human genome and the coming advances in proteomics are likely to fuel the next wave of progress.
Journal ArticleDOI
Gut hormone PYY 3-36 physiologically inhibits food intake
Rachel L. Batterham,Michael A. Cowley,Caroline J. Small,Herbert Herzog,Mark Cohen,C. L. Dakin,Alison M. Wren,Audrey E. Brynes,Malcolm J. Low,Mohammad A. Ghatei,Roger D. Cone,Stephen R. Bloom +11 more
TL;DR: In this paper, the authors showed that post-prandial elevation of PYY3-36 may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway.
Journal Article
BRIEF COMMUNICATION ARISING: Gut hormone PYY3-36 physiologically inhibits food intake
Rachel L. Batterham,Michael A. Cowley,Caroline J. Small,Herbert Herzog,Mark A Cohen,C. L. Dakin,Alison M. Wren,Audrey E. Brynes,Malcolm J. Low +8 more
TL;DR: The authors showed that post-prandial elevation of PYY3-36 may act through the arcuate nucleus Y2R to inhibit feeding in a gut-hypothalamic pathway.
Journal ArticleDOI
Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.
TL;DR: In this paper, the nucleotide sequence of the MC4R gene in 500 children with severe childhood obesity was determined, and the results were correlated with the signaling properties of mutant receptors.
References
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Book
Introduction to quantitative genetics
TL;DR: The genetic constitution of a population: Hardy-Weinberg equilibrium and changes in gene frequency: migration mutation, changes of variance, and heritability are studied.
Obesity : Preventing and managing the global epidemic
D. S. Akram,Arne Astrup,T. Atinmo,J. L. Boissin,George A. Bray,K. Carroll,P. Chitson,C. Chunming,William H. Dietz,James O. Hill,Eric Jéquier,C. Komodiki,Yuji Matsuzawa,W. F. Mollentze,K. Moosa,M.I. Noor,K.S. Reddy,Jacob C. Seidell,V. Tanphaichitr,Ricardo Uauy,Paul Zimmet +20 more
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Positional cloning of the mouse obese gene and its human homologue
Yiying Zhang,Ricardo Proenca,Ricardo Proenca,Margherita Maffei,Marisa Barone,Marisa Barone,Lori Leopold,Lori Leopold,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
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Leptin and the regulation of body weight in mammals
TL;DR: The role of leptin in the control of body weight and its relevance to the pathogenesis of obesity are reviewed.
Journal ArticleDOI
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
Eric S. Lander,Leonid Kruglyak +1 more
TL;DR: Specific standards designed to maintain rigor while also promoting communication are proposed for the interpretation of linkage results in genetic studies under way for many complex traits.