Journal ArticleDOI
The neuroendocrinology of obesity
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TLDR
As the nosology of obesity improves, diagnostic efficiency and therapeutic success should increase, leading to a decrease in associated morbidity, mortality, and socioeconomic ramifications.About:
This article is published in Endocrinology and Metabolism Clinics of North America.The article was published on 2001-09-01. It has received 59 citations till now. The article focuses on the topics: Birth weight & Weight loss.read more
Citations
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Journal ArticleDOI
Metabolism disrupting chemicals and metabolic disorders
Jerrold J. Heindel,Bruce Blumberg,Mathew C. Cave,Ronit Machtinger,Alberto Mantovani,Michelle A. Mendez,Angel Nadal,Paola Palanza,Giancarlo Panzica,Robert M. Sargis,Laura N. Vandenberg,Frederick S. vom Saal +11 more
TL;DR: This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders.
Journal ArticleDOI
Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice.
Kristen A. Lantz,Susan G. Emeigh Hart,Sonia Lobo Planey,Mitchell F. Roitman,Inez Ruiz-White,Henry R. Wolfe,Michael Mclane +6 more
TL;DR: The data establish trodusquemine as an effective central and peripheral PTP1B inhibitor with the potential to elicit noncachectic fat‐specific weight loss and improve insulin and leptin levels.
Journal ArticleDOI
Obesity and endocrine disease
TL;DR: The fat cell has been found to be an endocrine organ that produces several peptides that are bioactive and participate in the regulation of adipocyte function that contributes to the development of obesity.
Journal ArticleDOI
The Hypothalamic - Pituitary -Adrenal Axis in the Neuroendocrine Regulation of Food Intake and Obesity: The Role of Corticotropin Releasing Hormone
TL;DR: The role of the hypothalamic-pituitary-adrenal axis in the control of food intake and the pathogenesis of obesity is reviewed and the interactions between other neurosystems and this hormonal axis are discussed.
Journal ArticleDOI
A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion
Robert H. Lustig,Frank L. Greenway,Pedro Velasquez-Mieyer,D Heimburger,D Schumacher,Diane K. Smith,W Smith,N Soler,Ghulam Warsi,William Berg,J Maloney,John Benedetto,W. Zhu,John Hohneker +13 more
TL;DR: It is indicated that Caucasian patients with the greater degree of insulin hypersecretion appeared to derive the most benefit from treatment, and the observed safety profile was consistent with the known effects of octreotide from previous studies.
References
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Leptin levels in human and rodent : Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Margherita Maffei,Jeffrey L. Halaas,Eric Ravussin,Richard E. Pratley,Gwo-Hwa Lee,Gwo-Hwa Lee,Yan Zhang,Yan Zhang,Hong Fei,S. Kim,R. Lallone,S. Ranganathan,Philip A. Kern,Philip A. Kern,Jeffrey M. Friedman,Jeffrey M. Friedman +15 more
TL;DR: Weight loss due to food restriction was associated with a decrease in plasma leptin in samples from mice and obese humans, suggesting differences in its secretion rate from fat.
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Congenital leptin deficiency is associated with severe early-onset obesity in humans
C. T. Montague,I S Farooqi,Jonathan P. Whitehead,Maria A. Soos,Harald Rau,Nicholas J. Wareham,C. P. Sewter,JE Digby,S N Mohammed,J A Hurst,C H Cheetham,A R Earley,Anthony H. Barnett,Johannes B. Prins,Stephen O'Rahilly +14 more
TL;DR: The severe obesity found in two severely obese children who are members of the same highly consanguineous pedigree provides the first genetic evidence that leptin is an important regulator of energy balance in humans.
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Abnormal splicing of the leptin receptor in diabetic mice
Gwo-Hwa Lee,Gwo-Hwa Lee,Ricardo Proenca,Ricardo Proenca,Jason M. Montez,K. M. Carroll,J. G. Darvishzadeh,Jaeeon Lee,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: A leptin receptor was recently cloned from choroid plexus and shown to map to the same 6-cM interval on mouse chromosome 4 as db8, suggesting that the weight-reducing effects of leptin may be mediated by signal transduction through a leptin receptor in the hypothalamus.
Journal ArticleDOI
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Karine Clément,Christian Vaisse,Najiba Lahlou,Sylvie Cabrol,Véronique Pelloux,Dominique Cassuto,Micheline Gourmelen,Christian Dina,Jean Chambaz,Jean-Marc Lacorte,Arnaud Basdevant,Pierre Bougnères,Yves Lebouc,Philippe Froguel,Bernard Guy-Grand +14 more
TL;DR: A homozygous mutation in the human leptin receptor gene results in a truncated leptin receptor lacking both the transmembrane and the intracellular domains, which indicates that leptin is an important physiological regulator of several endocrine functions in humans.
Journal ArticleDOI
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard,Scott D. Feighner,Doris F. Cully,Joseph P. Arena,Paul A. Liberator,Charles Rosenblum,Michel J. Hamelin,Donna L. Hreniuk,Oksana C. Palyha,Jennifer W. Anderson,Philip S. Paress,Carmen Diaz,Michael Chou,Ken K. Liu,Karen K. McKee,Sheng-Shung Pong,Lee-Yuh Chaung,Alex Elbrecht,Mike Dashkevicz,Robert P. Heavens,Michael Rigby,Dalip J. S. Sirinathsinghji,Dennis C. Dean,David G. Melillo,Arthur A. Patchett,Ravi P. Nargund,Patrick R. Griffin,Julie A. DeMartino,Sunil Gupta,James M. Schaeffer,Roy G. Smith,Lex H.T. Van der Ploeg +31 more
TL;DR: A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.