Journal ArticleDOI
The NIMH Research Domain Criteria Initiative: Background, Issues, and Pragmatics.
TLDR
A number of theoretical and methodological issues that can arise in connection with the nature of RDoC constructs are highlighted: subjectivism and heterophenomenology, desynchrony and theoretical neutrality among units of analysis, theoretical reductionism, endophenotypes, biomarkers, neural circuits, construct "grain size," and analytic challenges.Abstract:
This article describes the National Institute of Mental Health's Research Domain Criteria (RDoC) initiative. The description includes background, rationale, goals, and the way the initiative has been developed and organized. The central RDoC concepts are summarized and the current matrix of constructs that have been vetted by workshops of extramural scientists is depicted. A number of theoretical and methodological issues that can arise in connection with the nature of RDoC constructs are highlighted: subjectivism and heterophenomenology, desynchrony and theoretical neutrality among units of analysis, theoretical reductionism, endophenotypes, biomarkers, neural circuits, construct “grain size,” and analytic challenges. The importance of linking RDoC constructs to psychiatric clinical problems is discussed. Some pragmatics of incorporating RDoC concepts into applications for NIMH research funding are considered, including sampling design.read more
Citations
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Journal ArticleDOI
Insomnia as a predictor of mental disorders: A systematic review and meta-analysis.
Elisabeth Hertenstein,Bernd Feige,Tabea Gmeiner,Christian Kienzler,Kai Spiegelhalder,Anna F. Johann,Markus Jansson-Fröjmark,Laura Palagini,Gerta Rücker,Dieter Riemann,Chiara Baglioni +10 more
TL;DR: This meta-analysis provides evidence that insomnia increases the risk for psychopathology and calls for more prospective long-term interventional studies investigating the efficacy of insomnia treatment for the prevention of mental disorders.
Journal ArticleDOI
The Lancet Psychiatry Commission on psychological treatments research in tomorrow's science
Emily A. Holmes,Ata Ghaderi,Catherine J. Harmer,Catherine J. Harmer,Paul Ramchandani,Pim Cuijpers,Anthony P. Morrison,Jonathan P. Roiser,Claudi L H Bockting,Rory C. O'Connor,Roz Shafran,Michelle L. Moulds,Michelle G. Craske +12 more
TL;DR: This Commission proposes opportunities to improve training in interdisciplinary mental health sciences, and outlines an area in which it sees substantial opportunity and scope for advancements that will move psychological treatments research forward.
Journal ArticleDOI
Identification of Common Neural Circuit Disruptions in Cognitive Control Across Psychiatric Disorders.
TL;DR: A common pattern of disruption across major psychiatric disorders that parallels the "multiple-demand network" observed in intact cognition is demonstrated, demonstrated to be transdiagnostically vulnerable to gray matter reduction.
Journal ArticleDOI
Treatment resistant depression: A multi-scale, systems biology approach.
Huda Akil,Joshua A. Gordon,René Hen,Jonathan A. Javitch,Helen S. Mayberg,Bruce S. McEwen,Michael J. Meaney,Eric J. Nestler +7 more
TL;DR: A multi‐scale framework for fundamental research on depression is proposed, aimed at identifying the brain circuits that are dysfunctional in several animal models of depression as well the changes in gene expression that are associated with these models.
Journal ArticleDOI
Transdiagnostic impairment of cognitive control in mental illness
TL;DR: Transdiagnostic patterns of symptomatic distress and neurocognitive performance deficits, concurrent with parallel anomalies of brain structure and function may largely contribute to the real-world socio-occupational impairment common across disorders.
References
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