Journal ArticleDOI
The promise of N-acetylcysteine in neuropsychiatry.
Michael Berk,Gin S Malhi,Gin S Malhi,Laura J. Gray,Olivia M Dean,Olivia M Dean,Olivia M Dean +6 more
TLDR
The efficacy pattern of NAC interestingly shows little respect for the current diagnostic systems, and its benign tolerability profile, its action on multiple operative pathways, and the emergence of positive trial data make it one of the most promising drug candidates in neuropsychiatric disorders.About:
This article is published in Trends in Pharmacological Sciences.The article was published on 2013-03-01. It has received 372 citations till now. The article focuses on the topics: Schizophrenia.read more
Citations
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Journal ArticleDOI
The chemistry and biological activities of N-acetylcysteine
TL;DR: The present review is focused on the chemistry of NAC and its interactions and functions at the organ, tissue and cellular levels in an attempt to bridge the gap between its recognized biological activities and chemistry.
Journal ArticleDOI
The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
TL;DR: The ventral subiculum and lateral hypothalamus are highlighted as emerging brain areas important for reinstatement of drug seeking across drug classes and the existence of differences in brain mechanisms controlling reinstatement in drug seeking is highlighted.
Journal ArticleDOI
Altering the course of schizophrenia: progress and perspectives
Millan Mark,Annie Andrieux,George Bartzokis,Kristin S. Cadenhead,Paola Dazzan,Paolo Fusar-Poli,Jürgen Gallinat,Jay N. Giedd,Dennis R. Grayson,Markus Heinrichs,René S. Kahn,Marie-Odile Krebs,Marion Leboyer,David A. Lewis,Oscar Marín,Philippe Marin,Andreas Meyer-Lindenberg,Patrick D. McGorry,Philip McGuire,Michael John Owen,Paul Patterson,Akira Sawa,Michael Spedding,Peter J. Uhlhaas,Flora M. Vaccarino,Claes Wahlestedt,Daniel R. Weinberger +26 more
TL;DR: A broad-based consideration of the challenges and opportunities inherent in efforts to alter the course of schizophrenia is provided, including 'hybrid' strategies that both relieve presenting symptoms and reduce the risk of transition to schizophrenia or another psychiatric disorder.
Journal ArticleDOI
Nutritional medicine as mainstream in psychiatry.
Jerome Sarris,Jerome Sarris,Alan C. Logan,Tasnime N. Akbaraly,Tasnime N. Akbaraly,G. Paul Amminger,Vicent Balanzá-Martínez,Marlene P. Freeman,Joseph R. Hibbeln,Yutaka Matsuoka,David Mischoulon,Tetsuya Mizoue,Akiko Nanri,Daisuke Nishi,Drew Ramsey,Julia J. Rucklidge,Almudena Sánchez-Villegas,Andrew Scholey,Kuan-Pin Su,Felice N. Jacka +19 more
TL;DR: A viewpoint from an international collaboration of academics is presented, in which a context and overview of the current evidence in this emerging field of research is provided, and the future direction of recognition of diet and nutrition as central determinants of both physical and mental health is advocated.
Journal ArticleDOI
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review
Deepmala,Deepmala,John Slattery,Nihit Kumar,Leanna Delhey,Michael Berk,Olivia M Dean,Charles Spielholz,Richard E. Frye +8 more
TL;DR: In this article, the authors found favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy.
References
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TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Neurocircuitry of Addiction
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A Meta-Analysis of Cytokines in Major Depression
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Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
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