The relationship between hepatic resistin overexpression and inflammation in patients with nonalcoholic steatohepatitis
Chuan Shen,Caiyan Zhao,Wei Wang,Yadong Wang,Hui Sun,Wei Cao,Weiyan Yu,Li Zhang,R u Ji,Meng Li,Jian Gao +10 more
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TLDR
Hepatic resistin overexpression in NASH patients is associated with the severity of liver inflammation and fibrosis, and Liver-derived resistin may be involved in the pathogenesis of human NASH.Abstract:
Background
The relationship between resistin and non-alcoholic steatohepatitis (NASH) is not clear, some studies claimed that serum resistin levels were associated with neither the presence of NASH nor its severity, others declared that serum resistin was related with inflammation and fibrosis in NASH. Our animal study verified that the distribution of resistin in the liver is correlated with inflammation in NASH. However, there is no pertinent study in humans.read more
Citations
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Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
Ana L. Cardoso,Adelaide Fernandes,Juan Antonio Aguilar-Pimentel,Martin Hrabé de Angelis,Joana R. Guedes,Maria Alexandra Brito,Saida Ortolano,Giovambattista Pani,Sophia Athanasopoulou,Efstathios S. Gonos,Markus Schosserer,Johannes Grillari,Pärt Peterson,Bilge Guvenc Tuna,Soner Dogan,Angelika Meyer,Ronald van Os,Anne-Ulrike Trendelenburg +17 more
TL;DR: Biomarker panels for frailty would be of high value and better than single markers.
Journal ArticleDOI
Adipokines in nonalcoholic fatty liver disease.
TL;DR: Evidence on the association between adipokines and nonalcoholic fatty liver disease (NAFLD) is summarized: leptin levels increase, whereas adiponectin levels decrease, by increasing the severity of NAFLD.
Journal Article
Serum resistin (FIZZ3) protein is increased in obese humans. Authors' reply
J. V. Silha,Liam J. Murphy,Mikako Degawa-Yamauchi,Jason E. Bovenkerk,Beth Elisa,William R. Watson,Kimberly A Kerr,RoseMarie Jones,Robert V. Considine +8 more
TL;DR: It is demonstrated that resistin protein is present in human adipose tissue and blood, and that there is significantly more resistin in the serum of obese subjects, than lean subjects and that Serum resistin is not a significant predictor of insulin resistance in humans.
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Metabolic aspects of adult patients with nonalcoholic fatty liver disease
Ludovico Abenavoli,Natasa Milic,Laura Di Renzo,Tomislav Preveden,Milica Medic-Stojanoska,Antonino De Lorenzo +5 more
TL;DR: The present review analyses the current literature and highlights the new evidence on the metabolic aspects in the adult patients with NAFLD.
Journal ArticleDOI
Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease.
TL;DR: Possible therapeutic implications targeting the modulation of adipokine levels as a potential tool for the treatment of NAFLD are discussed, which may contribute to the improvement of liver function.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions
Elizabeth M. Brunt,Christine G. Janney,Adrian M. Di Bisceglie,Brent A. Neuschwander-Tetri,Bruce R. Bacon +4 more
TL;DR: There are no systems for grading necroinflammatory activity or for staging fibrosis as exist for various other forms of chronic liver disease and this study proposes a grading and staging system that reflects the unique histological features of nonalcoholic steatohepatitis.
Journal ArticleDOI
Nonalcoholic fatty liver disease: From steatosis to cirrhosis
TL;DR: The present “gold standard” management of NASH is modest weight reduction, particularly correction of central obesity achieved by combining dietary measures with increased physical activity, which improves insulin resistance and reverses steatosis, hepatocellular injury, inflammation, and fibrosis.
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Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma
Elisabetta Bugianesi,Nicola Leone,Ester Vanni,Giulio Marchesini,Franco Brunello,Patrizia Carucci,Alessandro Musso,Paolo De Paolis,Lorenzo Capussotti,Mauro Salizzoni,Mario Rizzetto +10 more
TL;DR: Features suggestive of NASH are more frequently observed in HCC arising in patients with CC than in age- and sex-matched HCC patients of well-defined viral or alcoholic etiology.
Journal ArticleDOI
Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study†‡
Giorgio Bedogni,L. Miglioli,Flora Masutti,Claudio Tiribelli,Giulio Marchesini,Stefano Bellentani +5 more
TL;DR: NAFLD is highly prevalent in the general population, is not associated with SLD, but is associated with many features of the metabolic syndrome.