Journal ArticleDOI
The SLC22 family with transporters of organic cations, anions and zwitterions.
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TLDR
It has been shown that mutations of the SLC22 genes encoding these transporters cause specific diseases like primary systemic carnitine deficiency and idiopathic renal hypouricemia and are correlated with diseases such as Crohn's disease and gout.About:
This article is published in Molecular Aspects of Medicine.The article was published on 2013-04-01. It has received 343 citations till now. The article focuses on the topics: Organic cation transport proteins & Cotransporter.read more
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Journal ArticleDOI
What do drug transporters really do
TL;DR: Evidence is discussed for the roles of ABC and SLC transporters in the handling of diverse substrates, including metabolites, antioxidants, signalling molecules, hormones, nutrients and neurotransmitters, which may help to clarify disease mechanisms, drug–metabolite interactions and drug effects relevant to diabetes, chronic kidney disease, metabolic syndrome, hypertension, gout, liver disease, neuropsychiatric disorders, inflammatory syndromes and organ injury.
Journal ArticleDOI
Structural Biology of the Major Facilitator Superfamily Transporters.
TL;DR: The history, classification, and general features of the MFS proteins are reviewed; recent structural progress is summarized with a focus on the sugar porter family transporters exemplified by GLUT1; and the molecular mechanisms of substrate binding, alternating access, and cotransport coupling are discussed.
Journal ArticleDOI
The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective
Sanjay K. Nigam,Kevin T. Bush,Gleb Martovetsky,Sun-Young Ahn,Henry C. Liu,Erin Richard,Vibha Bhatnagar,Wei Wu +7 more
TL;DR: According to the "Remote Sensing and Signaling Hypothesis," which is elaborated in detail here, Oats may function in remote interorgan communication by regulating levels of signaling molecules and key metabolites in tissues and body fluids.
Journal ArticleDOI
Understanding transport by the major facilitator superfamily (MFS): structures pave the way
TL;DR: An updated model for the conformational cycle of MFS transporters, the 'clamp-and-switch model', is proposed and the role of so-called 'gating residues' and the substrate in modulating these conformational changes are discussed.
Journal ArticleDOI
The Regulation of Steroid Action by Sulfation and Desulfation
TL;DR: The interplay between sulfatases and sulfotransferases is described, showing how their expression and regulation influences steroid action, and the role that organic anion-transporting polypeptides play in regulating intracellular steroid concentrations is addressed.
References
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Journal ArticleDOI
Molecular identification of a renal urate anion exchanger that regulates blood urate levels.
Atsushi Enomoto,Hiroaki Kimura,Hiroaki Kimura,Arthit Chairoungdua,Yasuhiro Shigeta,Yasuhiro Shigeta,Promsuk Jutabha,Seok Ho Cha,Makoto Hosoyamada,Michio Takeda,Takashi Sekine,Takashi Igarashi,Hirotaka Matsuo,Hirotaka Matsuo,Yuichi Kikuchi,Takashi Oda,Kimiyoshi Ichida,Tatsuo Hosoya,Kaoru Shimokata,Toshimitsu Niwa,Yoshikatsu Kanai,Hitoshi Endou +21 more
TL;DR: This work identifies the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate–anion exchanger regulating blood urate levels and targeted by uricosuric and antiuricOSuric agents (which affect excretion of uric acid).
Journal ArticleDOI
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Meredith Yeager,Nick Orr,Richard B. Hayes,Kevin B. Jacobs,Peter Kraft,Sholom Wacholder,Mark J Minichiello,Paul Fearnhead,Kai Yu,Nilanjan Chatterjee,Zhaoming Wang,Zhaoming Wang,Robert W Welch,Robert W Welch,Brian Staats,Brian Staats,Eugenia E. Calle,Heather Spencer Feigelson,Michael J. Thun,Carmen Rodriguez,Demetrius Albanes,Jarmo Virtamo,Stephanie J. Weinstein,Fredrick R. Schumacher,Edward Giovannucci,Walter C. Willett,Geraldine Cancel-Tassin,Olivier Cussenot,Antoine Valeri,Gerald L. Andriole,Edward P. Gelmann,Margaret A. Tucker,Daniela S. Gerhard,Joseph F. Fraumeni,Robert N. Hoover,David J. Hunter,David J. Hunter,Stephen J. Chanock,Gilles Thomas +38 more
TL;DR: Observations indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry, and it is estimated that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked byrs1447295.
Journal ArticleDOI
Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications.
TL;DR: Transport studies with expressed OCTs will help to optimize pharmacokinetics during development of new drugs, and the recent identification of polymorphisms in human OCTs and OCTNs allows the identification of patients with an increased risk for adverse drug reactions.
Journal ArticleDOI
Integrative molecular concept modeling of prostate cancer progression
Scott A. Tomlins,Rohit Mehra,Daniel R. Rhodes,Xuhong Cao,Lei Wang,Saravana M. Dhanasekaran,Shanker Kalyana-Sundaram,John T. Wei,Mark A. Rubin,Kenneth J. Pienta,Rajal B. Shah,Arul M. Chinnaiyan +11 more
TL;DR: Using laser-capture microdissection to isolate 101 cell populations, an integrative model of prostate cancer progression from benign epithelium to metastatic disease is generated and shows that analyzing gene expression signatures in the context of a compendium of molecular concepts is useful in understanding cancer biology.
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