Citations
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Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
Jakob Lovén,Heather A. Hoke,Charles Y. Lin,Charles Y. Lin,Ashley Lau,David A. Orlando,Christopher R. Vakoc,James E. Bradner,Tong Ihn Lee,Richard A. Young +9 more
TL;DR: This work investigates how inhibition of the widely expressed transcriptional coactivator BRD4 leads to selective inhibition ofThe MYC oncogene in multiple myeloma (MM), and finds that super-enhancers were found at key oncogenic drivers in many other tumor cells.
Journal ArticleDOI
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
TL;DR: Well known for its role in tumour cell proliferation, survival, invasion and immunosuppression, JAK–STAT3 signalling also promotes cancer through inflammation, obesity, stem cells and the pre-metastatic niche.
Journal ArticleDOI
A Validated Regulatory Network for Th17 Cell Specification
Maria Ciofani,Aviv Madar,Aviv Madar,Carolina Galan,MacLean Sellars,Kieran Mace,Florencia Pauli,Ashish Agarwal,Wendy Huang,Christopher N. Parkurst,Michael Muratet,Kim M. Newberry,Sarah Meadows,Alex Greenfield,Yi Yang,Preti Jain,Francis K. Kirigin,Carmen Birchmeier,Erwin F. Wagner,Kenneth M. Murphy,Kenneth M. Murphy,Richard M. Myers,Richard Bonneau,Richard Bonneau,Dan R. Littman,Dan R. Littman +25 more
TL;DR: It is found that cooperatively bound BATF and IRF4 contribute to initial chromatin accessibility and, with STAT3, initiate a transcriptional program that is then globally tuned by the lineage-specifying TF RORγt, which plays a focal deterministic role at key loci.
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Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma
Krishna P.L. Bhat,Veerakumar Balasubramaniyan,Brian Vaillant,Ravesanker Ezhilarasan,Karlijn Hummelink,Faith Hollingsworth,Khalida Wani,Lindsey Heathcock,Johanna D. James,Lindsey D. Goodman,Siobhan Conroy,Lihong Long,Nina Lelic,Suzhen Wang,Joy Gumin,Divya Raj,Yoshinori Kodama,Aditya Raghunathan,Adriana Olar,Kaushal Joshi,Christopher E. Pelloski,Amy B. Heimberger,Se Hoon Kim,Daniel P. Cahill,Ganesh Rao,Wilfred F. A. den Dunnen,Hendrikus Boddeke,Heidi S. Phillips,Ichiro Nakano,Frederick F. Lang,Howard Colman,Erik P. Sulman,Kenneth Aldape +32 more
TL;DR: It is shown that patient-derived glioma sphere cultures that resemble either the proneural (PN) or mesenchymal (MES) transcriptomal subtypes differ significantly in their biological characteristics, and it is suggested that the tumor microenvironment cell types such as macrophages/microglia may play an integral role in this process.
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On the Origin of Cancer Metastasis
TL;DR: The view of metastatic cancer cells as a macrophage metabolic disease can provide novel insight for therapeutic management and explain the long-standing "seed and soil" hypothesis and the absence of metastasis in plant cancers.
References
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Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
Heidi S. Phillips,Samir Kharbanda,Ruihuan Chen,William F. Forrest,Robert Soriano,Thomas D. Wu,Anjan Misra,Janice Nigro,Howard Colman,Liliana Soroceanu,P. Mickey Williams,Zora Modrusan,Burt G. Feuerstein,Kenneth Aldape +13 more
TL;DR: Previously undescribed prognostic subclasses of high-grade astrocytoma are identified and discovered to resemble stages in neurogenesis, suggesting functional relevance of tumor subtype molecular signatures is suggested by the ability of cell line signatures to predict neurosphere growth.
Journal ArticleDOI
The transcriptional network for mesenchymal transformation of brain tumours
Maria Stella Carro,Wei Keat Lim,Mariano J. Alvarez,Robert J. Bollo,Xudong Zhao,Evan Y. Snyder,Erik P. Sulman,Sandrine L. Anne,Sandrine L. Anne,Fiona Doetsch,Howard Colman,Anna Lasorella,Kenneth Aldape,Andrea Califano,Antonio Iavarone +14 more
TL;DR: It is shown that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignantglioma.