Journal ArticleDOI
Thyrotrophin in the pars tuberalis triggers photoperiodic response
Nobuhiro Nakao,Hiroko Ono,Takashi Yamamura,Tsubasa Anraku,Tsuyoshi Takagi,Kumiko Higashi,Shinobu Yasuo,Yasuhiro Katou,Saburo Kageyama,Yumiko Uno,Takeya Kasukawa,Masayuki Iigo,Peter J. Sharp,Atsushi Iwasawa,Yutaka Suzuki,Sumio Sugano,Teruyuki Niimi,Makoto Mizutani,Takao Namikawa,Shizufumi Ebihara,Hiroki R. Ueda,Takashi Yoshimura +21 more
Reads0
Chats0
TLDR
Two waves of gene expression are identified in the quail MBH associated with the initiation of photoinduced secretion of luteinizing hormone and increased TSH in the pars tuberalis seems to trigger long-day photoinduced seasonal breeding.Abstract:
Molecular mechanisms regulating animal seasonal breeding in response to changing photoperiod are not well understood. Rapid induction of gene expression of thyroid-hormone-activating enzyme (type 2 deiodinase, DIO2) in the mediobasal hypothalamus (MBH) of the Japanese quail (Coturnix japonica) is the earliest event yet recorded in the photoperiodic signal transduction pathway. Here we show cascades of gene expression in the quail MBH associated with the initiation of photoinduced secretion of luteinizing hormone. We identified two waves of gene expression. The first was initiated about 14 h after dawn of the first long day and included increased thyrotrophin (TSH) beta-subunit expression in the pars tuberalis; the second occurred approximately 4 h later and included increased expression of DIO2. Intracerebroventricular (ICV) administration of TSH to short-day quail stimulated gonadal growth and expression of DIO2 which was shown to be mediated through a TSH receptor-cyclic AMP (cAMP) signalling pathway. Increased TSH in the pars tuberalis therefore seems to trigger long-day photoinduced seasonal breeding.read more
Citations
More filters
Journal ArticleDOI
RFamide-related peptide and its cognate receptor in the sheep: cDNA cloning, mRNA distribution in the hypothalamus and the effect of photoperiod.
TL;DR: Interestingly, RFRP expression in the ependymal cells surrounding the base of the third ventricle was highly photoperiodic, with levels being undetectable in animals held on SP but consistently high under LP, which is inconsistent with a conserved reproductive role for R FRP across mammals.
Book ChapterDOI
Seasonal Regulation of Reproduction in Mammals
TL;DR: This chapter first discusses the ecological context for seasonal breeding and the pivotal role that nocturnal melatonin secretion plays in its regulation, and discusses the emergence of the pars tuberalis of the anterior pituitary as a principal site of melatonin action.
Journal ArticleDOI
Clocks for all seasons: unwinding the roles and mechanisms of circadian and interval timers in the hypothalamus and pituitary
TL;DR: In this paper, the pars tuberalis (PT) of the pituitary gland plays an essential role in seasonal change in thyroid hormone (TH) availability within the brain, mediated by local control of TH-metabolising enzymes within specialised ependymal cells lining the third ventricle of the hypothalamus.
Thyroid Hormones in Brain Development and Function
TL;DR: The sydromes of Resistance to Thyroid Hormones due to receptor mutations, especially TRα, cause variable affectation of brain function and a deep understanding of the pathophysiology of these syndromes is needed to allow designing appropriate therapies.
Journal ArticleDOI
Selection Signatures in Worldwide Sheep Populations
María Inés Fariello,Bertrand Servin,Gwenola Tosser-Klopp,Rachel Rupp,Carole Moreno,Magali San Cristobal,Simon Boitard +6 more
TL;DR: The newly identified regions of selection signatures in worldwide sheep populations reveal the extensive genome response to selection on morphology, color and adaptation to new environments.
References
More filters
Journal ArticleDOI
Coordinated transcription of key pathways in the mouse by the circadian clock.
Satchidananda Panda,Marina P. Antoch,Brooke H. Miller,Andrew I. Su,Andrew I. Su,Andrew B. Schook,Marty Straume,Peter G. Schultz,Peter G. Schultz,Steve A. Kay,Steve A. Kay,Joseph S. Takahashi,John B. Hogenesch +12 more
TL;DR: Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components, and major processes regulated by the SCN and liver were found to be under circadian regulation.
Journal ArticleDOI
Photoperiodic Control of Seasonality in Birds
TL;DR: This review examines how birds use the annual cycle in photoperiod to ensure that seasonal events—breeding, molt, and song production—happen at the appropriate time of year.
Journal ArticleDOI
A transcription factor response element for gene expression during circadian night
Hiroki R. Ueda,Wenbin Chen,Akihito Adachi,Hisanori Wakamatsu,Satoko Hayashi,Tomohiro Takasugi,Mamoru Nagano,Ken-ichi Nakahama,Yutaka Suzuki,Sumio Sugano,Masamitsu Iino,Yasufumi Shigeyoshi,Seiichi Hashimoto +12 more
TL;DR: The role of the Rev-ErbA/ROR response element in gene expression during circadian night is demonstrated, which is in phase with Bmal1 and in antiphase to Per2 oscillations.
Journal ArticleDOI
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
K Maruyama,Sumio Sugano +1 more
TL;DR: Unlike the conventional methods that label the 5' end of cDNAs, this method specifically labels the capped end of the mRNAs with a synthetic r-oligo prior to first-strand cDNA synthesis.
Journal ArticleDOI
Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity
TL;DR: The results reveal that signaling-dependent activation of mPer genes is distinct from the CLOCK/BMAL1-driven transcription required within the clock feedback loop, and constitute strong evidence that CREB acts as a pivotal endpoint of signaling pathways for the regulation of m per genes.