Transgene-free remote magnetothermal regulation of adrenal hormones
Dekel Rosenfeld,Alexander W. Senko,Junsang Moon,Isabel Yick,Georgios Varnavides,Georgios Varnavides,Danijela Gregurec,Florian Koehler,Po Han Chiang,Michael G. Christiansen,Lisa Y. Maeng,Alik S. Widge,Polina Anikeeva +12 more
Reads0
Chats0
TLDR
This work demonstrates an alternative strategy for modulating peripheral organ function, which relies on the endogenous expression of a heat-sensitive cation channel, transient receptor potential vanilloid family member 1 (TRPV1), and heat dissipation by magnetic nanoparticles (MNPs) in remotely applied alternating magnetic fields to wirelessly control adrenal hormone secretion in genetically intact rats.Abstract:
The field of bioelectronic medicines seeks to modulate electrical signaling within peripheral organs, providing temporally precise control of physiological functions. This is usually accomplished with implantable devices, which are often unsuitable for interfacing with soft and highly vascularized organs. Here, we demonstrate an alternative strategy for modulating peripheral organ function, which relies on the endogenous expression of a heat-sensitive cation channel, transient receptor potential vanilloid family member 1 (TRPV1), and heat dissipation by magnetic nanoparticles (MNPs) in remotely applied alternating magnetic fields. We use this approach to wirelessly control adrenal hormone secretion in genetically intact rats. TRPV1-dependent calcium influx into the cells of adrenal cortex and medulla is sufficient to drive rapid release of corticosterone and (nor)epinephrine. As altered levels of these hormones have been correlated with mental conditions such as posttraumatic stress disorder and major depression, our approach may facilitate the investigation of physiological and psychological impacts of stress.read more
Citations
More filters
Introduction To Electrodynamics
TL;DR: The introduction to electrodynamics is universally compatible with any devices to read and is available in the book collection an online access to it is set as public so you can get it instantly.
Journal ArticleDOI
Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling
Junsang Moon,Junsang Moon,Michael G. Christiansen,Siyuan Rao,Siyuan Rao,Colin Marcus,David Bono,Dekel Rosenfeld,Dekel Rosenfeld,Danijela Gregurec,Danijela Gregurec,Georgios Varnavides,Georgios Varnavides,Po Han Chiang,Po Han Chiang,Po Han Chiang,Seongjun Park,Polina Anikeeva +17 more
Journal ArticleDOI
Magnetothermal nanoparticle technology alleviates parkinsonian-like symptoms in mice.
Sarah Hescham,Po Han Chiang,Danijela Gregurec,Danijela Gregurec,Junsang Moon,Michael G. Christiansen,Ali Jahanshahi,Huajie Liu,Dekel Rosenfeld,Arnd Pralle,Polina Anikeeva,Yasin Temel +11 more
TL;DR: In this article, a wireless magnetothermal approach to DBS (mDBS) was demonstrated to provide similar therapeutic benefits in two mouse models of Parkinson's disease, the bilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and in the unilateral 6-hydroxydopamine (6-OHDA) model.
Journal ArticleDOI
Emerging Frontier of Peripheral Nerve and Organ Interfaces.
TL;DR: The innovations in bioelectronics borne out of interdisciplinary collaborations between biologists and physical scientists may not only advance fundamental study of peripheral physiology but also empower clinical interventions for conditions including neurological, gastrointestinal, and immune dysfunction.
Journal ArticleDOI
Magnetothermal regulation of in vivo protein corona formation on magnetic nanoparticles for improved cancer nanotherapy.
Tingbin Zhang,Galong Li,Yuqing Miao,Junjie Lu,Ningqiang Gong,Yifan Zhang,Yuantai Sun,Yuan He,Mingli Peng,Xiaoli Liu,Xing-Jie Liang,Haiming Fan +11 more
TL;DR: In this article, the protein corona (PC) on nanodrugs is tuned quantitatively by means of heat induction mediated by the nanoparticles under an alternating magnetic field.
References
More filters
Journal ArticleDOI
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Michael J. Caterina,Mark Schumacher,Makoto Tominaga,Tobias A. Rosen,Jon D. Levine,David Julius +5 more
TL;DR: The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
Journal ArticleDOI
How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
Journal ArticleDOI
TOPICAL REVIEW: Applications of magnetic nanoparticles in biomedicine
Book ChapterDOI
Applications of magnetic nanoparticles in biomedicine
TL;DR: The physical principles underlying some current biomedical applications of magnetic nanoparticles are reviewed and the relevant physics of magnetic materials and their responses to applied magnetic fields are surveyed.
Journal ArticleDOI
Optogenetics in neural systems.
TL;DR: A primer on the application of optogenetics in neuroscience is provided, focusing on the single-component tools and highlighting important problems, challenges, and technical considerations.