Transplantation of Mesenchymal Stromal Cells in Patients With Amyotrophic Lateral Sclerosis: Results of Phase I/IIa Clinical Trial.
Eva Syková,Eva Syková,Petr Rychmach,Ivana Drahorádová,Šimona Konrádová,Kateřina Růžičková,Ivan Vořišek,Serhiy Forostyak,Serhiy Forostyak,Aleš Homola,Martin Bojar +10 more
TLDR
The results demonstrate that the intrathecal application of BM-MSCs in ALS patients is a safe procedure and that it can slow down progression of the disease.About:
This article is published in Cell Transplantation.The article was published on 2017-04-01 and is currently open access. It has received 118 citations till now. The article focuses on the topics: Amyotrophic lateral sclerosis & Transplantation.read more
Citations
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Journal ArticleDOI
Mesenchymal Stem Cells for Regenerative Medicine.
TL;DR: A brief overview of MSC extraction methods and subsequent potential for differentiation is presented, and a comprehensive overview of their preclinical and clinical applications in regenerative medicine is presented.
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Challenges and Controversies in Human Mesenchymal Stem Cell Therapy.
Barbara Lukomska,Luiza Stanaszek,Ewa K. Zuba-Surma,Pawel Legosz,Sylwia Sarzyńska,Katarzyna Drela +5 more
TL;DR: The complex nature of MSCs is critically discussed in the context of their effective and safe applications in regenerative medicine in different diseases including graft versus host disease (GvHD) and cardiac, neurological, and orthopedic disorders.
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Regenerative Capacity of Adipose Derived Stem Cells (ADSCs), Comparison with Mesenchymal Stem Cells (MSCs).
TL;DR: This review analyzed the therapeutic advancement of ADSCs in comparison to bone marrow (BM) and umbilical cord (UC)-mesenchymal stem cells (MSCs) and designed the specific requirements to their best clinical practices and safety.
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Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications
TL;DR: The pharmacological therapies for ALS that target neuroinflammation, as well as recent advances in the field of stem cell therapy aimed at modulating the inflammatory environment to preserve the remaining MNs in ALS patients and animal models of the disease are summarized.
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Mesenchymal Stromal Cell Therapeutic Delivery: Translational Challenges to Clinical Application
Henry W. Caplan,Scott D. Olson,Akshita Kumar,Mitchell J. George,Karthik S. Prabhakara,Pamela L. Wenzel,Supinder S. Bedi,Naama E. Toledano-Furman,Fabio Triolo,Julian Kamhieh-Milz,Guido Moll,Charles S. Cox +11 more
TL;DR: Novel topics critical to the successful translation of MSCs from pre-clinical to clinical applications are discussed, including the major routes of cell delivery, aspects related to hemocompatibility, and potential safety concerns associated with MSC therapy in the different settings.
References
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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
TL;DR: Tight genetic linkage between FALS and a gene that encodes a cytosolic, Cu/Zn-binding superoxide dismutase (SOD1), a homodimeric metalloenzyme that catalyzes the dismutation of the toxic superoxide anion O–2 to O2 and H2O2 is reported.
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El Escorial revisited : revised criteria for the diagnosis of amyotrophic lateral sclerosis
TL;DR: The criteria described below represent the result of a three-day workshop, convened at Airlie Conference Center, Warrenton, Virginia on 2–4 April, 1998 by the World Federation of Neurology Research Committee on Motor Neuron Diseases, and are placed on the WFN ALS website.
Journal ArticleDOI
Mesenchymal stem cells in health and disease
TL;DR: The targets and mechanisms of M SC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches are discussed.
Journal ArticleDOI
Mesenchymal stem cells as trophic mediators.
Arnold I. Caplan,James E. Dennis +1 more
TL;DR: Several studies which tested the use of MSCs in models of infarct (injured heart), stroke (brain), or meniscus regeneration models are reviewed within the context of M SC‐mediated trophic effects in tissue repair.
Journal ArticleDOI
Human marrow stromal cell therapy for stroke in rat Neurotrophins and functional recovery
Yi Li,Jieli Chen,X. G. Chen,L. Wang,Subhash C. Gautam,Y.X. Xu,Mark Katakowski,Lijie Zhang,Mei Lu,N. Janakiraman,Michael Chopp +10 more
TL;DR: Neurologic benefit resulting from hMSC treatment of stroke in rats may derive from the increase of growth factors in the ischemic tissue, the reduction of apoptosis in the penumbral zone of the lesion, and the proliferation of endogenous cells in the subventricular zone.
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Letizia Mazzini,Ivana Ferrero,Ivana Ferrero,V. Luparello,Deborah Rustichelli,Monica Gunetti,Katia Mareschi,Katia Mareschi,Lucia Testa,Alessandro Stecco,R. Tarletti,Massimo Miglioretti,E. Fava,N. Nasuelli,Carlo Cisari,Maurilio Massara,R. Vercelli,G.D. Oggioni,Alessandro Carriero,Roberto Cantello,Francesco Monaco,Franca Fagioli +21 more