Open AccessJournal Article
Transport and metabolism of vitamin A
TLDR
Findings on vitamin A transport from intestines to target-cell and metabolism of this fat-soluble vitamin are reviewed and possible roles of cellular retinoid-binding proteins in the process of Vitamin A transport and metabolism are reviewed.Abstract:
The present paper is a review of up-to-date findings on vitamin A transport from intestines to target-cell and metabolism of this fat-soluble vitamin. The hypotheses of possible enzymes participation in the process of etherification/hydrolysis and oxidation/reduction of vitamin A are discussed. Furthermore, possible roles of cellular retinoid-binding proteins in the process of vitamin A transport and metabolism are reviewed.read more
Citations
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Dietary Carotenoids and Vitamins A, C, and E and Risk of Breast Cancer
Shumin M. Zhang,David J. Hunter,Michele R. Forman,Bernard Rosner,Frank E. Speizer,Graham A. Colditz,JoAnn E. Manson,Susan E. Hankinson,Walter C. Willett +8 more
TL;DR: Consumption of fruits and vegetables high in specific carotenoids and vitamins may reduce premenopausal breast cancer risk.
Journal ArticleDOI
International Union of Pharmacology. LX. Retinoic Acid Receptors
Pierre Germain,Pierre Germain,Pierre Chambon,Gregor Eichele,Ronald M. Evans,Mitchell A. Lazar,Mark Leid,Angel R. de Lera,Reuben Lotan,David J. Mangelsdorf,Hinrich Gronemeyer +10 more
TL;DR: This review summarizes the considerable amount of knowledge generated on retinoids, members of the nuclear hormone receptor superfamily, which regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders.
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Vitamins A and E: metabolism, roles and transfer to offspring.
Cathy Debier,Yvan Larondelle +1 more
TL;DR: An overview of their biological functions, metabolism and dynamics of transfer to offspring in mammals, including the biochemical aspects of their intestinal absorption, blood transport, tissue uptake, storage and catabolism is presented.
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Modulation of T Cell and Innate Immune Responses by Retinoic Acid
TL;DR: Retinoic acid plays a role in immune homeostasis in the steady-state but activates pathogenic T cells in conditions of inflammation.
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The vitamin A-redox hypothesis: a biochemical basis for honest signaling via carotenoid pigmentation.
TL;DR: The vitamin A–redox hypothesis is presented as a testable alternative hypothesis to the resource trade-off hypothesis for the maintenance of honesty of carotenoid pigmentation.
References
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Journal ArticleDOI
Tissue expression of retinoic acid receptor alpha and CRABP2 in metastatic nephroblastomas.
Ana Paula Percicote,Gabriel Lazaretti Mardegan,Elizabeth Schneider Gugelmim,Sérgio Ossamu Ioshii,Ana Paula Kuczynski,Seigo Nagashima,Lucia de Noronha +6 more
TL;DR: Semiquantitative and quantitative analyses of the markers RARA and CRABP2 indicate their potential as biomarkers for tumor progression and their participation in nephroblastoma tumorigenesis.
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Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia
Helman Alfonso,Alison Reid,Nicholas de Klerk,Nola Olsen,R. Mina,Gina L. Ambrosini,John Beilby,Geoffrey Berry,Bill Musk +8 more
TL;DR: This study provides little support for possible preventive effects of retinol against mesothelioma in workers exposed to blue asbestos.
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The potential double-burden of vitamin A malnutrition: under- and overconsumption of fortified table Sugar in the Guatemalan highlands
TL;DR: The vitamin A contribution from fortified sugar can be a determinant of reaching adequacy; nevertheless, a significant proportion of pregnant and lactating women do not meet the EAR, especially in the rural setting.
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Transient expression of cellular retinol-binding protein-1 during cardiac repair after myocardial infarction
Mengyue Yu,Hatsue Ishibashi-Ueda,Keiko Ohta-Ogo,Giulio Gabbiani,Masakazu Yamagishi,Kenshi Hayashi,Seiichi Hirota,Marie-Luce Bochaton-Piallat,Hiroyuki Hao +8 more
TL;DR: Human heart specimens of individuals with a recent myocardial infarction demonstrated presence of CRBP‐1‐positive fibroblasts by immunohistochemistry, suggesting that CR BP‐1 plays a role in ventricular remodeling after MI allegedly through its RA binding activity.
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Retinoid concentrations in the mouse during postnatal development and after maternal vitamin A supplementation
TL;DR: The results show for the first time that supplementation with high doses of VA during the lactation period in mice can affect serum retinol concentrations in the neonates and report that day 7 after birth is a critical time in the tissue distribution of retinoids during postnatal development.