Journal ArticleDOI
Tyrosine phosphatases as key regulators of StAR induction and cholesterol transport: SHP2 as a potential tyrosine phosphatase involved in steroid synthesis.
Mariana Cooke,Pablo G. Mele,Paula Maloberti,Alejandra Duarte,Cecilia Poderoso,Ulises Daniel Orlando,Cristina Paz,Fabiana Cornejo Maciel,Ernesto J. Podestá +8 more
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TLDR
The role of protein tyrosine phosphatases is described, relating them to steroidogenic acute regulatory protein, arachidonic acid metabolism and mitochondrial rearrangement.About:
This article is published in Molecular and Cellular Endocrinology.The article was published on 2011-04-10. It has received 15 citations till now. The article focuses on the topics: Protein tyrosine phosphatase & Receptor tyrosine kinase.read more
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Journal ArticleDOI
Mitochondrial fusion is essential for steroid biosynthesis.
Alejandra Duarte,Cecilia Poderoso,Mariana Cooke,Gastón Soria,Fabiana Cornejo Maciel,Vanesa Gottifredi,Ernesto J. Podestá +6 more
TL;DR: It is shown that the hormonal stimulation triggers mitochondrial fusion into tubular-shaped structures and it is demonstrated that mitochondrial fusion does not only correlate-with but also is an essential step of steroid production, being both events depend on PKA activity.
Journal ArticleDOI
60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH
TL;DR: The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and stress response and is thus the major component of the hypothalamo-pituitary-adrenal axis and the mechanisms involved in steroid secretion are reviewed.
OtherDOI
Steroidogenesis-adrenal cell signal transduction.
TL;DR: Many of the aspects addressed in this article still represent a challenge for future studies, their outcome aimed at providing evidence that the adrenal gland, through its steroid hormones, occupies a central position in many situations where homeostasis is disrupted, thus highlighting the relevance of exploring and understanding how this key organ is regulated.
Journal ArticleDOI
Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes.
TL;DR: This review provides a general view of the transcriptional control exerted by the ACTH/cAMP system on the expression of genes encoding for steroidogenic enzymes in the adrenal cortex, with special emphasis on the transcription factors required to mediate ACTH-dependent transcription of steroidogenic genes.
Journal ArticleDOI
Repeated immobilization stress disturbed steroidogenic machinery and stimulated the expression of cAMP signaling elements and adrenergic receptors in Leydig cells.
Natasa J. Stojkov,Marija M. Janjic,Maja M. Bjelic,Aleksandar I. Mihajlović,Tatjana S. Kostic,Silvana A. Andric +5 more
TL;DR: New molecular/transcriptional base for "fight/adaptation" of Leydig cells is provided and new insights into the role of cAMP, epinephrine, and glucocorticoid signaling in recovery of stress-impaired Leydigs cell steroidogenesis are provided.
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Journal ArticleDOI
Protein Tyrosine Phosphatases in the Human Genome
Andres Alonso,Joanna Sasin,Nunzio Bottini,Ilan Friedberg,Iddo Friedberg,Andrei L. Osterman,Adam Godzik,Tony Hunter,Jack E. Dixon,Tomas Mustelin +9 more
TL;DR: The set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families are presented and the role of these enzymes in human disease will be discussed.
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The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
TL;DR: A small, highly conserved subfamily of protein-tyrosine phosphatases, members of which are present in both vertebrates and invertebrates, and the key targets of each Shp have remained elusive are identified.
Journal ArticleDOI
SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases
TL;DR: A mouse phosphotyrosine phosphatase containing two Src homology 2 (SH2) domains, Syp, was identified and was rapidly phosphorylated on tyrosine in PDGF- and EGF-stimulated cells.
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Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.
TL;DR: PTP 1D was phosphorylated on tyrosine in cells overexpressing the beta PDGF receptor kinase and this tyrosin phosphorylation correlated with an enhancement of its catalytic activity, suggesting that protein tyrosines and phosphatases may work in concert to maintain a fine balance of effector activation needed for the regulation of cell growth and differentiation.