Update on melatonin receptors: IUPHAR Review 20.
Ralf Jockers,Ralf Jockers,Ralf Jockers,Philippe Delagrange,Margarita L. Dubocovich,Regina P. Markus,Nicolas Renault,Gianluca Tosini,Erika Cecon,Erika Cecon,Erika Cecon,Darius P. Zlotos +11 more
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TLDR
The current review provides an update on melatonin receptors by the corresponding subcommittee of the International Union of Basic and Clinical Pharmacology, and highlights recent developments of melatonin receptor ligands, including radioligands, and gives anupdate on the latest phenotyping results ofmelatonin receptor knockout mice.Abstract:
Melatonin receptors are seven transmembrane-spanning proteins belonging to the G protein-coupled receptor super-family. In mammals, two melatonin receptor subtypes exit MT1 and MT2 encoded by the MTNR1A and MTNR1B genes, respectively. The current review provides an update on melatonin receptors by the corresponding sub-committee of the International Union of Basic and Clinical Pharmacology. We will highlight recent developments of melatonin receptor ligands, including radioligands and give an update on the latest phenotyping results of melatonin receptor knockout mice. The current status and perspectives of the structure of melatonin receptor structures will be summarized. The physiological importance of melatonin receptor dimers and biologically important and type 2 diabetes-associated genetic variants of melatonin receptors will be discussed. The role of melatonin receptors in physiology and disease will be further exemplified by its functions in the immune system and the central nervous system. Finally, antioxidant and free radical scavenger properties of melatonin and its relation to melatonin receptors will be critically addressed.read more
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Melatonin Synthesis and Function: Evolutionary History in Animals and Plants.
TL;DR: In present day animals, via receptor-mediated means, melatonin functions in the regulation of sleep, modulation of circadian rhythms, enhancement of immunity, as a multifunctional oncostatic agent, etc., while retaining its ability to reduce oxidative stress by processes that are, in part, receptor-independent.
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Melatonin as a hormone: new physiological and clinical insights
TL;DR: Maternal melatonin programs the fetuses' behavior and physiology to cope with the environmental light/dark cycle and season after birth, and unique ways of action turn melatonin into a biological time-domain-acting molecule.
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A brief review about melatonin, a pineal hormone
TL;DR: The present review aims to focus on melatonin as a pineal hormone with specific mechanisms and ways of action, besides presenting the clinical syndromes related to its synthesis and/or function disruptions.
Journal ArticleDOI
Melatonin and Hippo Pathway: Is There Existing Cross-Talk?
TL;DR: The structure and functions of melatonin and its receptors are described, and both molecular and epidemiological evidence on melatonin anticancer effects are discussed, to shed light on potential cross-talk between melatonin signaling and the Hippo signaling pathway.
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Melatonin in type 2 diabetes mellitus and obesity
Angeliki Karamitri,Angeliki Karamitri,Angeliki Karamitri,Ralf Jockers,Ralf Jockers,Ralf Jockers +5 more
TL;DR: The rs10830963 single-nucleotide polymorphism (SNP) in the MTNR1B locus is associated with increased fasting plasma glucose levels and impaired insulin secretion, as well as increased risk of type 2 diabetes mellitus (T2DM) and gestational Diabetes mellitus.
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One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?
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