Journal ArticleDOI
Updates on the pathogenicity status of Pseudomonas aeruginosa
Mohd Azam,Asad U. Khan +1 more
TLDR
Different aspects of resistance and pathogenicity in P. aeruginosa, such as the role of outer membrane proteins, transcriptional regulators, efflux pumps, enzymes, and biofilms in antimicrobial resistance, are highlighted.About:
This article is published in Drug Discovery Today.The article was published on 2019-01-01. It has received 183 citations till now. The article focuses on the topics: Pseudomonas aeruginosa & Drug resistance.read more
Citations
More filters
Journal ArticleDOI
High-Affinity Chemotaxis to Histamine Mediated by the TlpQ Chemoreceptor of the Human Pathogen Pseudomonas aeruginosa.
Andrés Corral-Lugo,Miguel A. Matilla,David Martín-Mora,Hortencia Silva Jiménez,Noel Mesa Torres,Junichi Kato,Akiko Hida,Shota Oku,Mayte Conejero-Muriel,Jose A. Gavira,Tino Krell +10 more
TL;DR: The first report of bacterial histamine chemotaxis in the human pathogen Pseudomonas aeruginosa is reported, and this chemotactic response is mediated by the concerted action of the TlpQ, PctA, and PctC chemoreceptors, which display differing sensitivities to histamine.
Journal ArticleDOI
Combination of gallium(III) with acetate for combating antibiotic resistant Pseudomonas aeruginosa
Yuchuan Wang,Yuchuan Wang,Bingjie Han,Yanxuan Xie,Haibo Wang,Runming Wang,Wei Xia,Hongyan Li,Hongzhe Sun +8 more
TL;DR: Combination of Ga(iii) with acetate greatly enhances the antimicrobial activity of Ga (iii) against P. aeruginosa, and shows promise to combat the crisis of antimicrobial resistance.
Journal ArticleDOI
Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review
András Fodor,Birhan Addisie Abate,Péter Deák,Péter Deák,László Fodor,Ervin Gyenge,Michael G. Klein,Zsuzsanna Koncz,Josephat Muvevi,Laszlo Otvos,Gyöngyi Székely,Dávid Vozik,László Makrai +12 more
TL;DR: It is theorized that the suggested post-antibiotic era has not yet come, and indeed might never come, because of the species-specificity of resistance genes.
Journal ArticleDOI
Characterization of the virulence of Pseudomonas aeruginosa strains causing ventilator-associated pneumonia
Beatriz Alonso,Laia Fernández-Barat,Enea Gino Di Domenico,Mercedes Marín,Emilia Cercenado,Irene Merino,Manuela de Pablos,Patricia Muñoz,María Guembe +8 more
TL;DR: The virulence of VAP- Pseudomonas aeruginosa does not depend on biofilm formation, production of pyoverdine or the presence of some virulence genes compared to P. aerug inosa isolated from non-invasive locations, but VAP strains showed attenuated virulence compared to non-VAP strains in an in vivo model of G. mellonella.
Journal ArticleDOI
Disarming Pseudomonas aeruginosa Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione-Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target
Anna Clara M. Galdino,Livia Viganor,Alexandre A. de Castro,Elaine F. F. da Cunha,Thaís P. Mello,Larissa Maura Melo Mattos,Marcos D. Pereira,Mary C. Hunt,Megan O’Shaughnessy,Orla Howe,Michael Devereux,Malachy McCann,Teodorico C. Ramalho,Marta H. Branquinha,André L.S. Santos +14 more
TL;DR: Evaluated compounds reinforced the concept of lasB being a veritable therapeutic target and phendione-based compounds (mainly Cu-phendione) being prospective anti-virulence drugs against P. aeruginosa and protective action for lung epithelial cells.
References
More filters
Journal ArticleDOI
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Charles K. Stover,X. Q. Pham,A. L. Erwin,S. D. Mizoguchi,Paul Warrener,Mark J. Hickey,Fiona S. L. Brinkman,W. O. Hufnagle,D. J. Kowalik,Lagrou Mj,R. L. Garber,L. Goltry,E. Tolentino,S. Westbrock-Wadman,Ying Yuan,L. L. Brody,S. N. Coulter,K. R. Folger,Arnold Kas,K. Larbig,R. Lim,Kelly D. Smith,David H. Spencer,Gane Ka-Shu Wong,Z. Wu,Ian T. Paulsen,Ian T. Paulsen,Jonathan Reizer,Milton H. Saier,Robert E. W. Hancock,Stephen Lory,Maynard V. Olson +31 more
TL;DR: It is proposed that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.
Journal ArticleDOI
PubChem Substance and Compound databases
Sunghwan Kim,Paul A. Thiessen,Evan E Bolton,Jie Chen,Gang Fu,Asta Gindulyte,Lianyi Han,Jane He,Siqian He,Benjamin A. Shoemaker,Jiyao Wang,Bo Yu,Jian-Jian Zhang,Stephen H. Bryant +13 more
TL;DR: An overview of the PubChem Substance and Compound databases is provided, including data sources and contents, data organization, data submission using PubChem Upload, chemical structure standardization, web-based interfaces for textual and non-textual searches, and programmatic access.
Journal ArticleDOI
Mechanisms of Antibiotic Resistance
Jose M. Munita,Cesar A. Arias +1 more
TL;DR: This chapter will describe in detail the major mechanisms of antibiotic resistance encountered in clinical practice, providing specific examples in relevant bacterial pathogens.
Journal ArticleDOI
Quorum sensing signal–response systems in Gram-negative bacteria
Kai Papenfort,Bonnie L. Bassler +1 more
TL;DR: This Review examines how features of quorum sensing signal–response systems combine to control collective behaviours in Gram-negative bacteria and the implications for host–microbial associations and antibacterial therapy.
Journal ArticleDOI
Gene expression in Pseudomonas aeruginosa biofilms
Marvin Whiteley,Gita Bangera,Roger E. Bumgarner,Matthew R. Parsek,Gail M. Teitzel,Stephen Lory,E. P. Greenberg +6 more
TL;DR: DNA microarrays show that gene expression in biofilm cells is similar to that in free-living cells but there are a small number of significant differences, which points to mechanisms of biofilm resistance to antibiotics.
Related Papers (5)
The hierarchy quorum sensing network in Pseudomonas aeruginosa.
Pseudomonas aeruginosa : new insights into pathogenesis and host defenses
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
Charles K. Stover,X. Q. Pham,A. L. Erwin,S. D. Mizoguchi,Paul Warrener,Mark J. Hickey,Fiona S. L. Brinkman,W. O. Hufnagle,D. J. Kowalik,Lagrou Mj,R. L. Garber,L. Goltry,E. Tolentino,S. Westbrock-Wadman,Ying Yuan,L. L. Brody,S. N. Coulter,K. R. Folger,Arnold Kas,K. Larbig,R. Lim,Kelly D. Smith,David H. Spencer,Gane Ka-Shu Wong,Z. Wu,Ian T. Paulsen,Ian T. Paulsen,Jonathan Reizer,Milton H. Saier,Robert E. W. Hancock,Stephen Lory,Maynard V. Olson +31 more