Journal ArticleDOI
Ursolic acid : An anti-and pro-inflammatory triterpenoid
Reads0
Chats0
TLDR
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions that are able to counteract endogenous and exogenous biological stimuli.Abstract:
There is growing interest in the elucidation of the biological functions of triterpenoids, ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer and anti-inflammatory agents in Asian countries. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions, such as antioxidative, anti-inflammation, and anticancer activities, that are able to counteract endogenous and exogenous biological stimuli. In contrast to these beneficial properties, some laboratory studies have recently revealed that the effects of UA on normal cells and tissues are occasionally pro-inflammatory. Thus, UA may be designated as a double-edged sword with both positive and negative effects, and further evaluations of the effects of UA on the biological status of target cells or tissues are necessary. This review summarizes previous and current information regarding UA, and provides new insights into the underlying molecular mechanisms of its activities.read more
Citations
More filters
Journal ArticleDOI
Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders
TL;DR: Research on the effects of OA and UA on neurodegenerative diseases, neuropsychiatric diseases and other brain disorders including ischemic stroke, epilepsy, etc, as well as the potential underlying molecular mechanisms are reviewed.
Journal ArticleDOI
Monolithic Column Prepared with UiO-66-2COOH MOF as Monomer for Enrichment and Purification of Ursolic Acid in Plants by Online Solid-Phase Extraction
TL;DR: In this paper, a metal-organic framework (MOF)-polymer monolith was established by in situ radical polymerization with derivatized UiO-66-2COOH and N-isopropylacrylamide (NIPAAm) as co-monomers.
Journal ArticleDOI
Sentulic acid isolated from Sandoricum koetjape Merr attenuates lipopolysaccharide and interferon gamma co-stimulated nitric oxide production in murine macrophage RAW264 cells.
TL;DR: It is demonstrated that SA attenuates NO production after LPS/IFNγ co-stimulation in RAW264.7 cells by inhibiting the binding of LPS to TLR4, suggesting that SA is beneficial for the treatment of inflammatory diseases.
Journal ArticleDOI
Phytochemistry, antifungal and antioxidant activity, and cytotoxicity of byrsonima gardneriana (A. Juss) extract.
Waleska Ohana de Souza-Melo,Ernani Canuto Figueiredo-Júnior,Julliana Cariry Palhano Freire,Bruna Palmeira Costa,Andressa Brito Lira,Irlan Almeida Freires,Yuri Wanderley Cavalcanti,Wilton Silva Lopes,Josean Fechine Tavares,Hilzeth de Luna Freire Pessôa,Jozinete Vieira Pereira +10 more
TL;DR: In this article, the phytochemical composition of Byrsonima gardneriana (A. Juss) leaf extract (BGE) and its antifungal activity against Candida spp., antioxidant potential and in vitro cytotoxicity were determined.
Journal ArticleDOI
LC-MS Method for the Detection and Quantification of Ursolic Acid and Uvaol Levels in Olive Leaves and Oregano
TL;DR: In this article, a new rapid and validated UPLC method was developed to identify and quantify ursolic acid and uvaol in dry olive leaves (Olea europaea L) planted in Kuwait and dry oregano (Origanum vulgare L.) planted in Palestine and Spain.
References
More filters
Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs
TL;DR: The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.
Journal ArticleDOI
Hydrogen peroxide mediates amyloid beta protein toxicity.
TL;DR: The cytotoxic action of A beta on neurons results from free radical damage to susceptible cells, suggesting that A beta activates a member of this class of enzymes.
Journal ArticleDOI
Molecular targets of dietary agents for prevention and therapy of cancer
TL;DR: Evidence is presented that numerous agents identified from fruits and vegetables can interfere with several cell-signaling pathways and the active principle identified in fruit and vegetables and the molecular targets modulated may be the basis for how these dietary agents not only prevent but also treat cancer and other diseases.
Journal ArticleDOI
Radical causes of cancer
TL;DR: Understanding the association between chronic inflammation and cancer provides insights into the molecular mechanisms involved and highlights the interaction between nitric oxide and p53 as a crucial pathway in inflammatory-mediated carcinogenesis.