Journal ArticleDOI
Ursolic acid : An anti-and pro-inflammatory triterpenoid
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TLDR
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions that are able to counteract endogenous and exogenous biological stimuli.Abstract:
There is growing interest in the elucidation of the biological functions of triterpenoids, ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer and anti-inflammatory agents in Asian countries. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions, such as antioxidative, anti-inflammation, and anticancer activities, that are able to counteract endogenous and exogenous biological stimuli. In contrast to these beneficial properties, some laboratory studies have recently revealed that the effects of UA on normal cells and tissues are occasionally pro-inflammatory. Thus, UA may be designated as a double-edged sword with both positive and negative effects, and further evaluations of the effects of UA on the biological status of target cells or tissues are necessary. This review summarizes previous and current information regarding UA, and provides new insights into the underlying molecular mechanisms of its activities.read more
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Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies
TL;DR: This review not only summarizes the diverse molecular targets of ursolic acid, but also provides an insight into the various preclinical and clinical studies that have been performed in the last decade with this promising triterpenoid.
Journal ArticleDOI
Cranberries and Their Bioactive Constituents in Human Health
Jeffrey B. Blumberg,Terri A. Camesano,Aedin Cassidy,Penny M. Kris-Etherton,Amy B. Howell,Claudine Manach,Luisa M. Ostertag,Helmut Sies,Ann C. Skulas-Ray,Joseph A. Vita +9 more
TL;DR: Evidence suggesting that cranberries may decrease the recurrence of urinary tract infections is important because a nutritional approach to this condition could lower the use of antibiotic treatment and the consequent development of resistance to these drugs.
Journal ArticleDOI
Potent Anti-Inflammatory Activity of Ursolic Acid, a Triterpenoid Antioxidant, Is Mediated through Suppression of NF-κB, AP-1 and NF-AT
Rahul Checker,Santosh K. Sandur,Deepak Sharma,Raghavendra S. Patwardhan,Sundarraj Jayakumar,Vineet Kohli,Gautam Sethi,Bharat B. Aggarwal,Krishna B. Sainis +8 more
TL;DR: Ursolic acid treatment inhibited T cell activation even when added post-mitogenic stimulation demonstrating its therapeutic utility as an anti-inflammatory agent.
Journal ArticleDOI
Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein *
TL;DR: It is shown that ursolic acid (UA), a small molecule present in herbal medicine, selectively and effectively inhibits the function of RORγt, resulting in greatly decreased IL-17 expression in both developing and differentiated Th17 cells.
Journal ArticleDOI
Traditional Uses, Phytochemistry, and Pharmacology of Olea europaea (Olive)
TL;DR: The outcomes of phytochemical and pharmacological studies reported in this review will further expand its existing therapeutic potential and provide a convincing support to its future clinical use in modern medicine.
References
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Journal ArticleDOI
Anti-inflammatory activity of natural products (I) triterpenoids
TL;DR: The anti-inflammatory activity of a number of triterpenoids and a nor-triterpenoid isolated from Indian plants has been tested against carrageenin-induced oedema and formaldehyde-induced arthritis in albino rats.
Journal ArticleDOI
Determination of oleanolic acid, ursolic acid and amygdalin in the flower of Eriobotrya japonica Lindl. by HPLC
TL;DR: Application of simple and accurate HPLC methods to determine the OA, UA and amygdalin contents in loquat flower showed that cultivar had a minor effect on the contents of all three compounds, with average amounts of 0.38-0.51 mg OA/g dry weight (DW), 2.15-2.68 mg UA/g DW and 1.23-1.56 mg Amygdalin/gDW among five loquats tested.
Journal Article
Ursolic acid of Origanum majorana L. reduces Abeta-induced oxidative injury.
Ho-Jin Heo,Hong-Yon Cho,Bum-Shik Hong,Hye Kyung Kim,Tae-Ryeon Heo,Eun-Ki Kim,Sung-Koo Kim,Chang-Ju Kim,Dong-Hoon Shin +8 more
TL;DR: Results indicate that micromolar Abeta-induced oxidative cell death is reduced by ursolic acid from Origanum majorana L, and treatment with these antioxidants inhibited the Abeta -induced neurotoxic effect.
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Anti-inflammatory effect of Pimenta racemosa var. ozua and isolation of the triterpene lupeol.
TL;DR: Results show that the methanol extract from the leaves of Pimenta racemosa var.
Journal ArticleDOI
In vitro anti-inflammatory activity of iridoids and triterpenoid compounds isolated from Phillyrea latifolia L.
A. M. Diaz,María José Abad,Lidia Fernandez,Cristina Recuero,Lucinda Villaescusa,Ana Maria Silván,Paulina Bermejo +6 more
TL;DR: Two iridoids and two triterpenoid compounds isolated from the leaves of Phillyrea latifolia have been isolated and possess an array of potentially beneficial anti-inflammatory properties which may, alongside other constituents, contribute to the claimed therapeutic properties of the plant from which they are derived.