Journal ArticleDOI
Ursolic acid : An anti-and pro-inflammatory triterpenoid
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TLDR
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions that are able to counteract endogenous and exogenous biological stimuli.Abstract:
There is growing interest in the elucidation of the biological functions of triterpenoids, ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer and anti-inflammatory agents in Asian countries. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions, such as antioxidative, anti-inflammation, and anticancer activities, that are able to counteract endogenous and exogenous biological stimuli. In contrast to these beneficial properties, some laboratory studies have recently revealed that the effects of UA on normal cells and tissues are occasionally pro-inflammatory. Thus, UA may be designated as a double-edged sword with both positive and negative effects, and further evaluations of the effects of UA on the biological status of target cells or tissues are necessary. This review summarizes previous and current information regarding UA, and provides new insights into the underlying molecular mechanisms of its activities.read more
Citations
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Original article: THE EFFECTS OF URSOLIC ACID ON CYTOKINE PRODUCTION VIA THE MAPK PATHWAYS IN LEUKEMIC T-CELLS
TL;DR: In this article, the effect of Ursolic acid (UA) on cytokine production via the MAPK pathways in Jurkat leukemic T-cells was investigated, showing that UA inhibited cell growth and proliferation of Jurkat cells, as well as suppressing PMA/PHA induced IL-2 and TNF-α production.
Journal ArticleDOI
Effect of the solvent and the sample preparation on the determination of triterpene compounds in two-phase olive-mill-waste samples.
TL;DR: A simple and rapid extraction method has been employed to determine several value-added compounds, mainly triterpenes, in two-phase olive-mill-waste samples, and an ultra performance liquid chromatography-mass spectrometry method was employed.
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Interactions of pentacyclic triterpene acids with cardiolipins and related phosphatidylglycerols in model systems
TL;DR: The studies proved that PTAs can disturb the organization of CL-rich domains and affect the bacterial membrane fluidity by the interactions with phosphatidylglycerols, so anionic phospholipids are the targets of their membrane action.
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An ursolic acid-enriched extract of Cynomorium songaricum protects against carbon tetrachloride hepatotoxicity and gentamicin nephrotoxicity in rats possibly through a mitochondrial pathway: A comparison with ursolic acid
TL;DR: The results indicated that HCY2 pretreatment protected against CCl4 hepatotoxicity and gentamicin nephrotoxicity, as evidenced by the significant inhibition of plasma aspartate aminotransferase and alanine aminotsferases activities as well as decreases in plasma creatinine and blood urea nitrogen levels, respectively.
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Glycan Mimetics from Natural Products: New Therapeutic Opportunities for Neurodegenerative Disease
TL;DR: A number of natural products that functionally mimic glycans to protect neurons, which therefore represent promising new therapeutic approaches for patients with NDs are discussed.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs
TL;DR: The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.
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Hydrogen peroxide mediates amyloid beta protein toxicity.
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Molecular targets of dietary agents for prevention and therapy of cancer
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TL;DR: Understanding the association between chronic inflammation and cancer provides insights into the molecular mechanisms involved and highlights the interaction between nitric oxide and p53 as a crucial pathway in inflammatory-mediated carcinogenesis.