Journal ArticleDOI
Ursolic acid : An anti-and pro-inflammatory triterpenoid
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TLDR
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions that are able to counteract endogenous and exogenous biological stimuli.Abstract:
There is growing interest in the elucidation of the biological functions of triterpenoids, ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer and anti-inflammatory agents in Asian countries. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions, such as antioxidative, anti-inflammation, and anticancer activities, that are able to counteract endogenous and exogenous biological stimuli. In contrast to these beneficial properties, some laboratory studies have recently revealed that the effects of UA on normal cells and tissues are occasionally pro-inflammatory. Thus, UA may be designated as a double-edged sword with both positive and negative effects, and further evaluations of the effects of UA on the biological status of target cells or tissues are necessary. This review summarizes previous and current information regarding UA, and provides new insights into the underlying molecular mechanisms of its activities.read more
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Journal ArticleDOI
Anti-inflammatory effects of methyl ursolate obtained from a chemically derived crude extract of apple peels: potential use in rheumatoid arthritis.
Tatiana Almeida Pádua,Bianca S. S. C. de Abreu,Thadeu Estevam Moreira Maramaldo Costa,Marcos J. Nakamura,Ligia M. M. Valente,Maria das Graças Henriques,Antonio Carlos Siani,Elaine Cruz Rosas +7 more
TL;DR: Methyl ursolate (MU) may be considered to be a useful anti-inflammatory derivative to overcome the inherent poor solubility of UA for formulating pharmaceutical products.
Journal ArticleDOI
Nephroprotective Role of Resveratrol and Ursolic Acid in Aristolochic Acid Intoxicated Zebrafish
TL;DR: The findings reveal that AA-induced nephrotoxicities can be attenuated by pre-treatment with either Resv or UA, and believes that zebrafish represent an efficient model for screening AA-protective natural compounds.
Journal ArticleDOI
Structural modifications of 2,3-indolobetulinic acid: Design and synthesis of highly potent α-glucosidase inhibitors.
E. F. Khusnutdinova,Anastasiya V. Petrova,Ha Nguyen Thi Thu,Anh Le Thi Tu,Tra Nguyen Thanh,Cham Ba Thi,Denis A. Babkov,Oxana B. Kazakova +7 more
TL;DR: This study revealed that 2,3-indolo-platanic acid is 4.5 times more active than the parent triterpenoid with IC50 of 0.4 μM, and molecular modeling suggested that improved potency is due to additional polar interactions formed between C28 side chain and a sub-pocket of the α-glucosidase allosteric site.
Journal ArticleDOI
Ursolic acid triggers nonprogrammed death (necrosis) in human glioblastoma multiforme DBTRG-05MG cells through MPT pore opening and ATP decline
TL;DR: This study is the first to report that ursolic acid-modified mitochondrial function triggers defective death by necrosis in DBTRG-05MG cells rather than augmenting programmed death.
Journal ArticleDOI
Unusual immuno-modulatory triterpene-caffeates in the skins of russeted varieties of apples and pears.
Christelle M. Andre,Lesley Larsen,Elaine J. Burgess,Dwayne J. Jensen,Janine M. Cooney,Danièle Evers,Jingli Zhang,Nigel B. Perry,William A. Laing +8 more
TL;DR: Betulinic acid-3-trans-caffeate, the predominant compound in the apples, was immuno-modulatory at around 10 μM in the in vitro and ex vivo bioassays, boosting production of the pro-inflammatory cytokine TNFα in cells stimulated with bacterial lipopolysaccharides.
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