Journal ArticleDOI
Ursolic acid : An anti-and pro-inflammatory triterpenoid
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TLDR
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions that are able to counteract endogenous and exogenous biological stimuli.Abstract:
There is growing interest in the elucidation of the biological functions of triterpenoids, ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer and anti-inflammatory agents in Asian countries. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions, such as antioxidative, anti-inflammation, and anticancer activities, that are able to counteract endogenous and exogenous biological stimuli. In contrast to these beneficial properties, some laboratory studies have recently revealed that the effects of UA on normal cells and tissues are occasionally pro-inflammatory. Thus, UA may be designated as a double-edged sword with both positive and negative effects, and further evaluations of the effects of UA on the biological status of target cells or tissues are necessary. This review summarizes previous and current information regarding UA, and provides new insights into the underlying molecular mechanisms of its activities.read more
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Pentacyclic triterpenoids from Mitracarpus frigidus (Willd. ex Roem. & Schult.) K. Shum: in vitro cytotoxic and leishmanicidal and in vivo anti-inflammatory and antioxidative activities
Rodrigo Luiz Fabri,Roberta Alvim Garcia,Jônatas Rodrigues Florêncio,Lidiane Oliveira de Carvalho,Nícolas de Castro Campos Pinto,Elaine Soares Coimbra,Elaine M. Souza-Fagundes,Antônia Ribeiro,Elita Scio +8 more
TL;DR: These compounds, hitherto unknown in the species, were evaluated for their in vitro biological activities against four tumor cell lines and four Leishmania species and reinforced that pentacyclic triterpenoids are an important class of natural products for investigation in the search of new bioactive compounds.
Journal ArticleDOI
Ursolic acid activates the TGR5 receptor to enhance GLP-1 secretion in type 1-like diabetic rats.
TL;DR: It is demonstrated that ursolic acid can activate TGR5, enhancing GLP-1 secretion in vitro and in vivo, and is more effective than betulinic acid in reduction of hyperglycemia and increase of GLP -1 secretion.
Journal ArticleDOI
Interference of ursolic acid treatment with glioma growth: An in vitro and in vivo study.
Letícia Scussel Bergamin,Fabrício Figueiró,Fabrícia Dietrich,Fabiana Manica,Eduardo C. Filippi-Chiela,Franciane Brackman Mendes,Elisa Helena Farias Jandrey,Daniela Vasconcelos Lopes,Francine Hehn de Oliveira,Isis C. Nascimento,Henning Ulrich,Ana Maria Oliveira Battastini +11 more
TL;DR: In vitro results showed that UA decreased glioma cell numbers, increased the sub-G1 fraction and induced apoptotic death, accompanied by increased active caspase-3 protein levels, and ursolic acid may be a potential candidate as an adjuvant for glioblastoma therapy.
Journal ArticleDOI
Synthesis and biological evaluation of ursolic acid derivatives containing an aminoguanidine moiety
TL;DR: In anti-inflammatory tests, most of the compounds exhibited potent activity, in particular compound 3a displayed the most potent activity with 81.61% inhibition after intraperitoneal administration, which was more potent than ursolic acid and the reference drugs (ibuprofen and indomethacin).
Journal ArticleDOI
Dietary 23-hydroxy ursolic acid protects against atherosclerosis and obesity by preventing dyslipidemia-induced monocyte priming and dysfunction
TL;DR: Dietary 23-OHUA reduces weight gain and attenuates atherogenesis in mice by protecting monocytes against metabolic stress-induced priming and dysfunction, and may represent a novel therapeutic approach for the prevention and treatment of obesity and atherosclerosis.
References
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