Journal ArticleDOI
Ursolic acid : An anti-and pro-inflammatory triterpenoid
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TLDR
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions that are able to counteract endogenous and exogenous biological stimuli.Abstract:
There is growing interest in the elucidation of the biological functions of triterpenoids, ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer and anti-inflammatory agents in Asian countries. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions, such as antioxidative, anti-inflammation, and anticancer activities, that are able to counteract endogenous and exogenous biological stimuli. In contrast to these beneficial properties, some laboratory studies have recently revealed that the effects of UA on normal cells and tissues are occasionally pro-inflammatory. Thus, UA may be designated as a double-edged sword with both positive and negative effects, and further evaluations of the effects of UA on the biological status of target cells or tissues are necessary. This review summarizes previous and current information regarding UA, and provides new insights into the underlying molecular mechanisms of its activities.read more
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Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies
TL;DR: This review not only summarizes the diverse molecular targets of ursolic acid, but also provides an insight into the various preclinical and clinical studies that have been performed in the last decade with this promising triterpenoid.
Journal ArticleDOI
Cranberries and Their Bioactive Constituents in Human Health
Jeffrey B. Blumberg,Terri A. Camesano,Aedin Cassidy,Penny M. Kris-Etherton,Amy B. Howell,Claudine Manach,Luisa M. Ostertag,Helmut Sies,Ann C. Skulas-Ray,Joseph A. Vita +9 more
TL;DR: Evidence suggesting that cranberries may decrease the recurrence of urinary tract infections is important because a nutritional approach to this condition could lower the use of antibiotic treatment and the consequent development of resistance to these drugs.
Journal ArticleDOI
Potent Anti-Inflammatory Activity of Ursolic Acid, a Triterpenoid Antioxidant, Is Mediated through Suppression of NF-κB, AP-1 and NF-AT
Rahul Checker,Santosh K. Sandur,Deepak Sharma,Raghavendra S. Patwardhan,Sundarraj Jayakumar,Vineet Kohli,Gautam Sethi,Bharat B. Aggarwal,Krishna B. Sainis +8 more
TL;DR: Ursolic acid treatment inhibited T cell activation even when added post-mitogenic stimulation demonstrating its therapeutic utility as an anti-inflammatory agent.
Journal ArticleDOI
Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein *
TL;DR: It is shown that ursolic acid (UA), a small molecule present in herbal medicine, selectively and effectively inhibits the function of RORγt, resulting in greatly decreased IL-17 expression in both developing and differentiated Th17 cells.
Journal ArticleDOI
Traditional Uses, Phytochemistry, and Pharmacology of Olea europaea (Olive)
TL;DR: The outcomes of phytochemical and pharmacological studies reported in this review will further expand its existing therapeutic potential and provide a convincing support to its future clinical use in modern medicine.
References
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Journal ArticleDOI
The triterpenoid CDDO induces apoptosis in refractory CLL B cells
Irene M. Pedersen,Shinichi Kitada,Aaron D. Schimmer,Youngsoo Kim,Juan M. Zapata,Lula Charboneau,Laura Z. Rassenti,Michael Andreeff,Frank C. Bennett,Michael B. Sporn,Lance D. Liotta,Thomas J. Kipps,John C. Reed +12 more
TL;DR: The effects of CDDO on CLL B cells in vitro suggest that the synthetic triterpenoid CDDO should be further explored as a possible therapeutic agent for treatment of chemo-resistant CLL.
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Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas.
María del Carmen Recio,Rosa M. Giner,S. Máñez,Joseph Gueho,H. R. Julien,Kurt Hostettmann,José-Luis Ríos +6 more
TL;DR: Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid and showed anti-inflammatory activity in the carrageenan and serotonin paw edema tests and TPA and EPP ear edema Tests.
Journal ArticleDOI
Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells
Kenneth R. Youngman,Philip Leonard Simon,Gail West,Fabio Cominelli,Daniel Rachmilewitz,John S. Klein,Claudio Fiocchi +6 more
TL;DR: In normal and inflamed human intestine there is a distinct compartmentalization of IL-1, as mononuclear but not epithelial cells generate this cytokine, and blockade by specific antagonists could have important therapeutic effects.
Journal ArticleDOI
c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells
Wei Zou,Xiangguo Liu,Ping Yue,Zhongmei Zhou,Michael B. Sporn,Reuben Lotan,Fadlo R. Khuri,Shi-Yong Sun +7 more
TL;DR: It is concluded that CDDO-Me induces apoptosis via the JNK-mediated DR up-regulation in human lung cancer cells through a p53-independent mechanism.
Journal ArticleDOI
Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris.
Shi Yong Ryu,Min-Ho Oak,Seok Keun Yoon,Dong Im Cho,Gyurng Soo Yoo,Tae Sung Kim,Kyeong Man Kim +6 more
TL;DR: The activity-guided fractionation of the extract of the herb of Prunella vulgaris (Labiatae) led to the isolation of four triterpenes, i.e., betulinic acid, ursolic acid, 2 alpha,3 alpha-dihydroxyurs-12-en-28-oic Acid, and 2 alpha-hydroxyursolic Acid, which exhibited strong inhibitory activities.