Journal ArticleDOI
Ursolic acid : An anti-and pro-inflammatory triterpenoid
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TLDR
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions that are able to counteract endogenous and exogenous biological stimuli.Abstract:
There is growing interest in the elucidation of the biological functions of triterpenoids, ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer and anti-inflammatory agents in Asian countries. Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid, is the major component of some traditional medicine herbs and is well known to possess a wide range of biological functions, such as antioxidative, anti-inflammation, and anticancer activities, that are able to counteract endogenous and exogenous biological stimuli. In contrast to these beneficial properties, some laboratory studies have recently revealed that the effects of UA on normal cells and tissues are occasionally pro-inflammatory. Thus, UA may be designated as a double-edged sword with both positive and negative effects, and further evaluations of the effects of UA on the biological status of target cells or tissues are necessary. This review summarizes previous and current information regarding UA, and provides new insights into the underlying molecular mechanisms of its activities.read more
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Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies
TL;DR: This review not only summarizes the diverse molecular targets of ursolic acid, but also provides an insight into the various preclinical and clinical studies that have been performed in the last decade with this promising triterpenoid.
Journal ArticleDOI
Cranberries and Their Bioactive Constituents in Human Health
Jeffrey B. Blumberg,Terri A. Camesano,Aedin Cassidy,Penny M. Kris-Etherton,Amy B. Howell,Claudine Manach,Luisa M. Ostertag,Helmut Sies,Ann C. Skulas-Ray,Joseph A. Vita +9 more
TL;DR: Evidence suggesting that cranberries may decrease the recurrence of urinary tract infections is important because a nutritional approach to this condition could lower the use of antibiotic treatment and the consequent development of resistance to these drugs.
Journal ArticleDOI
Potent Anti-Inflammatory Activity of Ursolic Acid, a Triterpenoid Antioxidant, Is Mediated through Suppression of NF-κB, AP-1 and NF-AT
Rahul Checker,Santosh K. Sandur,Deepak Sharma,Raghavendra S. Patwardhan,Sundarraj Jayakumar,Vineet Kohli,Gautam Sethi,Bharat B. Aggarwal,Krishna B. Sainis +8 more
TL;DR: Ursolic acid treatment inhibited T cell activation even when added post-mitogenic stimulation demonstrating its therapeutic utility as an anti-inflammatory agent.
Journal ArticleDOI
Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein *
TL;DR: It is shown that ursolic acid (UA), a small molecule present in herbal medicine, selectively and effectively inhibits the function of RORγt, resulting in greatly decreased IL-17 expression in both developing and differentiated Th17 cells.
Journal ArticleDOI
Traditional Uses, Phytochemistry, and Pharmacology of Olea europaea (Olive)
TL;DR: The outcomes of phytochemical and pharmacological studies reported in this review will further expand its existing therapeutic potential and provide a convincing support to its future clinical use in modern medicine.
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