Book ChapterDOI
Xenograft, Transgenic, and Knockout Models of Prostate Cancer
Ann-Christin Gaupel,Wei-Lin Winnie Wang,Sarah Mordan-McCombs,Edmund Chun Yu Lee,Martin Tenniswood +4 more
- pp 973-995
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TLDR
While very few of the transgenic and knockout systems recapitulate the entire natural history of prostate cancer, individual model systems provide valuable genetic insight into the biological consequences of disrupting prostate homeostasis.Abstract:
In humans, the natural history of prostate cancer spans 30–40 years, which makes it a difficult disease to model in rodents. Furthermore, the molecular pathology of prostate cancer responsible for tumor initiation and progression is complex and often redundant. The sequential changes in oncogene and tumor suppressor gene expression during prostate cancer progression have not been fully delineated. Despite these issues, there are model systems, including carefully designed orthotopic xenograft models, that provide robust platforms for drug evaluation and studying the effects of diet and environmental stress on prostate carcinogenesis. Comprehensive transgenic and knockout models have also been developed that recapitulate individual steps in tumor initiation and metastatic progression and highlight the importance of the tumor microenvironment. While very few of the transgenic and knockout systems recapitulate the entire natural history of prostate cancer, individual model systems provide valuable genetic insight into the biological consequences of disrupting prostate homeostasis.read more
Citations
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Journal ArticleDOI
Curcumin against Prostate Cancer: Current Evidence
TL;DR: All the in vitro and in vivo studies examining the effects of curcumin in prostate cancer, a turmeric-derived polyphenol, have been summarized.
Journal ArticleDOI
Insulin Enhances Migration and Invasion in Prostate Cancer Cells by Up-Regulation of FOXC2.
Phoebe Sarkar,Wendy Lee,Elizabeth D. Williams,Amy A. Lubik,Nataly Stylianou,Ali Shokoohmand,Melanie Lehman,Melanie Lehman,Brett G. Hollier,Jennifer H. Gunter,Colleen C. Nelson +10 more
TL;DR: This study identifies for the first time, a mechanism for insulin-driven cancer cell motility and supports the concept that targeting insulin signaling at the level of the PCa tumor may extend the therapeutic efficacy of ADT.
Journal ArticleDOI
Cellular and Molecular Progression of Prostate Cancer: Models for Basic and Preclinical Research.
Sirin Saranyutanon,Sachin Kumar Deshmukh,Santanu Dasgupta,Sachin Pai,Seema Singh,Ajay P. Singh +5 more
TL;DR: This review is an attempt to succinctly discuss existing information on the cellular and molecular progression of prostate cancer and discusses available model systems and their tested and potential utility in basic and preclinical prostate cancer research.
Journal ArticleDOI
Design and Evaluation of 223Ra-Labeled and Anti-PSMA Targeted NaA Nanozeolites for Prostate Cancer Therapy-Part I.
Malwina Czerwińska,Giulio Fracasso,Marek Pruszynski,Aleksander Bilewicz,Marcin Kruszewski,Agnieszka Majkowska-Pilip,Anna Lankoff +6 more
TL;DR: Results supported the 223RaA-silane-PEG-D2B synthesis and revealed that the final product had a diameter ca.
Journal ArticleDOI
Mesoporous silica MCM-41 and HMS as advanced drug delivery carriers for bicalutamide
Teodora Popova,Borislav Tzankov,Christina Voycheva,Ivanka Spassova,Daniela Kovacheva,Stanislav Tzankov,Denitsa Aluani,Virginia Tzankova,Nikolai Lambov +8 more
TL;DR: The cytotoxicity studies show that bicalutamide loading in mesoporous silica nanoparticles increases its in vitro antitumor activity against prostate adenocarcinoma LNCaP cells with the rank order of potency HMS/B > MCM-41/B-> free bicalUTamide.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal ArticleDOI
Identification of a candidate tumour suppressor gene, MMAC1 , at chromosome 10q23.3 that is mutated in multiple advanced cancers
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Journal Article
LNCaP model of human prostatic carcinoma.
Julius S. Horoszewicz,S S Leong,E Kawinski,J P Karr,H Rosenthal,T. M. Chu,E A Mirand,Gerald P. Murphy +7 more
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Journal ArticleDOI
Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells.
TL;DR: It is concluded that SV40 infection or transformation of mouse cells stimulates the synthesis or enhances the stability of a 54K protein, which appears to be associated with SV40 T antigen in SV40-infected and -transformed cells, and is co-immunoprecipitated by hybridomas sera to SV40 large T antigen.
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