YidC and Oxa1 form dimeric insertion pores on the translating ribosome.
Rebecca Kohler,Daniel Boehringer,Basil J. Greber,Rouven Bingel-Erlenmeyer,Ian Collinson,Christiane Schaffitzel,Nenad Ban +6 more
TLDR
It is suggested that dimers of the YidC and Oxa1 proteins form insertion pores and share a common overall architecture with the SecY monomer.About:
This article is published in Molecular Cell.The article was published on 2009-05-15 and is currently open access. It has received 132 citations till now. The article focuses on the topics: Ribosomal protein & SecYEG Translocon.read more
Citations
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Mechanisms of Integral Membrane Protein Insertion and Folding
TL;DR: A theme of the review is the under-appreciated role of basic thermodynamic principles in MP folding and assembly, which not only dictates the final folded structure but also is the driving force for the evolution of the ribosome-translocon system of assembly.
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The Sec Translocase
TL;DR: This review summarizes the current understanding of the structure-function relationship of the translocon and its interactions with ancillary components during protein translocation and membrane protein insertion.
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Mitochondrial protein import: common principles and physiological networks
TL;DR: Recent studies that indicate how the pathways for mitochondrial protein biogenesis are embedded into a functional network of various other physiological processes, such as energy metabolism, signal transduction, and maintenance of mitochondrial morphology are discussed.
Journal ArticleDOI
Structure and Function of the Mitochondrial Ribosome
Basil J. Greber,Nenad Ban +1 more
TL;DR: Recent high-resolution structural data that have provided unprecedented insight into the structure and function of mitoribosomes in mammals and fungi are reviewed.
References
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UCSF Chimera--a visualization system for exploratory research and analysis.
Eric F. Pettersen,Thomas D. Goddard,Conrad C. Huang,Gregory S. Couch,Daniel M. Greenblatt,Elaine C. Meng,Thomas E. Ferrin +6 more
TL;DR: Two unusual extensions are presented: Multiscale, which adds the ability to visualize large‐scale molecular assemblies such as viral coats, and Collaboratory, which allows researchers to share a Chimera session interactively despite being at separate locales.
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TL;DR: ImageJ is an open source Java-written program that is used for many imaging applications, including those that that span the gamut from skin analysis to neuroscience, and can read most of the widely used and significant formats used in biomedical images.
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The 3′-Terminal Sequence of Escherichia coli 16S Ribosomal RNA: Complementarity to Nonsense Triplets and Ribosome Binding Sites
John Shine,Lynn Dalgarno +1 more
TL;DR: It is suggested that this region of the RNA is able to interact with mRNA and that the 3'-terminal U-U-A(OH) is involved in the termination of protein synthesis through base-pairing with terminator codons.
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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution.
TL;DR: The crystal structure of the large ribosomal subunit from Haloarcula marismortui is determined at 2.4 angstrom resolution, and it includes 2833 of the subunit's 3045 nucleotides and 27 of its 31 proteins.