Showing papers on "Surface plasmon resonance published in 2020"
TL;DR: This review provides the basics of LSPR theory, details the mechanisms at play in plasmon-enhanced nanocatalysis, sheds light onto such nanocAtalyst design, and systematically presents the breadth of organic reactions hence catalyzed.
Abstract: Localized surface plasmon resonance (LSPR) is a physical phenomenon exhibited by nanoparticles of metals including coinage metals, alkali metals, aluminum, and some semiconductors which translates into electromagnetic, thermal, and chemical properties. In the past decade, LSPR has been taken advantage of in the context of catalysis. While plasmonic nanoparticles (PNPs) have been successfully applied toward enhancing catalysis of inorganic reactions such as water splitting, they have also demonstrated exciting performance in the catalysis of organic transformations with potential applications in synthesis of molecules from commodity to pharmaceutical compounds. The advantages of this approach include improved selectivity, enhanced reaction rates, and milder reaction conditions. This review provides the basics of LSPR theory, details the mechanisms at play in plasmon-enhanced nanocatalysis, sheds light onto such nanocatalyst design, and finally systematically presents the breadth of organic reactions hence catalyzed.
287 citations
TL;DR: An opto-microfluidic sensing platform with gold nanospikes, fabricated by electrodeposition, to detect the presence and amount of antibodies specific to the SARS-CoV-2 spike protein in human plasma diluted in 1 mL of buffer solution, demonstrating that this platform offers a promising point-of-care testing tool to complement standard serological assays and make Sars-Cov-2 quantitative diagnostics easier, cheaper, and faster.
195 citations
TL;DR: In this article, a surface plasmon resonance sensor based on D-shaped photonic crystal fiber (PCF) is designed for sensing low refractive indexes, and its performance is investigated numerically by the finite element method (FEM).
130 citations
TL;DR: In this paper, a novel flower-like Ag6Si2O7/Bi2WO6 Z-scheme heterojunction photocatalyst with strong redox capability was fabricated via a facile in situ precipitation strategy and then applied to degrade pharmaceutical antibiotics.
Abstract: The massive consumption and discharge of pharmaceutical antibiotics have driven researchers to explore environment-friendly and effective technology to eliminate them. Herein, a novel flower-like Ag6Si2O7/Bi2WO6 Z-scheme heterojunction photocatalyst with strong redox capability was fabricated via a facile in situ precipitation strategy and then applied to degrade pharmaceutical antibiotics. The as-obtained Ag6Si2O7/Bi2WO6 heterojunction with strong interfacial coupling effects exhibited superior photocatalytic property in comparison with pristine Bi2WO6 and Ag6Si2O7 for the degradation of ciprofloxacin (CIP) and tetracycline hydrochloride (TC) under visible light. The optimized Ag6Si2O7/Bi2WO6 (ASO/BWO-3) showed the maximum photocatalytic performance, and its rate constant for the degradation of CIP was as high as 0.0217 min−1, exceeding that of pristine Bi2WO6 and Ag6Si2O7 by approximately 14.5- and 9.8-fold, respectively. The trapping experiments and ESR analyses revealed that the principal active species responsible for pollutant removal are h+ and ˙O2− species. The PL analysis and EIS measurements further demonstrated that Ag6Si2O7/Bi2WO6 possesses a high separation rate of photogenerated electrons and holes. Its extraordinary photocatalytic performance is ascribed to the synergistic interactions of the Z-scheme hetero-structure and surface plasmon resonance (SPR) effect of the Ag nanoparticles. Remarkably, a separation reaction system was delicately designed and employed to demonstrate the significance of the direct contact between Ag6Si2O7/Bi2WO6 and contaminants for antibiotic degradation. This research may provide a new design concept for constructing highly efficient and stable Z-scheme heterojunction photocatalysts for treating pharmaceutical wastewater.
121 citations
TL;DR: In this paper, a dual-band metamaterial absorber for graphene surface plasmon resonance at terahertz frequency is presented, where the authors use the finite difference time domain (FDTD) method to study the absorption characteristics of homocentric graphene ring and disk nanostructure.
Abstract: In this paper, we present a dual-band metamaterial absorber for graphene surface plasmon resonance at terahertz frequency. We use the finite difference time domain (FDTD) method to study the absorption characteristics of the homocentric graphene ring and disk nanostructure. These simulation results show that the change of the geometrical parameters and the substrate thickness of the nanostructure can change the absorption characteristics and the emergence of dual-band absorption peaks. Moreover, we study the field distribution of nanodisks with different radius in detail. By changing the Fermi level of graphene, the wavelength of their absorption peaks can be adjusted flexibly. In addition, the proposed dual-band absorber also shows a good angle tolerance for both TE and TM polarizations. By calculation the surface-filled water (n = 1.332) and 25% aqueous glucose solution (n = 1.372) for the metamaterial absorber, the sensitivities of mode I and mode II are 5.0 μm/RIU and 15.0 μm/RIU. These research results will have broad application prospects for sensing and spatial light modulators.
120 citations
TL;DR: A highly sensitive and selective plasmonic sensing method was developed for the detection of AFB1 based on enhance-surface plAsmon resonance nanosensor based on pre-complexed N-methacryloyl-l-phenylalanine as a template molecule and functional monomer.
117 citations
TL;DR: A brief review of plasmonic biosensors detailing most recent developments and applications is provided and novel plAsmonic materials such as graphene are highlighted.
Abstract: Plasmonics has drawn significant attention in the area of biosensors for decades due to the unique optical properties of plasmonic resonant nanostructures. While the sensitivity and specificity of molecular detection relies significantly on the resonance conditions, significant attention has been dedicated to the design, fabrication, and optimization of plasmonic substrates. The adequate choice of materials, structures, and functionality goes hand in hand with a fundamental understanding of plasmonics to enable the development of practical biosensors that can be deployed in real life situations. Here we provide a brief review of plasmonic biosensors detailing most recent developments and applications. Besides metals, novel plasmonic materials such as graphene are highlighted. Sensors based on Surface Plasmon Resonance (SPR), Localized Surface Plasmon Resonance (LSPR), and Surface Enhanced Raman Spectroscopy (SERS) are presented and classified based on their materials and structure. In addition, most recent applications to environment monitoring, health diagnosis, and food safety are presented. Potential problems related to the implementation in such applications are discussed and an outlook is presented.
111 citations
TL;DR: This article highlights the applications of plasmonic hot electrons in photodetectors, photocatalysts, photoelectrochemical cells, photovoltaics, biosensors, and chemical sensors and discusses the applications and the design principles of plAsmonic materials and devices.
Abstract: In plasmonic metals, surface plasmon resonance decays and generates hot electrons and hot holes through non-radiative Landau damping. These hot carriers are highly energetic, which can be modulated by the plasmonic material, size, shape, and surrounding dielectric medium. A plasmonic metal nanostructure, which can absorb incident light in an extended spectral range and transfer the absorbed light energy to adjacent molecules or semiconductors, functions as a "plasmonic photosensitizer." This article deals with the generation, emission, transfer, and energetics of plasmonic hot carriers. It also describes the mechanisms of hot electron transfer from the plasmonic metal to the surface adsorbates or to the adjacent semiconductors. In addition, this article highlights the applications of plasmonic hot electrons in photodetectors, photocatalysts, photoelectrochemical cells, photovoltaics, biosensors, and chemical sensors. It discusses the applications and the design principles of plasmonic materials and devices.
110 citations
TL;DR: In this article, a plasmonic photocatalyst with 3D porous microsphere structures was proposed for the complete mineralization of nonpolar gaseous molecules (CH4 and C2H4).
Abstract: In this paper, porous microsphere M-ZnO/CeO2 (M = Ag, Au) plasmonic photocatalyst was prepared through a simple hydrothermal method and in situ photo-deposition. This photocatalyst shows excellent stability and high efficiency in the complete mineralization of nonpolar gaseous molecules (CH4 and C2H4) under the simulated sunlight. The appreciable performance improvements are caused by the formation of heterojunctions and oxygen vacancy defects, the surface plasmon resonance (SPR) of noble metal nanoparticles as well as the 3D porous microsphere structures. Especially in this work, we systematically studied the effect of concentration changes of oxygen vacancy defects on photocatalytic performance by XPS, EPR and Raman characterization. Furthermore, a possible mechanism of photo-oxidation reaction in plasmonic photocatalyst system is discussed below. This study provides new inspiration for designing other plasmonic photocatalysts to remove nonpolar gaseous molecules.
104 citations
TL;DR: A roadmap to deploy plasmonic sensors is provided by reviewing the current successes and by laying out the directions the field is currently taking to increase the use of field-deployed plasMonic sensors at the point-of-care, in the environment and in industries.
Abstract: Plasmonic sensors are ideally suited for the design of small, integrated, and portable devices that can be employed in situ for the detection of analytes relevant to environmental sciences, clinical diagnostics, infectious diseases, food, and industrial applications. To successfully deploy plasmonic sensors, scaled-down analytical devices based on surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) must integrate optics, plasmonic materials, surface chemistry, fluidics, detectors and data processing in a functional instrument with a small footprint. The field has significantly progressed from the implementation of the various components in specifically designed prism-based instruments to the use of nanomaterials, optical fibers and smartphones to yield increasingly portable devices, which have been shown for a number of applications in the laboratory and deployed on site for environmental, biomedical/clinical, and food applications. A roadmap to deploy plasmonic sensors is provided by reviewing the current successes and by laying out the directions the field is currently taking to increase the use of field-deployed plasmonic sensors at the point-of-care, in the environment and in industries.
97 citations
TL;DR: Both the localized surface plasmons resonances of the individual dimer-on-film structures as well as their collective surface lattice resonances (SLR) show a highly sensitive refractive index sensing response.
Abstract: Dimers, two closely spaced metallic nanostructures, are one of the primary nanoscale geometries in plasmonics, supporting high local field enhancements in their interparticle junction under excitation of their hybridized "bonding" plasmon. However, when a dimer is fabricated on a metallic substrate, its characteristics are changed profoundly. Here we examine the properties of a Au dimer on a Au substrate. This structure supports a bright "bonding" dimer plasmon, screened by the metal, and a lower energy magnetic charge transfer plasmon. Changing the dielectric environment of the dimer-on-film structure reveals a broad family of higher-order hybrid plasmons in the visible region of the spectrum. Both of the localized surface plasmons resonances (LSPR) of the individual dimer-on-film structures as well as their collective surface lattice resonances (SLR) show a highly sensitive refractive index sensing response. Implementation of such all-metal magnetic-resonant nanostructures offers a promising route to achieve higher-performance LSPR- and SLR-based plasmonic sensors.
TL;DR: In this paper, a ternary heterojunction photocatalytic degradation ratio of 2,4-dichlorophenol reaches 99.2% under visible light irradiation.
Abstract: Plasmon Ag nanoparticle/Bi2S3 ultrathin nanobelt/oxygen-doped flower-like MoS2 nanosphere ternary heterojunction photocatalysts are fabricated via hydrothermal and photoreduction strategies. The introduction of Ag nanoparticles and defective MoS2 and the formation of heterojunctions can induce localized surface plasmon resonance and promote charge separation, respectively, which can extend the photoresponse to the visible light and near-infrared regions and obviously enhance the photothermal and photocatalytic performances. The ternary heterojunction photocatalysts show that the photocatalytic degradation ratio of 2,4-dichlorophenol reaches 99.2% under visible light irradiation. In addition, the photocatalytic hydrogen evolution rate reaches 526.3 μmol h−1 g−1, which is several times higher than that of pristine MoS2 and Bi2S3. This study offers a new strategy for designing other highly efficient heterojunction photocatalysts. In addition, these ternary heterojunctions show high stability, which is favorable for practical applications in the environmental and energy fields.
TL;DR: By controlling the interfacial energy and growth kinetics, a series of Au-on-AuNR hybrid structures are successfully obtained, with the newly grown Au domains being sphere, polyhedron, and branched wire (nanocoral), making them excellent candidates for plasmonic applications.
Abstract: The localized surface plasmon resonance (LSPR) of plasmonic nanomaterials is highly dependent on their structures. Going beyond simple shape and size, further structural diversification demands the growth of non-wetting domains. Now, two new dimensions of synthetic controls in Au-on-Au homometallic nanohybrids are presented: the number of the Au islands and the emerging shapes. By controlling the interfacial energy and growth kinetics, a series of Au-on-AuNR hybrid structures are successfully obtained, with the newly grown Au domains being sphere and branched wire (nanocoral). The structural variety allowed the LSPR to be fine-tuned in full spectrum range, making them excellent candidates for plasmonic applications. The nanocorals exhibit black-body absorption and outstanding photothermal conversion capability in NIR-II window. In vitro and in vivo experiments verified them as excellent photothermal therapy and photoacoustic imaging agents.
TL;DR: In this article, a new smart biosensor for colorless biomaterial detection is developed, taking the advantages of the strong light-matter interaction of graphene layer and its highly tunable optical properties.
Abstract: Graphene biosensors have received more and more attention over the past two decades in the modern fields including labeled, and label-free sensing owing to their ability to harness of electromagnetic fields in a fantastic way. Among these, label-free graphene plasmonic biosensors have been received significant attention for nano-scale applications. The main aim of this work is to study the detection capacity of the biomaterial-based graphene plasmonic biosensor using three-dimensional finite difference time domain (3D-FDTD) method. Herein, taking the advantages of the strong light–matter interaction of graphene layer and its highly tunable optical properties, a new smart biosensor for colorless biomaterial detection is developed. To evaluate the performance parameters of the proposed bio-nanochip sensor, the effects of different biomaterial are considered. Compared to the previous works, the footprint of the proposed biosensor is too small, i.e. λ /10 where λ is the incident wavelength. Also, the sensitivity and figure of merit (FoM) as main parameters of the biosensor are calculated. Numerical results show that the maximum shift of resonance wavelength is around of 100 nm as the variation of refractive index of biomaterials is 0.3. Through the above result, the maximum sensitivity and FoM of the biosensor are respectively 333.3 nm/RIU and 16.665 RIU.
TL;DR: This Minireview introduces the principles and instrumentation of SPRM, and summarizes the broad and exciting applications ofSPRM to the analysis of single entities.
Abstract: Surface plasmon resonance microscopy (SPRM) is a versatile platform for chemical and biological sensing and imaging. Great progress in exploring its applications, ranging from single-molecule sensing to single-cell imaging, has been made. In this Minireview, we introduce the principles and instrumentation of SPRM. We also summarize the broad and exciting applications of SPRM to the analysis of single entities. Finally, we discuss the challenges and limitations associated with SPRM and potential solutions.
TL;DR: In this paper, a plasmonic assisted Z-scheme assembly for solar fuels production was proposed. But the performance of the composite samples, synthesized by a sol-gel assisted photo-deposition method, gave higher visible light absorption through Surface Plasmon Resonance (SPR), larger BET surface area and hindered recombination of charge carrier.
TL;DR: It is shown that it is possible to quantify proteinbinding kinetics by counting the binding of individual molecules, providing a digital method to measure binding kinetics and analyze heterogeneity of protein behavior.
Abstract: Measuring the binding kinetics of single proteins represents one of the most important and challenging tasks in protein analysis. Here we show that this is possible using a surface plasmon resonance (SPR) scattering technique. SPR is a popular label-free detection technology because of its extraordinary sensitivity, but it has never been used for imaging single proteins. We overcome this limitation by imaging scattering of surface plasmonic waves by proteins. This allows us to image single proteins, measure their sizes and identify them based on their specific binding to antibodies. We further show that it is possible to quantify protein binding kinetics by counting the binding of individual molecules, providing a digital method to measure binding kinetics and analyze heterogeneity of protein behavior. We anticipate that this imaging method will become an important tool for single protein analysis, especially for low volume samples, such as single cells. Plasmonic scattering microscopy (PSM) enables the imaging of single proteins on SPR instruments. The method enables measurement of protein size and binding kinetics and is fully compatible with simultaneous traditional SPR measurements.
TL;DR: In this review, the present sensors are compared and analyzed from the aspects of the geometry, material and dimensions of plasmonic nano-arrays and the main research directions and progress are summarized.
Abstract: For sensors based on the electromagnetic resonance whether the surface plasmon resonance (SPR) or localized surface plasmon resonance (LSPR), enhancing the light-matter interactions is the most critical and important way to improve their performance. Plasmonic nano-arrays are a kind of periodic metal or dielectric nanostructure formed by nanofabrication technology and can effectively enhance the light-matter interactions by tuning structural parameters to cause different optical effects due to their ultra-high degree of freedom. At the same time, a plug-and-play, remote microsensor suitable for limited environments (such as in vivo systems) may be realized due to the rise of lab-on-fiber technology and the progress of nanofabrication technology for unconventional substrates (such as an optical fiber tip). In this paper, the advantages and disadvantages of different nanofabrication technologies are briefly introduced and compared firstly, and then the applications of optical fiber sensors (OFS) based on different plasmonic nano-arrays are reviewed. Plasmonic nano-array OFS are divided into two categories: refractive index sensors based on the sensitivity of the array to the surrounding environment and surface enhanced Raman scattering (SERS) sensors based on the enhancement ability of the local electric field around the array. In this review, the present sensors are compared and analyzed from the aspects of the geometry, material and dimensions of plasmonic nano-arrays and the main research directions and progress are summarized. Finally, the future development trend is proposed.
TL;DR: In this article, a dual-band metamaterial perfect absorber based on a Ag-dielectric-Ag multilayer nanostructure was demonstrated, where the structure of top metal film covers nanoring grooves array.
Abstract: In this paper, we demonstrate a dual-band metamaterial perfect absorber based on a Ag-dielectric-Ag multilayer nanostructure. The structure of top metal film covers nanoring grooves array. A dielectric layer has a function of confining electromagnetic fields. Theoretical analysis shows that two absorption peaks (1059 nm and 1304 nm) with the absorption of 99.2% and 99.9% have been achieved, respectively. The physical origin of perfect absorption peaks are related to the Fabry-Perot resonance effect and localized surface plasmon resonance (LSPR) of the nanoring grooves. Its perfect absorption and resonance wavelength can be well regulated by adjusting the relevant structural parameters. Additionally, the absorber demonstrates good operation angle-polarization-tolerance at wide incident angles (0–60°). We believe that our design has a promising application in plasmon-enhanced photovoltaic, optical absorption switching, and modulator optical communications in the infrared regime.
TL;DR: A biocompatible and robust fiber surface plasmon resonance (SPR) temperature sensor was fabricated based on an alcohol-filled hollow-core fiber that has the potential to realizing multiparameter or distributed temperature measurement.
Abstract: A biocompatible and robust fiber surface plasmon resonance (SPR) temperature sensor was fabricated based on an alcohol-filled hollow-core fiber. The fabrication process of this designed sensor included Ag film coating, liquid injection, and fusion splicing, which was low cost and efficient. Due to the high refractive index sensitivity of the SPR effect and the high thermal optical coefficient of alcohol, the designed sensor performed well in temperature sensing, whose linear sensitivity reached as high as 1.16 nm/°C in the range of 35.5 °C–70.1 °C. Being small in size, low in fabrication cost, and highly sensitive in performance, this sensor is suitable for temperature detection during biological and chemical reactions and has the potential to realizing multiparameter or distributed temperature measurement.
TL;DR: A plasmonic Z-scheme nanohybrid by hydrothermally in-situ growing two-dimensional oxygen-deficient molybdenum oxide (MoO3-x) nanoplates onto 2D graphitic carbon nitride (g-C3N4) nanosheets is reported, which can provide an alternative for fabricating Z- Scheme heterostructures that take advantages of Z-Scheme-induced charge carrier separation.
TL;DR: The prospects and challenges of metal‐enhanced biosensors for future nanomedicine in achieving ultrasensitive and fast medical diagnostics, high‐throughput drug discovery as well as effective and reliable theranostic treatment are discussed.
Abstract: Metal nanoparticles (NP) that exhibit localized surface plasmon resonance play an important role in metal-enhanced fluorescence (MEF) and surface-enhanced Raman scattering (SERS). Among the optical biosensors, MEF and SERS stand out to be the most sensitive techniques to detect a wide range of analytes from ions, biomolecules to macromolecules and microorganisms. Particularly, anisotropic metal NPs with strongly enhanced electric field at their sharp corners/edges under a wide range of excitation wavelengths are highly suitable for developing the ultrasensitive plasmon-enhanced biosensors. In this review, we first highlight the reliable methods for the synthesis of anisotropic gold NPs and silver NPs in high yield, as well as their alloys and composites with good control of size and shape. It is followed by the discussion of different sensing mechanisms and recent advances in the MEF and SERS biosensor designs. This includes the review of surface functionalization, bioconjugation and (directed/self) assembly methods as well as the selection/screening of specific biorecognition elements such as aptamers or antibodies for the highly selective bio-detection. The right combinations of metal nanoparticles, biorecognition element and assay design will lead to the successful development of MEF and SERS biosensors targeting different analytes both in-vitro and in-vivo. Finally, the prospects and challenges of metal-enhanced biosensors for future nanomedicine in achieving ultrasensitive and fast medical diagnostics, high-throughput drug discovery as well as effective and reliable theranostic treatment are discussed.
TL;DR: In this article, a novel TiO2/Cu2O/Al/Al2O3 photoelectrode is manufactured by depositing plasmonic nanoparticles of the non-noble metal Al on the surface of a TiO 2/Cu 2O core/shell heterojunction for the first time.
TL;DR: In this article, a highly sensitive SPR biosensor based on silver (Ag), barium titanate (BaTiO3), graphene, and affinity layer is proposed for the detection of Pseudomonas bacteria.
Abstract: In the present work, a highly sensitive SPR biosensor based on silver (Ag), barium titanate (BaTiO3), graphene, and affinity layer is proposed for the detection of Pseudomonas bacteria. The performance of this proposed sensor has been numerically studied and analyzed for sensitivity, quality parameter, and detection accuracy. The proposed structure used attenuated total reflection (ATR) approach based on the Kretschmann configuration for the investigation of performance parameters. The inclusion of the BaTiO3 layer along with the affinity layer shows the enhancement in the performance of the proposed structure for the detection of Pseudomonas bacteria. A comparison of the proposed structure is drawn with contemporary surface plasmon resonance (SPR) biosensors for the detection of Pseudomonas bacteria, and better performance was shown. This work reports that the maximum sensitivity, quality parameter, and detection accuracy for the proposed sensor are 220 degree/RIU, 101.38 RIU−1, and 7.09 respectively. Therefore, the proposed design finds its application in Pseudomonas bacterial detection as well as opens a new window in the biosensing area.
TL;DR: The design, fabrication, and use of a metal-free (i.e., LSPR-free), topologically tailored nanostructure composed of porous carbon nanowires in an array as a SERS substrate to overcome all problems is demonstrated.
Abstract: Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for vibrational spectroscopy as it provides several orders of magnitude higher sensitivity than inherently weak spontaneous Raman scattering by exciting localized surface plasmon resonance (LSPR) on metal substrates. However, SERS can be unreliable for biomedical use since it sacrifices reproducibility, uniformity, biocompatibility, and durability due to its strong dependence on "hot spots", large photothermal heat generation, and easy oxidization. Here, we demonstrate the design, fabrication, and use of a metal-free (i.e., LSPR-free), topologically tailored nanostructure composed of porous carbon nanowires in an array as a SERS substrate to overcome all these problems. Specifically, it offers not only high signal enhancement (~106) due to its strong broadband charge-transfer resonance, but also extraordinarily high reproducibility due to the absence of hot spots, high durability due to no oxidization, and high compatibility to biomolecules due to its fluorescence quenching capability.
TL;DR: Comparative studies related to the fabrication of self-assembled monolayer (SAM) and the influence of AuNPs on Au chip for Aflatoxin B1 (AFB1) detection using SPRi apparatus are presented and the AuNps modified Au chip was proven to clearly be a better analytical tool.
TL;DR: In this article, the photocatalytic properties for hydrogen production in water splitting under simulated solar light (with AM1.5G filter) with Au nanoparticles (NPs)/ZnxCd1-xS nanowires (NWs) have been demonstrated.
TL;DR: A D-shaped fiber SPR sensor with a composite nanostructure of molybdenum disulfide (MoS2)-graphene to improve the sensor sensitivity and specific detection of glucose was realized.
TL;DR: The present proof-of-principle studies demonstrate the feasibility of the proposed SPR-POF platform for the specific detection of infliximab, in both buffer and human serum, and pave the way for further technological improvements.
Abstract: Different lines of evidence indicate that monitoring the blood levels of therapeutic antibodies, characterized by high inter-individual variability, can help to optimize clinical decision making, improving patient outcomes and reducing costs with these expensive treatments A surface plasmon resonance (SPR)-based immunoassay has recently been shown to allow highly reliable and robust monitoring of serum concentrations of infliximab, with significant advantages over classical ELISA The next level of advancement would be the availability of compact and transportable SPR devices suitable for easy, fast and cheap point-of-care analysis Here we report the data obtained with recently developed, cost-effective, optical-fibre-based SPR sensors (SPR-POF), which allow the construction of a compact miniaturized system for remote sensing We carried out an extensive characterization of infliximab binding to an anti-infliximab antibody immobilized on the SPR-POF sensor surface The present proof-of-principle studies demonstrate the feasibility of the proposed SPR-POF platform for the specific detection of infliximab, in both buffer and human serum, and pave the way for further technological improvements