A.J. Pakstis

TL;DR: A global pattern of haplotype variation and linkage disequilibrium suggests a common and recent African origin for all non-African human populations.

TL;DR: The results of a two-stage genome-wide search for genes conferring susceptibility to schizophrenia were reported in this article. But none of these genes have been found to be associated with the HLA region on chromosome 6p.

TL;DR: Allele frequencies for both systems show significant global variation, and consequently so do haplotype frequencies, which document a large potential for population stratification in association studies of either of these SLC6A4 polymorphisms.

TL;DR: The pattern of haplotype diversity and linkage disequilibrium observed supports a recent African-origin model of modern human evolution and suggests that the original mutation event that gave rise to DM-causing alleles arose in a population ancestral to non-Africans prior to migration of modern humans out of Africa.

TL;DR: This study lays the groundwork for the eventual identification of common TS susceptibility variants in larger cohorts and helps to provide a more complete understanding of the full genetic architecture of this disorder.