Lisa Osiecki

TL;DR: It is confirmed that psychiatric comorbidities are common among individuals with TS, demonstrates that most comor bidities begin early in life, and indicates that certain comorbiities may be mediated by the presence of comorbrid OCD or ADHD.

TL;DR: A meta-analysis from two independent OCD consortia, investigating a total of 2688 individuals of European ancestry with OCD and 7037 genomically matched controls, concludes that the largest single OCD genome-wide study to date represents a major integrative step in elucidating the genetic causes of OCD.

TL;DR: The results indicate that there is some genetic overlap between these two phenotypically-related neuropsychiatric disorders, but suggest that the two disorders have distinct genetic architectures.

TL;DR: Although no SNPs were identified to be associated with OCD at a genome-wide significant level in the combined trio–case–control sample, a significant enrichment of methylation QTLs and frontal lobe expression quantitative trait loci (eQTLs) was observed within the top-ranked SNPs, suggesting these top signals may have a broad role in gene expression in the brain, and possibly in the etiology of OCD.

TL;DR: Modulation of gene expression through noncoding variants, particularly within cortico-striatal circuits, is implicated as a fundamental mechanism in Tourette's syndrome pathogenesis, supporting the unification of Tourette’s syndrome and other tic disorders in future diagnostic schemata.